Trizygotic quintuplet pregnancy following simultaneous embryo splitting in an oocyte donatin cycle

Abstract

Purpose To report a trizygotic quintuplet pregnancy following simultaneous embryo splitting in an oocyte donation cycle after transfer of 3 embryos. Methods A 40-year-old Caucasian female G3P1 with two previous spontaneous abortions and diminished ovarian reserve presented for IVF. The patient underwent an oocyte donation cycle secondary to diminished ovarian reserve. Three embryos were transferred per patient request. Results The three embryo transfer resulted in a trizygotic quintuplet pregnancy. Selective embryo reduction was performed at 11 weeks leaving a dizygotic twin gestation. The patient underwent SVD, or spontaneous vaginal delivery at 36 weeks gestation with respective weights and apgars of 2673 g (apgars 7(1), 9(5)) and 2722 g (apgars 7(1), 9(5)). The twins are presently doing well without complications. Conclusions Although rare, the possibility of simultaneous embryo splitting must be factored into determining number of embryos for fresh transfer.

Prenatal Diagnosis of a Spontaneous Monochorionic Five-Amniotic Quintuplet Pregnancy

“…Thereby, ovulation induction by clomiphene, gonadotropins [5][6][7][8][9][10] or the simultaneous transfer of several blastocysts after assisted reproductive techniques are the most important etiologic factors [11] . Quintuplet pregnancies have been described not only after the transfer of 5 but also after the transfer of only 2 or 3 zygotes or blastocysts which is explained by simultaneous embryo splitting [12][13][14][15] . Monochorionic (MC) pairs are relatively common in naturally conceived twins and in higher-order multiple gestations with more than 3 fetuses arising from assisted reproductive technology.…”