Triterpenoids from Inonotus obliquus and their antitumor activities

Antioxidant, α‐amylase and α‐glucosidase activity of various solvent fractions of I. obliquus and the preventive role of active fraction against H2O2 induced damage in hepatic L02 cells as fungisome

“…This species was highly enriched with many bioactive constituents such as polysaccharides, terpenoids, sterols, alkaloids, polyphenols, and flavonoids. Previous literatures revealed that almost 120 different classes of compounds have been isolated from this species (Zhao et al., 2015; Liu et al., 2014). Most of the isolated compounds were reported to exhibit significant antioxidant, antitumor, and anti‐inflammatory properties.…”

“…Most of the isolated compounds were reported to exhibit significant antioxidant, antitumor, and anti‐inflammatory properties. Many studies demonstrated their cytotoxicity against various cancer cell lines such as A549 (lung cancer), HT29 (human colorectal), Hela (cervical), L1210 (mouse leukemia), 4T1 (mouse breast), MCF‐7 (human breast), and B16‐F10 (mouse melanoma) cells (Ma, Chen, Dong, & Lu, 2013; Liu et al., 2014; Zhao et al., 2015). Glamočlija et al.…”

Antitumor and immunomodulatory activity of Inonotus obliquus

“…In mice inoculated subcutaneously with mouse sarcoma, Sarcoma 180 (S-180) cell lines, and administered orally in different doses (20,60 and 100 mg/kg) of an aqueous extract of I. obliquus sclerotium, lymphocyte viability, the weight of the organs of the immune system, thymus and spleen, the tumor mass as well as the expression of proteins produced by Bax and Bcl-2 genes in tumor cells and the release of tumor necrosis factor-α (TNF-α) from lymphocytes from the peritoneal cavity of mice were examined. At the same time, the impact of I. obliquus extract on the S-180 cells was examined in vitro.…”

“…Most research on the pharmacological activity of the fruiting bodies of this fungus has been carried out in the research centers in Germany, Japan, Korea and the Republic of China. Fruiting bodies of this fungus are rich sources of various biologically active compounds, such as polysaccharides [4][5][6][7][8][9][10][11][12][13], phenolic compounds [14][15][16], triterpenes [17][18][19][20], betulin and betulinic acid [21], ergosterol and ergosterol peroxide [22], inotodiol [23], and melanin [24]. Research have shown that extracts of Inonotus obliquus indicate the anti-inflammatory [25][26][27], immunomodulatory [5,[28][29][30], anticancer [10,19,20,[31][32][33][34][35][36][37][38][39], antiviral [40,41], anti-platelet [42], antiallergic [43] and antidiabetic activity [44,…”

Triterpenes with Anti-invasive Activity from Sclerotia of Inonotus obliquus

“…In the previous study, we reported the isolation and structure elucidation of several triterpenes from the sclerotia of I. obliquus collected in Japan [1]. Furthermore, several chemical and biological studies on I. obliquus have been reported [2][3][4][5][6]. For example, triterpenes were isolated as chemical constituents with cytotoxic effects from the sclerotia of I. obliquus [2][3][4][5].…”