Triterpenoids from the aerial parts of <i>Anabasis articulata</i> (Forssk) Moq: gastroprotective effect in vivo with in silico studies, cytotoxic and antimicrobial activities

Gamal, Ghada; Abo-El-Seoud, Kamilia A; Attia, Ghada

doi:10.1080/14786419.2021.1961769

Cited by 7 publications

(2 citation statements)

References 14 publications

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“…Treatment of rats with indomethacininduced ulcers with an ethyl acetate fraction (400 mg/kg, po/day) resulted in a decrease in the ulcerative index (0.18) and a strong inhibition of the percentage of ulcers (84.86%) compared with ranitidine. The compound showed a high rate of docking against the H+/K+-AT phase of the stomach [77].…”

Section: Gastroprotective Effectmentioning

confidence: 99%

Pharmacological Properties of Four Plant Species of the Genus Anabasis, Amaranthaceae

Shegebayev,

Turgumbayeva,

Datkhayev

et al. 2023

Molecules

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The genus Anabasis is a member of the family Amaranthaceae (former name: Chenopodiaceae) and includes approximately 102 genera and 1400 species. The genus Anabasis is one of the most significant families in salt marshes, semi-deserts, and other harsh environments. They are also renowned for their abundance in bioactive compounds, including sesquiterpenes, diterpenes, triterpenes, saponins, phenolic acids, flavonoids, and betalain pigments. Since ancient times, these plants have been used to treat various diseases of the gastrointestinal tract, diabetes, hypertension, and cardiovascular diseases and are used as an antirheumatic and diuretic. At the same time, the genus Anabasis is very rich in biologically active secondary metabolites that exhibit great pharmacological properties such as antioxidant, antibacterial, antiangiogenic, antiulcer, hypoglycemic, hepatoprotective, antidiabetic, etc. All of the listed pharmacological activities have been studied in practice by scientists from different countries and are presented in this review article to familiarize the entire scientific community with the results of these studies, as well as to explore the possibilities of using four plant species of the genus Anabasis as medicinal raw materials and developing medicines based on them.

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Section: Gastroprotective Effectmentioning

confidence: 99%

Pharmacological Properties of Four Plant Species of the Genus Anabasis, Amaranthaceae

Shegebayev,

Turgumbayeva,

Datkhayev

et al. 2023

Molecules

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“…Also, picraquassioside C, syringin, piceoside, tortoside A, and phytolaccagenicacid-3-O-β-D-glucopyranuronide 28-β-D-glucopyranosyl ester were isolated for the first time from the n-butanol extract of A. salsa [8]. Gamal et al isolated and identified seven triterpenoids from aerial parts of A. articulata, and chemical analysis by Abdou et al showed that the n-butenol extract of A. setifera contains a triterpene saponin (sophradiol [9,10]. Moreover, Shakeri et al and Mohammadi et al demonstrated that the two species, A. aphyll and A. setifera are a source of secondary metabolites; saponins, alkaloids, phenols, terpenes, and sterols [11,12].…”

Section: Introductionmentioning

confidence: 99%

Anabasis oropediorum Maire. as a health-promoting source: Phytochemical content, in vitro antioxidant, antidiabetic, antibacterial, and anti-inflammatory potential

GHERAISSA,

CHEMSA,

CHERRADA

et al. 2023

jrp

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Phytochemicals, which are necessary for plants to adapt to their environment, offer an exciting source of medicinal products. This study focuses on the desert plant Anabasis oropediorum (Chenopodiaceae), which is native to calcareous sandy regions in North African countries and Palestine. This investigation is the first to shed light on the therapeutic nature of the methanolic extract of the aerial parts of A. oropediorum. A phytochemical screening analysis was conducted, including a quantitative estimate of the total phenols, flavonoids, flavonols, anthocyanins, hydrolyzable tannins, and condensed tannins. Antioxidant activity was evaluated in vitro using three methods: DPPH • scavenging, β-carotene bleaching, and anti-hemolytic assay. The antidiabetic activity was tested using two assays: non-enzymatic hemoglobin glycosylation and glucose uptake by yeast cells assay. Antibacterial activity was evaluated by the disc diffusion method, and anti-inflammatory activity was evaluated by the protein anti-denaturation method. Phytochemical screening revealed the presence of alkaloids, coumarins, cardiac glycosides, leuco-anthocyanins, mucilage, phenols, saponins, sterols, and terpenes. The quantitative analysis showed that the methanolic extract provided a high level of flavonoids (17.0±0.50 µg QE/mg) and the total contents of tannins (5.3±0.04 µg GAE/mg, 7.3±0.14 µg CE/mg). Chlorogenic acid, p-coumaric acid, quercetin, and rutin were the phenolic compounds detected by RP-HPLC analysis. FTIR spectroscopy confirmed the presence of alkanes, aromatic compounds, and aliphatic amines in the methanolic extract. Biologically, this medicinal plant exhibited medium antioxidant activity, good in vitro antidiabetic activity, antibacterial activity against only Staphylococcus aureus, Listeria innocua, and Escherichia coli, and very good albumin protection activity from heat denaturation.

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Medicinal plants cultivated in Egypt with anticancer potential; a systematic review

Elshnoudy,

Elkhouly,

Masoud

et al. 2024

Phytochem Rev

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The increase in cases of various cancers, the number of cancer patients, and the serious side effects of current chemical treatments have encouraged researchers to discover novel and more effective drugs from plant sources. In this review, PubMed and Scopus were searched for English-language peer-reviewed articles published since 1994, using the keywords: Medicinal plants, Egypt, and Cancer. The inclusion criteria for this systematic review were English peer-reviewed original research articles. A total of 286 studies were included. Studies have shown that the active compounds in certain plants can have anticancer activities by various mechanisms, such as cell cycle arrest, apoptosis induction, and antioxidant effects. Additionally, it is evident that medicinal plants can act as inhibitors of cancer cells. Plants can also act as immune checkpoint inhibitors, which inhibit proteins such as PD-L1 on tumor cells, PD-1 and CTLA-4 on T cells, and help to regulate immune responses. This review also discusses the efficacy of nanoparticles of these plants against cancer cells. The findings indicate the high potential of investigating the bioactive anticancer components of Egyptian medicinal plants for advancing novel treatments that are more effective in combating cancer. The extracts and active compounds of the medicinal plants detailed in this review could provide the foundation for further clinical trials to be conducted, to develop new anticancer drugs.

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Triterpenoids from the aerial parts of Anabasis articulata (Forssk) Moq: gastroprotective effect in vivo with in silico studies, cytotoxic and antimicrobial activities

Cited by 7 publications

References 14 publications

Pharmacological Properties of Four Plant Species of the Genus Anabasis, Amaranthaceae

Pharmacological Properties of Four Plant Species of the Genus Anabasis, Amaranthaceae

Anabasis oropediorum Maire. as a health-promoting source: Phytochemical content, in vitro antioxidant, antidiabetic, antibacterial, and anti-inflammatory potential

Medicinal plants cultivated in Egypt with anticancer potential; a systematic review

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