Triterpenoid saponins from Polycarpaea corymbosa Lamk. var. eriantha Hochst

Manase, Mahenina Jaovita; Mitaine-Offer, Anne Claire; Miyamoto, Tomofumi; Tanaka, Chiaki; Delemasure, Stéphanie; Dutartre, Patrick; Lacaille‐Dubois, Marie‐Aleth

doi:10.1016/j.phytochem.2013.12.005

Cited by 15 publications

(9 citation statements)

References 18 publications

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“…Murine mammary carcinoma cell line EMT-6 and human colorectal adenocarcinoma cell line SW480, purchased from American Type Culture Collection (ATCC, Manassas, VA), were cultured in DMEM supplemented with 10% of fetal bovine serum and penicillin (100 U/mL), streptomycin (100 mg/mL), amphotericin B (250 ng/mL) and placed in CO 2 incubator with 5% of CO 2 at 37 C. Cells were seeded in a 96-well microplate at 3.125 Â 10 4 cells/mL and treated with compounds (10, 30 and 100 mM) for 48 h. Doxorubicin, etoposide, 5-fluorouracil and methotrexate (10 mM) were used as anti-cancer references. The anti-proliferative activity of compounds and drug references were determined using XTT assay 30,31 . This assay is based on the conversion of the water-soluble XTT (sodium 2,3,-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)-carbonyl]-2H-tetrazolium) inner salt) reagent, in the presence of the electron-coupling reagent PMS (phenazine methylsulfate) to an orange formazan product by metabolically active cells.…”

Section: Determination Of Anti-proliferative Activity In Emt-6 and Swmentioning

confidence: 99%

Microwave-assisted synthesis, anti-inflammatory and anti-proliferative activities of new maslinic acid derivatives bearing 1,5- and 1,4-disubstituted triazoles

Chouaïb

Delemasure²,

Dutartre³

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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In this work, 40 analogs with a natural maslinic acid core (from Olea europaea L.) and various aromatic azides were synthesized. A regiospecific, facile and practical synthesis of 1,5-triazolyl derivatives by Ru(II)-catalyzed azide-alkyne cycloaddition (RuAAC), and mono-, bis- and tri-1,4-triazolyl derivatives by Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) was described. All the reactions were assisted by microwave irradiation avoiding toxic reagents and solvents. The new products were obtained from the reaction mixture by simple purification in almost quantitative yields and the reaction times were in general shorter than those reported in the literature. Their chemical structures were elucidated on the basis of extensive spectroscopic methods including ESI-HRMS, 1D and 2D-NMR. Most of the compounds were evaluated for their anti-inflammatory activity using LPS-stimulated human peripheral blood mononuclear cells (PBMCs) and antiproliferative effects towards cultured murine EMT-6 (Breast) and human SW480 (colon) cancer cell lines.

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Section: Determination Of Anti-proliferative Activity In Emt-6 and Swmentioning

confidence: 99%

Microwave-assisted synthesis, anti-inflammatory and anti-proliferative activities of new maslinic acid derivatives bearing 1,5- and 1,4-disubstituted triazoles

Chouaïb

Delemasure²,

Dutartre³

et al. 2016

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…All three new compounds were tested for their toxicity against brine shrimp, and the results indicated that all exhibited moderate activity, with LD 50 values of 0.9, 2.2, and 2.1 µM, respectively. 8) Bioassay-guided fractionation of the ethyl acetate (EtOAc) fraction of the stem bark of Muntafara sessilifolia (Apocynaceae) led to the isolation of four vobasinyl-iboga bisindoles (25)(26)(27)(28) and one 2-acyl monomeric indole (29) alkaloid, along with eight known alkaloids (3-oxocoronaridin hydroxyindolenine, eglandulosine, eglandine, coronaridine, tabernaemontanine, and tabernaelegantines A, B, and D). All the isolated compounds were evaluated for their ability to inhibit the in vitro intraerythrocytic development of the chloroquine-resistant strain FcB1 of P. falciparum.…”

Section: Alkaloidsmentioning

confidence: 99%

“…The reduced activity of compound 69 compared with 68 is possibly due to the bulkiness of the 4-coumaroyl group that acylated the C-16 hydroxyl group. 27) Four triterpene saponins (70-73), along with the known apoanagallosaponin IV, were isolated from Polycarpaea corymbosa LAMK. var.…”

