Trisomy 21 and Coronavirus Disease 2019 in Pediatric Patients

Newman, Alexander; Jhaveri, Ravi; Patel, Ami B; Tan, Tina Q.; Toia, Jacqueline M.; Arshad, Mehreen

doi:10.1016/j.jpeds.2020.08.067

Cited by 24 publications

(28 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…No specific data on COVID-19 prevalence in pediatric patients with DS is currently available. Nevertheless, several case studies were recently described in such patients (Alsahabi et al 2021 ; Kantar et al 2020 ; Newman et al 2021 ; Pontes et al 2020 ). Out of the total of 10 cases presented in these publications, 3 (33%) were admitted to the ICU, 2 (20%) required intubation and none had died.…”

Section: Specific Predisposition To Severe Covid-19 In Dsmentioning

confidence: 99%

Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Illouz

Biragyn²,

Frenkel‐Morgenstern

et al. 2021

Neuromol Med

View full text Add to dashboard Cite

The current SARS-CoV-2 outbreak, which causes COVID-19, is particularly devastating for individuals with chronic medical conditions, in particular those with Down Syndrome (DS) who often exhibit a higher prevalence of respiratory tract infections, immune dysregulation and potential complications. The incidence of Alzheimer’s disease (AD) is much higher in DS than in the general population, possibly increasing further the risk of COVID-19 infection and its complications. Here we provide a biological overview with regard to specific susceptibility of individuals with DS to SARS-CoV-2 infection as well as data from a recent survey on the prevalence of COVID-19 among them. We see an urgent need to protect people with DS, especially those with AD, from COVID-19 and future pandemics and focus on developing protective measures, which also include interventions by health systems worldwide for reducing the negative social effects of long-term isolation and increased periods of hospitalization.

show abstract

Section: Specific Predisposition To Severe Covid-19 In Dsmentioning

confidence: 99%

Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Illouz

Biragyn²,

Frenkel‐Morgenstern

et al. 2021

Neuromol Med

View full text Add to dashboard Cite

show abstract

“…In a recent report by Newmann et al [9], the clinical courses of four children with DS and COVID-19 were reported: (1) a 17-year-old male with severe pneumonia, hypotension, and a hyperinflammatory state during hospitalisation; (2) a 10-month-old male with pneumonia, requiring support with high flow oxygen by nasal cannula; (3) a 15-year-old male presenting with oxygen desaturation (86%) requiring only supplementation via nasal cannula; and (4) a 14-year-old male with pneumonia of the lower lobes [9].…”

Section: Discussionmentioning

confidence: 94%

Multiple Organ Failure Associated with SARS-CoV-2 Infection in a Child with Down Syndrome: Is Trisomy 21 Associated with an Unfavourable Clinical Course?

Vazquez-Hernández

Cárdenas‐Conejo

Catalán-Ruiz

et al. 2021

Case Reports in Pediatrics

View full text Add to dashboard Cite

Introduction. Down syndrome (DS) is one of the most frequent genomic disorders around the globe (∼1:700 births). During the COVID-19 pandemic, it has been recognized that children with DS are patients with a greater risk of presenting SARS-CoV-2 infection-related poor outcomes. Nonetheless, a few cases with DS and SARS-CoV-2 infection have been reported. Our aim is to describe the unfavorable clinical course of a child with DS infected with SARS-CoV-2 virus. Case. Female, 2 years old, karyotype 47,XX,+21[30], previously diagnosed with a cyanotic congenital heart disease (tricuspid atresia and infundibular pulmonary stenosis, type Ib) who started with diarrhea, developed shortness of breath, and cyanosis and was admitted to the hospital presenting low-oxygen saturation (33%) requiring invasive mechanical ventilation support. The patient tested positive for SARS-CoV-2 infection. During hospitalization, the patient presented hypotension, anuria, retarded capillary filling, and metabolic acidosis; management with vasoactive drugs was needed. Nonetheless, the patient developed respiratory and cardiac failure, acute renal injury (AKIN-III), and septic shock. After 24 days of hospitalization, the patient died. Conclusions. Multiple organ failure observed in the patient presented could be related to the triple gene dose of four interferon receptors (IFNAR1, IFNAR2, IFNGR2, and IL10RB) located at 21q22.11. Additionally, overexpression of TMPRSS2 at the pulmonary level, located also at 21q22.3, could be related with an increased susceptibility for the development of SARS-CoV-2 infection in DS patients.

show abstract

“…Nine studies 21, 24, 27, 29, 31, 33, 36, 39, 42 included children with brain-based disabilities, and the remaining 20 included children at risk of developing a brain-based disability (premature infants and infants with congenital heart diseases in most studies) (Table 2). Most studies were published in the United States and the majority of studies were case reports or case series (23/29, 79%).…”

Section: Resultsmentioning

confidence: 99%

COVID-19 in Children with Brain-Based Developmental Disabilities: A Rapid Review Update

Dugas

Stefan

Lépine

et al. 2021

Preprint

View full text Add to dashboard Cite

Objective: Information regarding the impact of COVID-19 in children with brain-based disabilities, or those at risk of developing such conditions, remains scarce. The objective was to evaluate if children with brain-based disabilities are more likely to (1) develop COVID-19, (2) develop complications from the disease, and (3) to have a poorer prognosis. Study design: We conducted a rapid review using search strategies iteratively developed and tested by an experienced medical information specialist in consultation with the review team and a panel of knowledge users. Searches were initially performed on April 18th, 2021, and updated on October 31st, 2020. Four reviewers individually performed study selection using pilot-tested standardized forms. Single reviewers extracted the data using a standardized extraction form that included study characteristics, patients' characteristics, and outcomes reported. Results: We identified 1448 publications, of which 29 were included. Studies reported data on 2288 COVID-19 positive children, including 462 with a brain-based disability, and 72 at risk of developing such disability. Overall, the included studies showed a greater risk to develop severe COVID-19 disease in children with brain-based disabilities. Although mortality is very low, the case-fatality rate appeared to be higher in children with disabilities compared to children without disabilities. Conclusions: Our review shows that children with brain-based disabilities are overrepresented in hospitalization numbers compared to children without disabilities. However, most studies included children that were hospitalized from COVID-19 in secondary and tertiary care centers. Results of this review should therefore be interpreted with caution.

show abstract

Trisomy 21 and Coronavirus Disease 2019 in Pediatric Patients

Cited by 24 publications

References 18 publications

Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Specific Susceptibility to COVID-19 in Adults with Down Syndrome

Multiple Organ Failure Associated with SARS-CoV-2 Infection in a Child with Down Syndrome: Is Trisomy 21 Associated with an Unfavourable Clinical Course?

COVID-19 in Children with Brain-Based Developmental Disabilities: A Rapid Review Update

Contact Info

Product

Resources

About