Triterpene glycosides from red ginseng marc and their anti-inflammatory activities

Influence of Accelerated Solvent Extraction Conditions on the LC-ESI-MS/MS Polyphenolic Profile, Triterpenoid Content, and Antioxidant and Anti-lipoxygenase Activity of Rhododendron luteum Sweet Leaves

“…Since antioxidant and anti-inflammatory activity are attributed to the presence of polyphenols (including flavonoids) [ 1 , 4 , 29 ] and triterpenes [ 7 , 8 , 9 , 10 ], total phenolic (TPC), total flavonoid (TFC), and total triterpene content (TTC) were determined in all the examined extracts.…”

“…Similarly, plant pentacyclic triterpenes possess strong anti-inflammatory activity. The mechanism of their action is based on their capacity of blocking nuclear factor-κB (NFκB), reducing NO production, and inhibiting the release of pro-inflammatory cytokines, such as IL-6, IL-8, IL-1β, and TNFα [ 7 , 8 , 9 , 10 ]. Moreover, triterpene acids isolated from frankincense were found to have anti-inflammatory activity based on the suppression of prostaglandin E2 synthase (mPGES-1) [ 11 ].…”

Flavonoid-enriched fraction from Echinodorus macrophyllus aqueous extract exhibits high in-vitro and in-vivo anti-inflammatory activity

“…Nitric oxide, a simple gas molecule, is synthesized from l ‐arginine and oxygen by nitric oxide synthase (NOS) in different cells, including endothelial and neuronal cells, and phagocytes (eNOS, nNOS and iNOS, respectively) . As NO mediates vasodilatation and vascular permeability, stimulates leucocyte migration and AEEm and its fractions altered these parameters, their effects on in‐vitro NO production were also evaluated.…”

“…Nitric oxide, a simple gas molecule, is synthesized from L-arginine and oxygen by nitric oxide synthase (NOS) in different cells, including endothelial and neuronal cells, and phagocytes (eNOS, nNOS and iNOS, respectively). [42] As NO mediates vasodilatation and vascular permeability, stimulates leucocyte migration [43][44][45] and AEEm and its fractions altered these parameters, their effects on in-vitro NO production were also evaluated. LPS stimulated the NO production (17.86 lM), according to the literature, [46] and AEEm inhibited NO production just on 0.1 lg/ml, corroborating inhibition data by another macrophage cell line (J774).…”

O-Glicosídeos 2,3-Insaturados: Aplicações, Rearranjo De Ferrier E Reações

“…Em 2014, Chung e colaboradores 41 isolaram três glicosídeos triterpênicos (Figura 5), o ursano-3β,19α,22β-triol-3-O-β-D-glicopiranosil (2′→1″)-β-D-glicopiranosideo, ursano-3α,11-β-diol-3-O-α-D-glucopiranosil-(6′→1″)-α-D-glicopiranosil-(6″→1′″)-α-D-glicopiranosyl -(6′″→1″″)-α-D-glicopiranosideo e lanosto-5,24-dien-3β-ol-3-O--β-D-glicopiranosil-(6′→1″)-β-D-glicopiranosil-(6″→1′″)-β-D-glicopiranosideo, da erva Ginseng vermelho, que exibiram atividades anti-inflamatórias contra células da linhagem RAW 264,7 de macrófagos murínicos. As estruturas dos triterpenos foram elucidadas por técnicas espectróscópicas, tais como infravermelho, RMN 1 H e 13 C, COSY, HMBC e MS.…”