Trisomy of chromosome 18 in the baboon <i>(Papio hamadryas anubis)</i>

Abstract

Trisomy 18 is usually a lethal chromosomal abnormality and is the second most common autosomal trisomy in humans, with an incidence of 1:8000 live births. It is commonly associated with abnormalities of the lower and upper extremities, having the frequency of 95% and 65%, respectively. A newborn female olive baboon (Papio hamadryas anubis) was diagnosed with intrauterine growth retardation and severe arthrogryposis-like congenital joint deformities. Cytogenetic analysis including G-banding and fluorescence in situ hybridization (FISH) revealed that the congenital abnormalities were associated with chromosomal mosaicism for trisomy 18. Genetic analysis with microsatellites from chromosome 18 confirmed the maternal origin of the extra chromosome 18. This is the first report of trisomy 18 in the baboon, which may be a promising animal model of human disease.

Chromosomal instability in rhesus macaque preimplantation embryos

“…Most assessed chromosomes in human preimplantation embryos are those commonly implicated in abnormal spontaneous abortions (chromosomes 13,16,18,21,22, X and Y) and chromosomally abnormal newborns (chromosomes 13, 18, 21, X and Y). Therefore, a comparable assay was developed for cytogenetic analysis of rhesus macaque preimplantation embryos.…”

“…Human preimplantation embryos display a wide range of aneuploidies (36,42), however a smaller range is frequently observed in spontaneous abortions (frequently chromosomes 13,15,16,18,21,22, X and Y) or in newborns (commonly chromosomes 13, 18, 21, X and Y). This indicates that while all chromosomes are susceptible to segregation errors to a certain extent, only certain errors, like those generally assessed during PGD, are favorable to result in a clinical pregnancy.…”

Mortality in captive baboons (Papio spp.): a‐23‐year study

“…The most often recovered bacteria were Streptococcus spp. (17,29.8%), Staphylococcus spp. (16, 28.1%), Escherichia coli (11,19.3%), Pasteurella multocida (6, 10.5%), and Klebsiella pneumoniae (5, 8.8%); bacteria were identified histologically in seven baboons where lung culture was not performed.…”

Trisomy 17 in a baboon (Papio hamadryas) with polydactyly, patent foramen ovale and pyelectasis

“…Infant necropsies (less than 2 days of age) during this period averaged 91 per year. One other autosomal abnormality (trisomy 18 in a baboon) has been identified in this time period [Howell et al, 2006]. Ruppenthal et al [2004] reported a case of trisomy 16 in a macaque and provided details of 11 previously reported cases of autosomal trisomy in nonhuman primates.…”