Triterpenoid and Fatty Acid Contents from the Stem Bark of Cordia dichotoma (Forst f.)

Nariya, Pankajkumar B.; Shukla, VJ; Acharya, Rabinarayan; Nariya, Mukeshkumar; Dhalani, J. M.; Patel, Anilkumar S.; Ambasana, Pratik

doi:10.2478/folmed-2018-0026

Cited by 9 publications

(3 citation statements)

References 7 publications

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“…1. Cholest-5-En-3ol (3beta)carbonyl chlorinated [9] Camphesterol [9] Leaves and Flowers evidence and statistical data. It was also discovered to regulate blood urea levels.…”

Section: Transverse Section Of Leafmentioning

confidence: 99%

Phytopharmacology and Applications of Cordia Macleodii: A Miraculous Plant

2023

IJBPAS

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The use of plants and plant products as medicinal plants based on their therapeutic potential is well recognized and has been used for the treatment of various diseases and ailments since ancient times. Cordia macleodii, commonly known as Dahiman or Dahipalas or Shikari, a plant belonging to the family Boraginaceae, is one of the rare medicinal plants reported to possess potential therapeutic activities such as anti-inflammatory, antimicrobial, analgesic, hepatoprotective, wound healing, antihypertensive and antioxidant. The presence of various bioactive compounds like terpenoids, flavanoids, glycosides, phenols, tannins, saponins, steroids, volatile oils, amino acids, alkaloids, and resins make C.macleodii a valuable potent herbal medicinal plant. Though the plant has potential health benefits and medicinal value, there is only limited literature available about the plant, so there is a need for an extensive survey and exploration of knowledge about C.macleodii. The present review summarizes geographical sources, phytochemical constituents, potential biological activity and application, ethnobotanical and medicinal uses, and toxicity. The review finally concluded with a discussion of future prospects.

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“…1. Cholest-5-En-3ol (3beta)carbonyl chlorinated [9] Camphesterol [9] Leaves and Flowers evidence and statistical data. It was also discovered to regulate blood urea levels.…”

Section: Transverse Section Of Leafmentioning

confidence: 99%

Phytopharmacology and Applications of Cordia Macleodii: A Miraculous Plant

2023

IJBPAS

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“…Many classical methods and references are readily available for the extraction and identification of steroids and terpenoids from other medicinal plants [19][20][21][22][23] ; yet it is necessary to determine a specific method to isolate these molecules or fractions which ought to be standardized. [24][25][26][27]…”

Section: Aimmentioning

confidence: 99%

Steroid and fatty acid contents from the leaves of Carica papaya

Devmurari

Patel

Jadeja

et al. 2021

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Aim: To extract and identify the non-polar entities from the leaves of Carica papaya, a plant used for medicinal purpose as folk medicine.Materials and methods: Petroleum ether extract of the Carica papaya leaves was used for this study. Saponification process and methylation process was performed to separate fatty acids and unsaponifiable matters. Phytochemical constituents were separated using chemical process and separated fractions were analyzed by thin layer chromatography (TLC) and gas chromatography coupled with mass spectroscopy (GC-MS).Results: The chemical composition of the steroids, triterpenoids and fatty acid methyl esters (FAMEs) in leaves of Carica papaya, which were analyzed by gas chromatography coupled with mass spectroscopy (GC-MS). A total of 15 fatty acid components were identified in saponifiable matter, from unsaponifiable portion 2 steroids (campesterol, β- or γ-sitosterol), 1 triterpene (squalene), and 1 diterpene (phytol) were identified.Conclusions: The results indicate that the extract is rich in non-polar compounds. In this study, GC-MS method is at the central focus for identification of these phytoconstituents. The current method can be used for direct analysis of non-polar entities of plant material.

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“…Previous phytochemical investigations of plants from this genus reported the isolation and characterization of different classes of secondary metabolites including naphthoquinones, hydroquinones [8], cromenes [9], terpenenoids [10] or polyphenols [11]. Meanwhile and based on some pharmacological surveys, essential oils from C. curassivica and C. gilletii appeared as active against some microbial strains [12,13] Some biological activities and in silico investigations of C. dichotoma were recently reported [14,15]; the plant is also known to contain, apart from allantoin (1) [16,17] which has been the subject of many quantum calculations [18,19], fatty acids (FA) [20]. FA appear as energy sources for M. tuberculosis inside host tissues and are supposed to induce dormancy in Mycobacterium bacilli [21,22].…”

Section: Introductionmentioning

confidence: 99%

Density Functional Theory of a New Derivative of Allantoin with Antiplasmodial Properties, Antimycobacterial Activities of Essential Oil from Cordia Batesii WERNHAM (Boraginaceae)

Tiam

Bikobo

Ndassa

et al. 2020

Preprint

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Background: some chemical and pharmacological investigations were performed on the EtOAc and/or CH2Cl2 extracts of the stems of Cordia batesii (Boraginaeae); one of its components was subjected to some quantum calculations to get improvement in the understanding of its 13C–NMR and UV properties along with geometric, electronic, thermodynamic data and reactivity descriptors. Results: a new allantoin (1) derivative named batesiin (2) was characterized from the EtOAc extract; thirteen known compounds including allantoin (1) were either isolated or identified by means of MS, NMR, LC–MS and GC–MS. GC–MS was applied on a fraction of essential oil which was composed of a mixture of fatty acids (9–14). Density functional theory (DFT) calculations were applied on batesiin (2). Data were simulated using B3LYP and MPW1PW91 functionals; calculated chemical shifts at B3LYP/6–31G(d,p) and MPW1PW91/6–31G+(d,p) showed much better correlations with the experimental data. Time dependent DFT applied on 2 at B3LYP/6–31G+(d,p) displayed a major absorption band at λmax = 299.01 nm using chloroform as solvent, 3.01 nm higher than the experimental value. In addition, The MeOH extract of the stems and some isolated compounds were tested in vitro against Pf7G8 CQS and Pf Dd2 CQR strains of Plasmodium falciparum; meanwhile, the CH2Cl2 extract and the mixture of fatty acids (9–14) were tested on a resistant mycobacterial strain of Mycobacterium tuberculosis codified AC45. Stems disclosed a moderate antiplasmodial activity (IC50 = 50 μg/mL) and the mixture 9–14 a potent antimycobacterial activity with a MIC = 9.52 μg/mL.Conclusion: these results tend to emphasize on the use of DFT studies when trying to learn more about the chemical structure through spectroscopic data of a natural compound, especially the case of a derivative of allantoin (1); essential oil from Cordia batesii presents interesting antimycobacterial activities which need to gain more visibility; further antiplasmodial tests should rely on batesiin (2) and other components of the species.

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Triterpenoid and Fatty Acid Contents from the Stem Bark of Cordia dichotoma (Forst f.)

Cited by 9 publications

References 7 publications

Phytopharmacology and Applications of Cordia Macleodii: A Miraculous Plant

Phytopharmacology and Applications of Cordia Macleodii: A Miraculous Plant

Steroid and fatty acid contents from the leaves of Carica papaya

Density Functional Theory of a New Derivative of Allantoin with Antiplasmodial Properties, Antimycobacterial Activities of Essential Oil from Cordia Batesii WERNHAM (Boraginaceae)

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