Triterpenoids and Sesquiterpenes from<i>Mulgedium tataricum</i>

Wang, Xiaoxiong; Lin, Changjun; Jia, Zhong‐Jian

doi:10.1055/s-2006-941508

Cited by 14 publications

(9 citation statements)

References 5 publications

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“…169 A cytotoxic sesquiterpene lactone, lactucin-8-O-p-methoxyphenyl acetate 303, has been obtained from Mulgedium tataricum. 170 The structure of 1α,8α-epidioxy-4α-hydroxy-5αH-guai-7(11),9-dien-12,8-olide 304, isolated from Curcuma wenyujin with anti-influenza viral activity, has been confirmed by single-crystal X-ray diffraction experiment. 171 The complete relative configuration of the known sesquiterpene (+)-dioxo-sarcoguaiacol has been established.…”

mentioning

confidence: 88%

“…194 A germacranolide peroxide 342 was identified as a component of mulgedium tataricum. 170 Chemical investigation of Santolina insularis afforded two germacrane sesquiterpene peroxides 343 and 344, which might derive from the formal photo-oxygenation of the corresponding ∆ 4,5 olefin, a reaction well precedented in medium-sized olefins. …”

Section: Bisabolanes and Germacranesmentioning

confidence: 99%

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Peroxy natural products

Liu

2013

Nat. Prod. Bioprospect.

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confidence: 88%

Section: Bisabolanes and Germacranesmentioning

confidence: 99%

Peroxy natural products

Liu

2013

Nat. Prod. Bioprospect.

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“…UA is a natural pentacyclic triterpene isolated from several medicinal plants such as Baccharis uncinella, Rosemarinus officinalis, and Radix actinidiae ; it has anti-inflammatory [ 19 ], anti-cancer [ 20 ], and anti-microbial activities [ 20 , 21 , 22 , 23 , 24 , 25 ]. In L. (L.) amazonensis, UA induced morphological, physiological, and biochemical alterations that resembled programmed cell death; additionally, BALB/c mice treated with UA by the intralesional route improved cutaneous lesions and showed lower tissue parasites than non-treated infected mice [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Ursolic Acid Potentializes Conventional Therapy in Experimental Leishmaniasis

et al. 2020

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Ursolic acid (UA) is a triterpene with a broad array of pharmacological activities. In leishmaniasis, UA killed different species of parasites, and it was active in the experimental model of cutaneous and visceral leishmaniasis. Thus, the objective of this work was to study the therapeutic efficacy of the conventional drugs amphotericin B (AmB) or glucantime (Glu) combined with UA in experimental visceral and cutaneous leishmaniasis, respectively. L. (L.) infantum-infected hamsters were treated with AmB alone or combined with UA. L. (L.) amazonensis-infected BALB/c mice were treated with Glu alone or combined with UA. Animals were treated for 15 consecutive days by intraperitoneal or intralesional routes. Following one week after the last dose, the tissue parasitism and cellular immune responses were analyzed. Hamsters treated with 0.2 and 1.0 mg/kg of AmB plus 1.0 mg/kg of UA showed low hepatic and splenic parasitisms; however, AmB given as monotherapy did not reduce the number of viable parasites in the spleen of treated animals. In cutaneous leishmaniasis, Glu given as monotherapy was inactive at 2.0 mg/kg, showed mild activity at 10.0 mg/kg, and at 50.0 mg/kg was highly active at eliminating parasites in the skin. When animals were treated with Glu plus UA, higher leishmanicidal activity was observed in comparison to all groups treated with monotherapy schemes, and such activity was related to lesion improvement and upregulation of IFN-γ production. Altogether, data suggest that the association of drugs for the treatment of leishmaniasis can increase the efficiency of the treatment and decrease the toxicity associated to the conventional drugs.

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“…Compound 5 was identified as a lanost-9(11),25-diene-3β,24β-diol and compound 6 was identified to be a lanost-9(11),23E(24)-diene-3β,25-diol by comparison of literature NMR data and mass spectra reported for compounds isolated from Mulgedium tataricum (L.) DC. (Asteraceae) [10,11]. Compound 7 was identified as (+) syringaresinol by comparing its NMR data with those available in the literature [12].…”

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confidence: 99%

Leucas mollissima, a Source of Bioactive Compounds with Antimalarial and Antimycobacterium Activities

et al. 2015

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!A phytochemical investigation of the acetone extract from the aerial parts of Leucas mollissima afforded one new (−)epi-marmelo lactone, (2 S, 4R, 6 S)-2,6-dimethyl-6 hydroxy-7-ene-4-olide (1), along with five known compounds, schensianol A (2), vanillin (3), β-hydroxy propiovanillone (4), lanost-9(11),25-diene-3β,24β-diol (5), and lanost-9(11),23E(24)-diene-3β,25-diol (6). Similarly, an investigation of the methanol extract of the aerial parts of L. mollissima resulted in the isolation of three known compounds, (+)-syringaresinol (7), anisofolin A (8), and apigenin 7-O-β-D(− 6′′-p-E-coumaroyl)-glucoside (9). Structure elucidation of the isolated compounds was carried out using detailed analysis of 1D and 2D nuclear magnetic resonance. All compounds were evaluated for antimalarial activity against Plasmodium falciparum (3D7) and for antimycobacterium activity against Mycobacterium tuberculosis H37Ra and Mycobacterium bovis. Compound 8 was found to have promising antimalarial activity (IC 50 4.39 ± 0.25 µM), promising antimycobacterium activity [IC 50 4.50 ± 0.75 µM (3.31 µg/mL)] against M. tuberculosis H37Ra and at 100 µg/mL, showed 55.6 % inhibition of M. bovis. Compound 9 showed moderate inhibition of P. falciparum growth (35% inhibition at 10 µM) with respect to the positive control atovaquone and 67.4 % inhibition against M. bovis at 100 µg/mL with respect to the positive control rifampicin.

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Triterpenoids and Sesquiterpenes fromMulgedium tataricum

Cited by 14 publications

References 5 publications

Peroxy natural products

Peroxy natural products

Ursolic Acid Potentializes Conventional Therapy in Experimental Leishmaniasis

Leucas mollissima, a Source of Bioactive Compounds with Antimalarial and Antimycobacterium Activities

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