Triptolide attenuates inhibition of ankylosing spondylitis-derived mesenchymal stem cells on the osteoclastogenesis through modulating exosomal transfer of circ-0110634

Ji, Wei; Lu, Yueyang; Ma, Zhuoyi; Gan, Ke; Liu, Yan; Cheng, Ya; Xu, Jiang; Liu, Shijia; Guo, Yunke; Han, Shanhang; Zhao, Zengyan; Xu, Huimin; Qi, Weiyan

doi:10.1016/j.jot.2022.05.007

Cited by 10 publications

(11 citation statements)

References 42 publications

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“…Recent research showed that triptolide treatment stimulated osteoclastogenesis to alleviate arthritis in DBA/1 mice through the suppression of circ‐0110634. This study suggested that triptolide targeted circ‐0110634 to regulate osteoclastogenesis, providing a novel potential target in triptolide treatment for patients with ankylosing spondylitis (AS) 75 . Future research should seek to clarify how circRNAs influence osteoclastogenesis in order to better guide the treatment of OP and related disorders.…”

Section: The Regulation Of Osteoclastogenesis By Circrnasmentioning

confidence: 98%

“…This study suggested that triptolide targeted circ-0110634 to regulate 67 osteoclastogenesis, providing a novel potential target in triptolide treatment for patients with ankylosing spondylitis (AS). 75 Future research should seek to clarify how circRNAs influence osteoclastogenesis in order to better guide the treatment of OP and related disorders. For further details regarding how circRNAs shape the process of osteoclastogenic differentiation, see Table 3.…”

Section: The Regulation Of Osteoclastogenesis By Circrnasmentioning

confidence: 99%

“…Tao Wang and Xingnuan Li initiated the idea, the scope, and the outline of this review article. Chao Zhang and 75 Lin Xu studied and analyzed all of the publications cited in this article and were involved in the manuscript preparation. Tao Wang and Xingnuan Li conducted the final editing and proofreading.…”

Section: Author Contributionsmentioning

confidence: 99%

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Roles of circular RNAs in osteogenic/osteoclastogenic differentiation

Wang

Zhang

et al. 2023

BioFactors

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The process of bone remodeling occurs and is regulated through interactions between osteoclasts, which resorb bone, and osteoblasts, which generate bone tissue. When the homeostatic balance between these two cell types is dysregulated, this can contribute to abnormal bone remodeling resulting in a loss of bone mass as is observed in osteoporosis (OP) and other forms of degenerative bone metabolic diseases. At present, details of molecular mechanism underlying the development of bone metabolic diseases such as OP remain to be elucidated. Circular RNAs (circRNAs) are small non‐coding RNA molecules with a closed‐loop structure that can regulate the differentiation of osteoclasts and osteoblasts. The present review provides a systematic overview of recent literature on the processes through which circRNAs regulate the dynamic balance between osteoblasts and osteoclasts that ultimately preserve bone homeostasis. It will also give insight that can shape current understanding of the pathogenesis of OP and other bone metabolic diseases to better guide diagnostic and treatment strategies for affected patients.

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Section: The Regulation Of Osteoclastogenesis By Circrnasmentioning

confidence: 98%

Section: The Regulation Of Osteoclastogenesis By Circrnasmentioning

confidence: 99%

See 1 more Smart Citation

Roles of circular RNAs in osteogenic/osteoclastogenic differentiation

Wang

Zhang

et al. 2023

BioFactors

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“…Another research revealed that Circ-0110634 was expressed at a greater level in AxSpA patients’ MSC-derived exosomes than in healthy exosomes. Circ-0110634 is a circular RNA that inhibits osteoclastogenesis when overexpressed 166 .…”

Section: Msc-derived Evs: a Novel Cell-free Therapymentioning

confidence: 99%

Biology and therapeutic potential of mesenchymal stem cell extracellular vesicles in axial spondyloarthritis

Tavasolian

Inman

2023

Commun Biol

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Axial spondyloarthritis (AxSpA) is a chronic, inflammatory, autoimmune disease that predominantly affects the joints of the spine, causes chronic pain, and, in advanced stages, may result in spinal fusion. Recent developments in understanding the immunomodulatory and tissue-differentiating properties of mesenchymal stem cell (MSC) therapy have raised the possibility of applying such treatment to AxSpA. The therapeutic effectiveness of MSCs has been shown in numerous studies spanning a range of diseases. Several studies have been conducted examining acellular therapy based on MSC secretome. Extracellular vesicles (EVs) generated by MSCs have been proven to reproduce the impact of MSCs on target cells. These EVs are associated with immunological regulation, tissue remodeling, and cellular homeostasis. EVs’ biological effects rely on their cargo, with microRNAs (miRNAs) integrated into EVs playing a particularly important role in gene expression regulation. In this article, we will discuss the impact of MSCs and EVs generated by MSCs on target cells and how these may be used as unique treatment strategies for AxSpA.

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“…Triptolide is an epoxy diterpene lactone compound extracted from the roots, leaves, flowers and fruits of Tripterygium wilfordii Hook. f. Triptolide has a broad range of pharmacological effects on autoimmune diseases, including rheumatoid arthritis ( Li et al, 2022a ), systemic lupus erythematosus ( Zhang et al, 2022a ), ankylosing spondylitis ( Ji et al, 2022 ), and so on. Due to poor water solubility (0.017 mg/ml) and severe toxicity including excessive immune responses, its clinical application is greatly limited ( Ding et al, 2017 ), and several strategies has been applied to reduce its toxicity and to improve its solubility ( Kang et al, 2022a ; Zhang et al, 2022b ; Rao et al, 2022 ).…”

Section: Natural Products Undergoing Clinical Evaluation In Pancreati...mentioning

confidence: 99%

The therapeutic potential of natural products for treating pancreatic cancer

Wang

Zhang

et al. 2022

Front. Pharmacol.

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Pancreatic cancer is one of the most malignant tumors of the digestive tract, with the poor prognosis and low 5-year survival rate less than 10%. Although surgical resection and chemotherapy as gemcitabine (first-line treatment) has been applied to the pancreatic cancer patients, the overall survival rates of pancreatic cancer are quite low due to drug resistance. Therefore, it is of urgent need to develop alternative strategies for its treatment. In this review, we summarized the major herbal drugs and metabolites, including curcumin, triptolide, Panax Notoginseng Saponins and their metabolites etc. These compounds with antioxidant, anti-angiogenic and anti-metastatic activities can inhibit the progression and metastasis of pancreatic cancer. Expecting to provide comprehensive information of potential natural products, our review provides valuable information and strategies for pancreatic cancer treatment.

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Triptolide attenuates inhibition of ankylosing spondylitis-derived mesenchymal stem cells on the osteoclastogenesis through modulating exosomal transfer of circ-0110634

Cited by 10 publications

References 42 publications

Roles of circular RNAs in osteogenic/osteoclastogenic differentiation

Roles of circular RNAs in osteogenic/osteoclastogenic differentiation

Biology and therapeutic potential of mesenchymal stem cell extracellular vesicles in axial spondyloarthritis

The therapeutic potential of natural products for treating pancreatic cancer

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