Tripterygium wilfordii polyglycosidium ameliorates pouchitis induced by dextran sulfate sodium in rats

Gao, Sen-Yang; Wu, Xia; Zhang, Yingying; Li, Kaiyu; Litian, Wang; Liu, Gang

doi:10.1016/j.intimp.2016.12.008

Cited by 3 publications

(3 citation statements)

References 36 publications

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“…Previous studies confirmed that the imbalance between T regulatory cells and autoreactive T helper cells is the main pathogenic factor triggering the autoimmune response, 15 while TwHF can regulate the ratio of CD4 + and CD8 + T cells and regulate the immune balance between Th17 cells and Tregs 16,17 . Correspondingly, TwHF can inhibit the expression of various inflammatory factors, such as tumor necrosis factor (TNF‐α), intercellular adhesion molecule 1 (ICAM‐1), nuclear transcription factor B (NF‐κB), interleukin (IL)‐1β, ‐2, ‐4, ‐5, ‐6, ‐8, ‐10, ‐17, and IL‐23 18,19 . BP is associated with elevated inflammatory cytokines and chemokines 4 …”

Section: Discussionmentioning

confidence: 93%

“…16,17 Correspondingly, TwHF can inhibit the expression of various inflammatory factors, such as tumor necrosis factor (TNF-α), intercellular adhesion molecule 1 (ICAM-1), nuclear transcription factor B (NF-κB), interleukin (IL)-1β, -2, -4, -5, -6, -8, -10, -17, and IL-23. 18,19 BP is associated with elevated inflammatory cytokines and chemokines. 4…”

Section: Relapsementioning

confidence: 99%

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Treatment of bullous pemphigoid in Chinese patients withTripterygium wilfordiiHook F

Jin

et al. 2020

Dermatologic Therapy

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Tripterygium wilfordii Hook F (TwHF) is a traditional Chinese herb used in many medicinal applications, but the treatment of bullous pemphigoid (BP) with TwHF has never been reported. The aim of this study was to evaluate the efficacy and safety of TwHF in BP patients. A retrospective study was performed from January 2015 to September 2019 in the Department of Dermatology, Peking Union Medical College Hospital. A total of 10 patients with mild to moderate BP and treated with TwHF were enrolled in the study with 10 mild or moderate BP patients treated with systemic glucocorticoid randomly selected as controls. In the TwHF group, a major response was seen in seven patients, a minor response in one and no response was seen in two patients. In the glucocorticoid group, a major response was seen in nine patients and a minor response in one patient. Two patients experienced treatment failure. The time to disease control in the TwHF group (34 ± 11 days) was longer as compared to the glucocorticoid group (18 ± 8 days, P < .05). Ten patients relapsed during the follow‐up period. The adverse events in the TwHF group were lower than those in the glucocorticoid group (13 vs 19). Low‐dose TwHF may be effective and safe for treating mild and moderate BP.

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Section: Discussionmentioning

confidence: 93%

Section: Relapsementioning

confidence: 99%

Treatment of bullous pemphigoid in Chinese patients withTripterygium wilfordiiHook F

Jin

et al. 2020

Dermatologic Therapy

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“…Multiglycosides of Tripterygium wilfordii (GTW), also known as T. wilfordii polysaccharides, are fat-soluble active compounds extracted from the roots of plants that belong to the Celastraceae family [ 5 ]. GTW has been used to treat autoimmune diseases such as rheumatoid arthritis and glomerulonephritis; however, it has also been associated with reproductive system toxicity and epididymal sperm deformities, decreased sperm concentration and motility, and the formation of vacuoles in the sperm mitochondrial sheath [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of Moriamin Forte on Testicular and Epididymal Damage in Rats with Oligoasthenospermia

Zhou

Zhang²,

Liang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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To investigate the effect and mechanism of action of Moriamin Forte (MF) on oligoasthenospermia (OA) in rats exposed to multiglycosides of Tripterygium wilfordii (GTW), forty male Sprague Dawley rats were randomly divided into four groups. Rats in the control group were treated with 0.5% sodium carboxymethyl cellulose. The remaining rats were administered GTW (30 mg/kg/d) for 40 d to establish an OA model. Concurrently, the groups were treated with normal saline and low-dose (100 mg/kg/d) and high-dose (200 mg/kg/d) MF, respectively. After treatment, the number and motility of sperm cells were examined. Testicular and epididymal histomorphology changes were observed. Antioxidant indicators (SOD, CAT, MDA, TAC, and Nrf2) in testicular and epididymal tissues were detected. Apoptotic and antiapoptotic indicators (Bax and Bcl2 expression) in the testicular tissue were measured by immunohistochemistry. GTW decreased sperm count and motility, damaged testicular and epididymis tissues, impaired antioxidase activity, and increased tissue MDA levels. Meanwhile, GTW upregulated the expression of Bax and downregulated the expression of Bcl2. Western blot analysis demonstrated a decrease in the Nrf2 expression in the model group. Treatment with MF improved sperm count and motility, as well as inhibited the rate of apoptosis in the rat reproductive system. Moreover, MF improved the activity of antioxidants and increased the relative expression of the antioxidant pathway-related protein Nrf2. In conclusion, MF may reverse the GTW-induced OA by modulating the expression of apoptotic and antioxidant pathway-related proteins. This study may provide a pharmacological foundation for the use of MF in OA treatment.

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ROS-responsive nanomicelles encapsulating celastrol ameliorate pressure overload-induced cardiac hypertrophy by regulating the NF-κB signaling pathway

Chen,

Yang,

Liu

2024

Journal of Biomaterials Science, Polymer Edition

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Tripterygium wilfordii polyglycosidium ameliorates pouchitis induced by dextran sulfate sodium in rats

Cited by 3 publications

References 36 publications

Treatment of bullous pemphigoid in Chinese patients withTripterygium wilfordiiHook F

Treatment of bullous pemphigoid in Chinese patients withTripterygium wilfordiiHook F

Impact of Moriamin Forte on Testicular and Epididymal Damage in Rats with Oligoasthenospermia

ROS-responsive nanomicelles encapsulating celastrol ameliorate pressure overload-induced cardiac hypertrophy by regulating the NF-κB signaling pathway

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