Tritylamine (triphenylmethylamine) in organic synthesis; II. The reaction of tritylamine with oxiranes – synthesis of N-trityl-β-aminoalcohols

Abstract

The tritylamine (triphenylmethylamine) reacts regioselectively with oxiranes to give crystalline N-tritylated β-aminoalcohols -useful building blocks in organic synthesis, with reasonable yield. The N-trityl-β-aminoalcohols hydrolyze quantitatively to β-aminoalcohol hydrochlorides by means of hydrochloric acid.