Triton X-100/β-Cyclodextrin Cloud Point Extraction for Removal of Phenol Using Different of Sodium Salts as Inducing Phase Separation Agent

Asman, Saliza; Abas, Nur Azlie

doi:10.14233/ajchem.2018.21228

Cited by 4 publications

(1 citation statement)

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“…Because of the acidic environment in the stomach, the pH in the stomach is relatively low (typically around pH 1-3) [68]. At such low pH values, the acidic conditions can lead to the protonation of TX-100 surfactant molecules, which can disrupt the hydrophobic interactions within the micellar core [69]. The release of cefotaxime is facilitated by the micelle disintegration, making the drug available for absorption and therapeutic activity downstream from the gastrointestinal system.…”

Section: Study Of Release Mechanism Of Cefotaximementioning

confidence: 99%

Unveiling the Role of Nonionic Surfactants in Enhancing Cefotaxime Drug Solubility: A UV-Visible Spectroscopic Investigation in Single and Mixed Micellar Formulations

Rana,

Yusaf,

Shahid

et al. 2023

Pharmaceuticals

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This study reports the interfacial phenomenon of cefotaxime in combination with nonionic surfactants, Triton X-100 (TX-100) and Tween-80 (TW-80), and their mixed micellar formulations. Cefotaxime was enclosed in a micellar system to improve its solubility and effectiveness. TX-100 and TW-80 were used in an amphiphilic self-assembly process to create the micellar formulation. The effect of the addition of TX-100, a nonionic surfactant, on the ability of TW-80 to solubilize the drug was examined. The values of the critical micelle concentration (CMC) were determined via UV-Visible spectroscopy. Gibbs free energies (ΔGp and ΔGb), the partition coefficient (Kx), and the binding constant (Kb) were also computed. In a single micellar system, the partition coefficient (Kx) was found to be 33.78 × 106 and 2.78 × 106 in the presence of TX-100 and TW-80, respectively. In a mixed micellar system, the value of the partition coefficient for the CEF/TW-80 system is maximum (5.48 × 106) in the presence of 0.0019 mM of TX-100, which shows that TX-100 significantly enhances the solubilizing power of micelles. It has been demonstrated that these surfactants are effective in enhancing the solubility and bioavailability of therapeutic compounds. This study elaborates on the physicochemical characteristics and solubilization of reactive drugs in single and mixed micellar media. This investigation, conducted in the presence of surfactants, shows a large contribution to the binding process via both hydrogen bonding and hydrophobic interactions.

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Section: Study Of Release Mechanism Of Cefotaximementioning

confidence: 99%