Section: Alkaloidsmentioning

confidence: 99%

Novel Bioactive Natural Products Isolated from Madagascar Plants and Marine Organisms (2009–2017)

Dai

Liu

Rakotondraibe

2018

CHEMICAL & PHARMACEUTICAL BULLETIN

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Madagascar's rain forests and tropical dry forests are home to numerous endemic plant species and the island is considered a biodiversity hotspot. About 80% of the Madagascan (Malagasy) population relies on traditional medicines that have been proven to contain a variety of biologically active compounds. In the search for bioactive compounds from Madagascan biodiversity, we accessed and collected most of the literature dealing with the isolation, structure elucidation, and biological activities of organic small molecules originating from Madagascan plants and marine organisms. Since we published the first review of this work in 2009 (Curr. Med. Chem., 17, 2010, Hou and Harinantenaina), the present paper covers the isolation, structures, and bioactivity of 182 new secondary metabolites isolated from Malagasy higher plants and marine organisms in the last seven years (2009-2017).

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“…6 In literature the plant is recorded to possess hepatoprotective, cytotoxic, antioxidant and antiradical activities. [7][8][9] Also, it has been documented to contain camelliagenin A, A1-barrigenol, stigmastanol, apoanagallosaponin IV, n-hexadecanoic acid and 5-hydroxymethyl furfural along with some phenols and flavanoids. [9][10][11] Lupeol, a triterpenoid, is reported to be having multiple biological actions noticeably anti-inflammatory, hepatoprotective, antiprotozoal, antimicrobial, chemoproptective etc.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9] Also, it has been documented to contain camelliagenin A, A1-barrigenol, stigmastanol, apoanagallosaponin IV, n-hexadecanoic acid and 5-hydroxymethyl furfural along with some phenols and flavanoids. [9][10][11] Lupeol, a triterpenoid, is reported to be having multiple biological actions noticeably anti-inflammatory, hepatoprotective, antiprotozoal, antimicrobial, chemoproptective etc. [12][13][14] In the present study, we here propose data for development of a comprehensive monograph, a requisite for quality assessment.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Investigation and Pharmacognostic Standardization of Polycarpaea corymbosa Lam

Modi¹,

Shah²

2017

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Background:Polycarpaea corymbosa is one of the plants cited as 'Parpata' in Ayurvedic literature and indicated for boils, inflammatory swellings, and ulcers. Aim: The present study is an attempt to generate and encompass the data of physical parameters for ascertaining the identification and develop a validated HPTLC method for quantification of lupeol in P. corymbosa. Materials and Methods: The whole plant was studied for establishing pharmacognostic standards including macro and microscopical characters, physico-chemical analysis and quantification lupeol by HPTLC method. Results: It is a small, much branched, erect or spreading herb with linear leaf and silvery-white cymes. Microscopically root can be connoted by continuous or discontinuous concentric rings of xylem and phloem; stem by papillose epidermis with multicellular branched collapsed and glandular trichomes, sclerenchymatous pericycle and hollow pith; and leaf by numerous collateral meristele enclosed within parenchymatous bundle sheath. Further studies evinced that brunt of heavy metal and microbial load in plant material was within permissible limits. Flavonoids, phenolics and saponins were found be major components. HPTLC method was developed for quantification of lupeol using precoated silica gel plates as a stationary phase, and toluene: methanol (9.4: 0.6) as a mobile phase and scanning the plate at 545 nm. Conclusion: The information demonstrated on pharmacognostic parameters and validated HPTLC method for estimation of lupeol for Polycarpaea corymbosa, would aid as coherent measures for its assessment.

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Triterpenoid saponins from Polycarpaea corymbosa Lamk. var. eriantha Hochst

Cited by 15 publications

References 18 publications

Microwave-assisted synthesis, anti-inflammatory and anti-proliferative activities of new maslinic acid derivatives bearing 1,5- and 1,4-disubstituted triazoles

Microwave-assisted synthesis, anti-inflammatory and anti-proliferative activities of new maslinic acid derivatives bearing 1,5- and 1,4-disubstituted triazoles

Novel Bioactive Natural Products Isolated from Madagascar Plants and Marine Organisms (2009–2017)

Phytochemical Investigation and Pharmacognostic Standardization of Polycarpaea corymbosa Lam

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