Tris-ACE-α-cyclodextrin tripods: chemistry and metal coordination behaviour

Abstract

The synthesis of C3-symmetrical tris-(ACE)-(6,6'-bis-heterocyclyl)-α-cyclodextrins via"one pot" Staudinger-Aza-Wittig (SAW) reaction is described. The spectroscopic properties of their metal coordination compounds were analysed. The spontaneous formation of metallosupramolecular helicates generate strong exciton coupling features enlighten much information on the nature, the geometries of the complexes and their absolute configuration.

Multifunctional 8‐Hydroxyquinoline‐Appended Cyclodextrins as New Inhibitors of Metal‐Induced Protein Aggregation

“…The CyD functionalization can improve their metal binding ability, leading to a wide range of applications. [34][35][36][37][38][39][40] Several CyD derivatives are widely used to remove cholesterol from food and cultured cells [41] and, in 2010, the Food and Drug Administration (FDA) approved the intrathecal and intravenous administration of hydroxypropyl b-cyclodextrin in twin girls suffering from Niemann-Pick Type C (NPC). Known as "childhood Alzheimer's", NPC is a rare, deadly neurodegenerative disease, characterized by elevated levels of unesterified cholesterol in lysosomal storage organelles, [42] oxidative stress, [43] and dyshomeostasis of metal ions.…”