Triple primary cancers involving kidney, urinary bladder, and liver in a dye worker

Morikawa, Yoshihiro; Shiomi, Kazu; Ishihara, Yasuhito; Matsuura, Nariaki

doi:10.1002/(sici)1097-0274(199701)31:1<44::aid-ajim7>3.0.co;2-x

Cited by 33 publications

(19 citation statements)

References 10 publications

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“…These include a common environmental (e.g. cigarette smoking and/or alcohol are linked to cancers of the urinary system, respiratory system, oral cavity, pharynx, esophagus, pancreas and cervix, and benzidene for RCC and bladder cancer) or genetic risk factor (co-occurrence of familial papillary carcinoma of thyroid and papillary carcinoma of the kidney linked to the chromosome locus 1q21) 25–27 . Familial RCC has also been shown to increase the risk of a second primary cancer in the urinary bladder and endocrine glands by nearly 3-fold 28 .…”

Section: Discussionmentioning

confidence: 99%

Incidence and Prognostic Significance of Second Primary Cancers in Renal Cell Carcinoma

Chakraborty

Tarantolo

Batra³

et al. 2013

American Journal of Clinical Oncology

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Background The survival of patients with renal cell carcinoma (RCC) has improved in recent years. However, data on the risk of developing a second cancer after a diagnosis of RCC is limited. We used the data available in the Surveillance Epidemiology and End Results (SEER) database to estimate the risk of second metachronous primary cancers in patients diagnosed with RCC between 1973 and 2006. Further, we also investigated the effect of the second primary cancers on the survival of RCC patients. Results 3,795 cases of second primary cancers (SPCs) were registered in SEER between 1973–2006. The ratio of observed/expected number of SPCs in RCC was 1.18 which was significantly greater than expected. Solid tumors comprised 90% of all second malignancies in RCC patients, with the most second cancers reported in the prostate gland and the digestive and respiratory systems. The overall risk of second primaries was highest in patients aged <30 years at the time of diagnosis. The site-specific risk of second cancers varied with the age at diagnosis, gender, race of the patient, size of the primary renal tumor and history of radiation therapy. Patients with second primaries had a significantly longer overall survival than those without second malignancies. An interval of <1 year between the diagnosis of RCC and the second primary was the strongest predictor of poor OS in RCC patients with a second malignancy. Conclusion Patients with RCC are at a significantly higher risk of developing a second malignancy suggesting the need for careful surveillance for their early detection and management.

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Section: Discussionmentioning

confidence: 99%

Incidence and Prognostic Significance of Second Primary Cancers in Renal Cell Carcinoma

Chakraborty

Tarantolo

Batra³

et al. 2013

American Journal of Clinical Oncology

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“…Lima et al [67] detected benzidine, a known carcinogen in a textile effluent which contained disperse orange 37, disperse blue 373 and disperse violet 93 dyes. Mathur et al [68], tested a total of seven dyes (cremazoles blue S1, cremazoles brown GR, cremazoles orange 3R, direct bordeaux, direct royal blue, direct congo red and direct violet) using AMES tests and witnessed the presence of mutagenic agents. It was noted that direct violet was the only dye with a mutagenicity ratio less than 2:0.…”

Section: Finishingmentioning

confidence: 99%

“…They observed that the cremazoles dyes were so toxic to microorganisms. Morikawa et al [68], reported evidence of kidney, liver and urinary bladder cancers on workers after prolonged exposure to textile dyes. It was found that dermatitis, asthma, nasal problems and rhinitis were acquired by workers after prolonged exposure to reactive dyes [69].…”

Section: Finishingmentioning

confidence: 99%

Production, Characterization and Treatment of Textile Effluents: A Critical Review

