Triterpenoids and meroterpenoids with α-glucosidase inhibitory activities from the fruiting bodies of Ganoderma australe

Lanostane Triterpenoids and Ergostane Steroids from Ganoderma luteomarginatum and Their Cytotoxicity

“…The thirty-one known compounds, including twenty-one lanostane triterpenoids (4-26) and eight ergostane steroid (27)(28)(29)(30)(31)(32)(33)(34), were identified as lanosta-8,24E-dien-7-oxo -3β-acetyloxy-26-ol (4) [26], lanosta-8,24E-dien-7-oxo-3β-acetyloxy-26-al (5) [26], lanosta -7,9(11),24-trien-3β-acetyloxy-26-ol (6) [26], (24R,25S)-lanosta-7,9(11)-dien-3β,24,26-triol -25-methoxy (7) [16], lanosta-7,9(11)-dien-3β-acetyloxy-24,25,26-triol (8) [29], lanosta-7,9(11) -dien-3β-acetyloxy-24,26-dihydroxy-25-methoxy (9) [29], ganodermanondiol (10) [34], lu-cidumol B (11) [34], 26-hydroxy-ganodermanondiol (12) [35], ganoderiol A (13) [36], ganoderone A (14) [37], lucidadiol (15) [38], ganodermadiol (16) [39], lanosta-7,9(11),24E -trien-3β-acetyloxy-26,27-diol (17) [29], ganoderiol F (18) [40], lanosta-8-en-7,11-dioxo-3β -acetyloxy-24,25,26-triol (19) [29], ganoderiol D (20) [40], lanosta-8-en-7-oxo-3β -acetyloxy-24,25,26-trihydroxy (21) [34], lucidumol A (22) [41], lanosta-7,9 (11),24E-trien -3-oxo-26-al (23) [42], lanosta-7,9(11),24-triene-3β-ol-26-al (24) [42], lucidone H (25) [29], lucidadone H (26) [...…”

“…Recent research on chemical constituents of Ganoderma species showed that lanostane-type triterpenoids are the main characteristic natural products [ 4 ], and more than 400 lanostanoids have been isolated from the fungi of Ganoderma . These small molecule compounds have attracted considerable attention due to their extensive biological and pharmacological activities [ 5 , 6 ], including cytotoxic [ 7 , 8 , 9 ], hepatoprotective [ 10 , 11 ], anti-inflammatory [ 12 , 13 , 14 ], antidiabetic [ 15 , 16 ], neuroprotective [ 17 ], antiviral [ 18 ], antiaging [ 19 ], and antioxidant [ 20 , 21 , 22 ] effects. The genus Ganoderma is used as a healthy food and has been traditionally used for the prevention of numerous diseases or various pathological conditions, including complementary cancer therapy, especially a broad-spectrum application for the treatment of cancer.…”

Tetra-, penta-, and hexa-nor-lanostane triterpenes from the medicinal fungus Ganoderma australe

“…This fungus, however, was chemically under-investigated compared to other easily widely used Ganoderma species, such as G. lucidum , G. cochlear , and G. sinense . Previous studies on the secondary metabolites of G. australe have led to the isolation of some lanostane triterpenes [ 10 – 13 ], meroterpenoids [ 14 , 15 ], and alkaloids [ 14 ]. In this study, we would like to report ten new nor-lanostane triterpenes isolated from G. australe , of which the structures are assigned by extensive NMR and HRESIMS spectroscopic analysis.…”

[20(22)E]-Lanostane Triterpenes from the Fungus Ganoderma australe

“…However, this fungus has rarely been chemically investigated compared to other Ganoderma species, such as G. lucidum , G. cochlear , and G. sinense . Previous studies on this fungus have led to the isolation of lanostane triterpenes [ 18 , 19 , 20 , 21 ], meroterpenoids [ 22 , 23 ], and alkaloids [ 22 ]. The lanostanoids from this species are over-oxygenated compared to the ones isolated from other species of Ganoderma , especially the position of C-20 [ 18 , 20 ].…”

“…Previous studies on this fungus have led to the isolation of lanostane triterpenes [ 18 , 19 , 20 , 21 ], meroterpenoids [ 22 , 23 ], and alkaloids [ 22 ]. The lanostanoids from this species are over-oxygenated compared to the ones isolated from other species of Ganoderma , especially the position of C-20 [ 18 , 20 ]. The quaternary hydroxy group substituted at C-20 led to the introduction of an additional chiral carbon of which the stereochemistry was difficult to be assigned even by chemical derivatization.…”