Triterpenoid saponins from Anemone rivularis var. flore-minore

Ding, Yu; Tang, Hai‐Feng; Wang, Jianbo; Liú, Dan; Tian, Xiangrong; Wang, Xiaoyang; Zhou, Xiaoming

doi:10.1016/j.bse.2011.04.001

Cited by 14 publications

(5 citation statements)

References 13 publications

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“…The structures of the new compounds ( 1 – 3 ) were elucidated on the basis of extensive NMR spectroscopic analysis, including a series of 2D-NMR experiments ( Figure 2 ) (HSQC, HMBC), and mass spectrometry data. The known compounds ( 4 – 10 ) were identified by comparison of their experimental spectral data with literature data [ 4 , 5 , 6 , 7 , 8 , 9 , 10 ].…”

Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Triterpenoids from the Caulophyllum robustum Maximin LPS-Stimulated RAW264.7 Cells

et al. 2018

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Caulophyllum robustum Maxim is widely distributed in China and used as a traditional herbal medicine to induce childbirth, ease the pain of labor, rectify delayed or irregular menstruation, alleviate heavy bleeding and pain during menstruation, and treat external injuries and irregular menses. According to our detailed chemical investigation, three new triterpene derivatives (1–3), together with seven known compounds, were isolated from the root and rhizome of C. robustum Maxim. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analysis and physio-chemical methods. They were identified as (1) 23-hydroxy-3,19-dioxo-olean-12-en-28-oic-acid; (2) 23-hydroxy-3,11-dioxo-olean-12-en-28-oic acid; and (3) 16α,23-dihydroxy-3-oxo-olean-12-en-28-oic acid. Compounds (1–10) inhibited the LPS-activated NO production in RAW264.7 cells. Furthermore, the anti-inflammatory characteristics of these compounds were confirmed on the basis of decreases in iNOS and NF-κB protein expression in RAW264.7 cells.

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Section: Resultsmentioning

confidence: 99%

Anti-Inflammatory Triterpenoids from the Caulophyllum robustum Maximin LPS-Stimulated RAW264.7 Cells

et al. 2018

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“…By comparing their physical and spectroscopic data with those reported in the literature, the known compounds were identified as sapindoside B ( 6 ) [25], pulsatilla saponin D ( 7 ) [26], 3- O -β- d -xylopyranosyl-(1→3)-α- l -rhamnopyranosyl-(1→2)-[β- d -glucopyranosyl-(1→4)]-α- l -arabinopyranosyl oleanolic acid ( 8 ) [27], sieboldianoside B ( 9 ) [28], and 3- O -α- l -arabinopyranosyl gypsogenin 28- O -α- l -rhamnopyranosyl-(1→4)-β- d -glucopyranosyl-(1→6)-β- d -glucopyranosyl ester ( 10 ) [11], respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Our previous phytochemical investigations of the whole plants of this species resulted in the isolation of a new gypsogenin saponin, a new diterpene glycoside, a new lignanoid glycoside, as well as a series of oleanane-type triterpenoid saponins [11,12]. As part of our ongoing search for new bioactive natural compounds from this genus [11,12,13,14,15,16], the present study of the rhizomes of A. rivularis var. flore-minore led to the isolation of five new oleanane-type saponins 1 − 5 , along with five known saponins 6 − 10 (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Oleanane-Type Triterpenoid Saponins from the Rhizomes of Anemone rivularis var. flore-minore

Wang

Wang²,

Xu³

et al. 2014

Molecules

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Phytochemical investigation of the n-BuOH extract of the rhizomes of Anemone rivularis var. flore-minore led to the isolation of five new oleanane-type triterpenoid saponins 1-5, together with five known saponins 6-10. Their structures were determined by the extensive use of 1D and 2D NMR experiments, along with ESIMS analyses and acid hydrolysis. The aglycone of 4 and 5 was determined as 21α-hydroxyoleanolic acid, which was reported in this genus for the first time. The cytotoxicity of these compounds was evaluated against four human cancer cell line, including HL-60 (promyelocytic leukemia), HepG2 (hepatocellular carcinoma), A549 (lung carcinoma) and HeLa (cervical carcinoma). The monodesmosidic saponins 6-8 exhibited cytotoxic activity toward all tested cancer cell lines, with IC 50 values in the 7.25-22.38 μM range.

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“…[9]. As part of our continuing study to explore bioactive natural products from the genus Anemone [10,11,12,13,14,15,16,17], we continued the investigation of this plant. In our present study, five new triterpenoid saponins ( 1 – 5 ), together with eight known ones ( 6 – 1 3 ) (Figure 1) were isolated, among which lupane-type saponins ( 3 and 12 ) were first reported from the Anemone genus.…”

Section: Introductionmentioning

confidence: 99%