Triple-Networked Hybrid Hydrogels Reinforced with Montmorillonite Clay and Graphene Nanoplatelets for Soft and Hard Tissue Regeneration

Kumar, Anuj; Won, So-Yeon; Sood, Ankur; Choi, So‐Yeon; Singhmar, Ritu; Bhaskar, Rakesh; Kumar, Vineet; Zo, Sun Mi; Han, Seung-Soo

doi:10.3390/ijms232214158

Cited by 15 publications

(3 citation statements)

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“…The hybrid hydrogel network, which features a triple-network structure, exhibited enhanced mechanical properties as a result of dual-cross-linking and incorporation of nanofillers such as MMT and GNPs. 144 MMT in bioprinting offers enhanced mechanical properties and cellular activity when incorporated into bioink or hybrid hydrogels. However, limitations may arise in terms of optimization and potential interactions with other components, necessitating careful formulation and evaluation in bioprinting applications.…”

Section: Nanoclay-based Hybrid Bioinkmentioning

confidence: 99%

“…Kumar et al composed a hybrid hydrogel of poly(vinyl alcohol), polyacrylamide, sodium alginate, and MMT or MMT/graphene nanoplatelets (GNPs) through dynamic cross-linking, resulting in a porous structure, enhanced mechanical properties, and cellular activity. The hybrid hydrogel network, which features a triple-network structure, exhibited enhanced mechanical properties as a result of dual-cross-linking and incorporation of nanofillers such as MMT and GNPs …”

Section: Nanomaterials-based Hybrid Bioinksmentioning

confidence: 99%

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Nanomaterials-Based Hybrid Bioink Platforms in Advancing 3D Bioprinting Technologies for Regenerative Medicine

Chandra,

Reis,

Kundu

et al. 2024

ACS Biomater. Sci. Eng.

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3D bioprinting is recognized as the ultimate additive biomanufacturing technology in tissue engineering and regeneration, augmented with intelligent bioinks and bioprinters to construct tissues or organs, thereby eliminating the stipulation for artificial organs. For 3D bioprinting of soft tissues, such as kidneys, hearts, and other human body parts, formulations of bioink with enhanced bioinspired rheological and mechanical properties were essential. Nanomaterials-based hybrid bioinks have the potential to overcome the above-mentioned problem and require much attention among researchers. Natural and synthetic nanomaterials such as carbon nanotubes, graphene oxides, titanium oxides, nanosilicates, nanoclay, nanocellulose, etc. and their blended have been used in various 3D bioprinters as bioinks and benefitted enhanced bioprintability, biocompatibility, and biodegradability. A limited number of articles were published, and the above-mentioned requirement pushed us to write this review. We reviewed, explored, and discussed the nanomaterials and nanocomposite-based hybrid bioinks for the 3D bioprinting technology, 3D bioprinters properties, natural, synthetic, and nanomaterial-based hybrid bioinks, including applications with challenges, limitations, ethical considerations, potential solution for future perspective, and technological advancement of efficient and cost-effective 3D bioprinting methods in tissue regeneration and healthcare.

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Section: Nanoclay-based Hybrid Bioinkmentioning

confidence: 99%

Section: Nanomaterials-based Hybrid Bioinksmentioning

confidence: 99%

Nanomaterials-Based Hybrid Bioink Platforms in Advancing 3D Bioprinting Technologies for Regenerative Medicine

Chandra,

Reis,

Kundu

et al. 2024

ACS Biomater. Sci. Eng.

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“…Alginate is a naturally occurring biocompatible polysaccharide that is not found in mammals [ 19 ]. It is rich and inexpensive but has a low cell adhesion affinity.…”

Section: Three-dimensional Cell Culture Technologymentioning

confidence: 99%

Current Research Trends in the Application of In Vitro Three-Dimensional Models of Liver Cells

2022

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The liver produces and stores various nutrients that are necessary for the body and serves as a chemical plant, metabolizing carbohydrates, fats, hormones, vitamins, and minerals. It is also a vital organ for detoxifying drugs and exogenous harmful substances. Culturing liver cells in vitro under three-dimensional (3D) conditions is considered a primary mechanism for liver tissue engineering. The 3D cell culture system is designed to allow cells to interact in an artificially created environment and has the advantage of mimicking the physiological characteristics of cells in vivo. This system facilitates contact between the cells and the extracellular matrix. Several technically different approaches have been proposed, including bioreactors, chips, and plate-based systems in fluid or static media composed of chemically diverse materials. Compared to conventional two-dimensional monolayer culture in vitro models, the ability to predict the function of the tissues, including the drug metabolism and chemical toxicity, has been enhanced by developing three-dimensional liver culture models. This review discussed the methodology of 3D cell cultures and summarized the advantages of an in vitro liver platform using 3D culture technology.

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Strategy and Advancement in Hybrid Hydrogel and Their Applications: Recent Progress and Trends

Choudhary,

Sharma,

Singh

et al. 2024

Adv Eng Mater

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Advancements in polymers have made significant contribution in diverse application‐oriented fields. The multidisciplinary application of polymers generates a range of strategies, which is applicable in a wide range of biomedicines. Polymeric compounds such as hydrogels have been explored globally as a potent biomaterial that can furnish essential attributes due to their three‐dimensional (3D) soft and highly hydrophilic polymeric network. These hydrogels have been used extensively in various applications due to their biocompatible, biodegradable, and biosorption nature. However, they have some limitations, owing to their soft nature, low mechanical properties, and unsatisfactory degradation profile. Therefore, there is a need to develop novel, stronger, and more durable hybrid hydrogels with enhanced biocompatible and multifunctional properties. The current review gives a broad spectrum of hybrid hydrogels with its importance and significance. Further, the review highlights the strategies of generation of hybrid hydrogels reinforced with nanomaterials, biomaterials, and nanobiocomposites along with their advantages and disadvantages. The review also features various applications of these hybrid hydrogels in the field of biomedicines, photocatalysis, agriculture, and food industry over the last 5 years. This review will give a comprehensive overview to researchers working in the field of hybrid hydrogels development.

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Triple-Networked Hybrid Hydrogels Reinforced with Montmorillonite Clay and Graphene Nanoplatelets for Soft and Hard Tissue Regeneration

Cited by 15 publications

References 50 publications

Nanomaterials-Based Hybrid Bioink Platforms in Advancing 3D Bioprinting Technologies for Regenerative Medicine

Nanomaterials-Based Hybrid Bioink Platforms in Advancing 3D Bioprinting Technologies for Regenerative Medicine

Current Research Trends in the Application of In Vitro Three-Dimensional Models of Liver Cells

Strategy and Advancement in Hybrid Hydrogel and Their Applications: Recent Progress and Trends

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