Ananthashankar¹

2013

Chem Eng Process Technol

264

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Textile industry is one of the major industries in the world that provide employment with no required special skills and play a major role in the economy of many countries. There are three different types of fibres used in the manufacture of various textile products: cellulose fibres, protein fibres and synthetic fibres. Each type of fibre is dyed with different types of dyes. Cellulose fibres are dyed using reactive dyes, direct dyes, napthol dyes and indigo dyes. Protein fibres are dyed using acid dyes and lanaset dyes. Synthetic fibres are dyed using disperse dyes, basic dyes and direct dyes. The textile industry utilizes various chemicals and large amount of water during the production process. About 200 L of water are used to produce 1 kg of textile. The water is mainly used for application of chemicals onto the fibres and rinsing of the final products. The waste water produced during this process contains large amount of dyes and chemicals containing trace metals such as Cr, As, Cu and Zn which are capable of harming the environment and human health. The textile waste water can cause haemorrhage, ulceration of skin, nausea, skin irritation and dermatitis. The chemicals present in the water block the sunlight and increase the biological oxygen demand thereby inhibiting photosynthesis and reoxygenation process. The effluent water discharged from the textile industries undergoes various physio-chemical processes such as flocculation, coagulation and ozonation followed by biological treatments for the removal of nitrogen, organics, phosphorous and metal. The whole treatment process involves three steps: primary treatment, secondary treatment and tertiary treatment. The primary treatment involves removal of suspended solids, most of the oil and grease and gritty materials. The secondary treatment is carried out using microorganisms under aerobic or anaerobic conditions and involves the reduction of BOD, phenol and remaining oil in the water and control of color. The tertiary treatment involves the use of electrodialysis, reverse osmosis and ion exchange to remove the final contaminants in the wastewater. The major disadvantages of using the biological process are that the presence of toxic metals in the effluent prevents efficient growth of microorganisms and the process requires a long retention time. The advanced oxidation processes is gaining attention in the recent days due to the ability to treat almost all the solid components in the textile effluents. The photo oxidation of the effluents is carried out using H 2 O 2 , combination of H 2 O 2 and UV and Combination of TiO 2 and UV. Advanced oxidation process generates low waste and uses hydroxyl radicals (OH • ) as their main oxidative power. The hydroxyl radicals (OH • ) are produced by chemical, electrical, mechanical or radiation energy and therefore advanced oxidation processes are classified under chemical, photochemical, catalytic, photocatalytic, mechanical and electrical processes. The effluents treated with advanced oxidation process were ...

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“…Benzidine is a known bladder carcinogen. However, a few reports have also implicated human exposure to benzidine and other arylamines in cancers of the pancreas [47], kidneys and liver [48]. In rats, mice, and hamsters, benzidine causes hepatocarcinogenicity [49].…”

Section: Importance Of Lo-mediated Xenobiotic Metabolismmentioning

confidence: 99%

Lipoxygenase - a versatile biocatalyst for biotransformation of endobiotics and xenobiotics

Kulkarni¹

2001

CMLS, Cell. Mol. Life Sci.

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Lipoxygenase, a member of the arachidonate cascade enzymes, dioxygenates polyenoic fatty acids to finally yield products with profound and distinct biological activity. This review summarizes the available evidence for another role played by lipoxygenases in the metabolism of endobiotics and xenobiotics. Although other mechanisms exist, a direct hydrogen abstraction by the enzyme and the peroxyl radical-dependent chemical oxidation appear to be central to the co-oxidase activity of lipoxygenases. Besides polyunsaturated fatty acids, H2O2, fatty acid hydroperoxides, and synthetic organic hydroperoxides support the lipoxygenase-catalyzed xenobiotic oxidation. The major reactions documented thus far include oxidation, epoxidation, hydroxylation, sulfoxidation, desulfuration, dearylation, and N-dealkylation. It is noteworthy that lipoxygenases are also capable of glutathione conjugation of certain xenobiotics. The enzyme system appears to be inducible following exposure to chemicals. Lipoxygenases are inhibited by a large number of chemicals, some of which also serve as co-substrates. Available data suggest that lipoxygenases contribute to in vivo metabolism of xenobiotics in mammals.

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Triple primary cancers involving kidney, urinary bladder, and liver in a dye worker

Cited by 33 publications

References 10 publications

Incidence and Prognostic Significance of Second Primary Cancers in Renal Cell Carcinoma

Incidence and Prognostic Significance of Second Primary Cancers in Renal Cell Carcinoma

Production, Characterization and Treatment of Textile Effluents: A Critical Review

Lipoxygenase - a versatile biocatalyst for biotransformation of endobiotics and xenobiotics

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