Tris(2,2′-bipyridyl)ruthenium(III)-based electrochemiluminescence detector with indium/tin oxide working electrode for capillary electrophoresis

Chiang, Mei-Tsu; Whang, Chen‐Wen

doi:10.1016/s0021-9673(01)01279-1

Cited by 78 publications

(59 citation statements)

References 26 publications

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“…When the buffer concentration was changed from 10 to tion limits under the optimized conditions are listed in Table 1. The limit of detection for proline was about 2 µmol/L, this value being about two-fold higher than that reported by Chiang and Whang (16), and about 10-fold higher than that reported in Wang and Bobbit's work (15). Since the optimization was made according to the conditions in the biological matrix, the detection limit was still acceptable.…”

Section: Factors Influencing Ce Separationmentioning

confidence: 57%

A rapid capillary electrophoresis with electrochemiluminescence method for the assay of human urinary proline and hydroxyproline

Liang¹,

Xue²,

Tian³

et al. 2005

Luminescence

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A novel simultaneous determination method for free and total proline (Pro) and hydroxyproline (Hyp) in human urine was developed, based on capillary electrophoresis (CE) with electrochemiluminescence (ECL) detection, using tris-(2,2'-bipyridyl) ruthenium(II). Experimental conditions, such as the Ru(bpy)(3)2+ concentration, detection potentials, buffer concentration and pH in CE or in the ECL cell, injection voltage and time were investigated in detail. Under optimized conditions, the linear range, detection limit and sample recoveries for the method were 0.01-2 mmol/L (correlation coefficient, 0.9970), 4 micromol/L and 96.4-101.2% in human urine, respectively. The results show that the method has potential applications in monitoring the level of Pro and Hyp in body fluids from patients with bone disease, tumours or chronic uraemia.

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Section: Factors Influencing Ce Separationmentioning

confidence: 57%

A rapid capillary electrophoresis with electrochemiluminescence method for the assay of human urinary proline and hydroxyproline

Liang¹,

Xue²,

Tian³

et al. 2005

Luminescence

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show abstract

“…It has been found that, in general, electrochemical reaction of many organic molecules such as dopamine [15], ascorbic acid [16], tripropal amine [17] and oxalic acid [18] on ITO is significantly slower than metal and carbon electrodes. This has been attributed to the lack of catalytic sites on ITO, although the exact mechanism is still not clear.…”

Section: Resultsmentioning

confidence: 99%

“…Electrochemical reaction of many organic molecules such as dopamine [15], ascorbic acid [16], tripropal amine [17] and oxalic acid [18] on ITO is significantly slower than metal and carbon electrodes, likely due to the lack of catalytic sites on ITO. Specifically, ascorbic acid exhibits an apparent electrooxidation response at 0.5 V on metal electrodes [19,20] and at 0.6 V on glassy carbon electrode [21], whereas the oxidation reaction is inhibited and thereby results in a large overpotential on ITO [16].…”

Section: Introductionmentioning

confidence: 99%

High catalytic activity of indium tin oxide nanoparticle modified electrode towards electro-oxidation of ascorbic acid

Wei

Huang

Guo

2012

Journal of Electroanalytical Chemistry

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a b s t r a c tMetal nanoparticles and carbon nanotubes have been shown to possess high electrocatalytic activity. Indium tin oxide (ITO) is a popular electrode material, but the electro-catalytic properties of its nanomaterials have not been reported. We demonstrate here for the first time facile electrocatalytic oxidation of ascorbic acid on ITO nanoparticle-modified electrodes. Compared to the conventional ITO thin film electrode, the voltammetric peak potential for ascorbic acid oxidation was lowered by 800 mV on ITO nanoparticle-modified electrodes to a potential similar to metal electrodes. The ITO nanoparticle was composed of 90% In 2 O 3 and 10% SnO 2 . Since the electrocatalytic activity was also found on In 2 O 3 nanoparticle electrodes but not on SnO 2 nanoparticle electrodes, the In 2 O 3 composition in ITO nanoparticle is mainly responsible for the high activity. In photoluminescence measurement, two intense emission peaks at 415 nm and 438 nm associated with surface oxygen vacancies were observed on the semiconductor electrodes. It was hypothesized that the oxygen vacancies could be the active sites for electrocatalytic reactions. A linear relationship between the oxidation current and ascorbic acid concentration was found in the range of 10 lM to 5 mM, with a lower detection limit of 5 lM and 7.9% RSD (n = 11). The high electro-catalytic activity and transmittance of In 2 O 3 and ITO nanoparticle electrodes make them potentially very useful in opto-electronic devices and chemical/bio-sensors.

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“…According to the reports on the CL detection in capillary electrophoresis [14,15,21,26,27], there were two key points that decided whether the experiment could be done successfully. One was the reaction dynamics of the CL systems.…”

Section: Analytical Performancementioning

confidence: 99%

Capillary electrophoresis microchip coupled with on-line chemiluminescence detection

Lin

et al. 2004

Analytica Chimica Acta

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Tris(2,2′-bipyridyl)ruthenium(III)-based electrochemiluminescence detector with indium/tin oxide working electrode for capillary electrophoresis

Cited by 78 publications

References 26 publications

A rapid capillary electrophoresis with electrochemiluminescence method for the assay of human urinary proline and hydroxyproline

A rapid capillary electrophoresis with electrochemiluminescence method for the assay of human urinary proline and hydroxyproline

High catalytic activity of indium tin oxide nanoparticle modified electrode towards electro-oxidation of ascorbic acid

Capillary electrophoresis microchip coupled with on-line chemiluminescence detection

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