tRNALys-Derived Fragment Alleviates Cisplatin-Induced Apoptosis in Prostate Cancer Cells

Yang, Changwon; Lee, Minkyeong; Song, Gwonhwa; Lim, Whasun

doi:10.3390/pharmaceutics13010055

Cited by 34 publications

(30 citation statements)

References 49 publications

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“…Compared with our results, a considerable amount of studies were consistent with the present research concerning the function of tsRNAs. Recent studies discovered that tsRNAs are related to some kinds of tumors (21)(22)(23)(24). Mo et al uncovered that 5-tiRNA Val was able to act as an inhibitor in breast cancer (12).…”

Section: Discussionmentioning

confidence: 99%

tRNA-Derived Fragment tRF-Glu-TTC-027 Regulates the Progression of Gastric Carcinoma via MAPK Signaling Pathway

Zhou

Wang

et al. 2021

Front. Oncol.

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Transfer RNA-derived RNA fragments (tRFs) belong to non-coding RNAs (ncRNAs) discovered in most carcinomas. Although some articles have demonstrated the characteristics of tRFs in gastric carcinoma (GC), the underlying mechanisms still need to be elucidated. Meanwhile, it was reported that the MAPK pathway was momentous in GC progression. Thus we focused on investigating whether tRF-Glu-TTC-027 could act as a key role in the progression of GC with the regulation of the MAPK pathway. We collected the data of the tRNA-derived fragments expression profile from six paired clinical GC tissues and corresponding adjacent normal samples in this study. Then we screened tRF-Glu-TTC-027 for analysis by using RT-PCR. We transfected GC cell lines with tRF-Glu-TTC-027 mimics or mimics control. Then the proliferation, migration, and invasion assays were performed to assess the influence of tRF-Glu-TTC-027 on GC cell lines. Fluorescence in situ hybridization assay was conducted to confirm the cell distribution of tRF-Glu-TTC-027. We confirmed the mechanism that tRF-Glu-TTC-027 influenced the MAPK signaling pathway and observed a strong downregulation of tRF-Glu-TTC-027 in clinical GC samples. Overexpression of tRF-Glu-TTC-027 suppressed the malignant activities of GC in vitro and in vivo. MAPK signaling pathway was confirmed to be a target pathway of tRF-Glu-TTC-027 in GC by western blot. This is the first study to show that tRF-Glu-TTC-027 was a new tumor-suppressor and could be a potential object for molecular targeted therapy in GC.

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Section: Discussionmentioning

confidence: 99%

tRNA-Derived Fragment tRF-Glu-TTC-027 Regulates the Progression of Gastric Carcinoma via MAPK Signaling Pathway

Zhou

Wang

et al. 2021

Front. Oncol.

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“…Yang et al investigated the significance of tsRNA in cancer drug resistance. In prostate cancer (PCa) cells, cisplatin treatment induced ANG-dependent tRF-315 production [ 132 ]. tRF-315 suppressed cisplatin-mediated apoptosis and mitochondrial dysfunction [ 132 ].…”

Section: Roles In Diseasementioning

confidence: 99%

Deciphering the tRNA-derived small RNAs: origin, development, and future

et al. 2021

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Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the roles of tsRNAs in the development of human diseases. However, our knowledge about tsRNAs is still relatively lacking. In this paper, we review the biogenesis, classification, subcellular localization as well as action mechanism of tsRNAs, and discuss the association between chemical modifications of tRNAs and the production and functions of tsRNAs. Furthermore, using immunity, metabolism, and malignancy as examples, we summarize the molecular mechanisms of tsRNAs in diseases and evaluate the potential of tsRNAs as new biomarkers and therapeutic targets. At the same time, we compile and introduce several resource databases that are currently publicly available for analyzing tsRNAs. Finally, we discuss the challenges associated with research in this field and future directions.

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“…Another bioinformatic analysis showed that tDR-0009 (tDR-7336) might be involved in the chemoresistance and doxorubicin resistance of triple-negative breast cancer (TNBC) via regulation of STAT3 phosphorylation and the IL-6 response [ 78 ]. Moreover, tRF-315 derived from tRNA-Lys was demonstrated to be overexpressed in prostate cancer cells and relieved the cisplatin-induced apoptosis and mitochondrial dysfunction of these cancer cells by targeting the cell cycle-related gene GADD45A [ 79 ]. Therefore, research on the drug resistance functions of tRFs in cancer cells is in its early stages, and there will be more studies that reveal the mechanisms of tRF regulation of cancer drug resistance in the future.…”

Section: Tsrnas and Cancer Hallmarksmentioning

confidence: 99%

tRNA-derived small RNAs: novel regulators of cancer hallmarks and targets of clinical application

Liu

Zhao

et al. 2021

Cell Death Discov.

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AbstracttRNAs are a group of conventional noncoding RNAs (ncRNAs) with critical roles in the biological synthesis of proteins. Recently, tRNA-derived small RNAs (tsRNAs) were found to have important biological functions in the development of human diseases including carcinomas, rather than just being considered pure degradation material. tsRNAs not only are abnormally expressed in the cancer tissues and serum of cancer patients, but also have been suggested to regulate various vital cancer hallmarks. On the other hand, the application of tsRNAs as biomarkers and therapeutic targets is promising. In this review, we focused on the basic characteristics of tsRNAs, and their biological functions known thus far, and explored the regulatory roles of tsRNAs in cancer hallmarks including proliferation, apoptosis, metastasis, tumor microenvironment, drug resistance, cancer stem cell phenotype, and cancer cell metabolism. In addition, we also discussed the research progress on the application of tsRNAs as tumor biomarkers and therapeutic targets.

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tRNALys-Derived Fragment Alleviates Cisplatin-Induced Apoptosis in Prostate Cancer Cells

Cited by 34 publications

References 49 publications

tRNA-Derived Fragment tRF-Glu-TTC-027 Regulates the Progression of Gastric Carcinoma via MAPK Signaling Pathway

tRNA-Derived Fragment tRF-Glu-TTC-027 Regulates the Progression of Gastric Carcinoma via MAPK Signaling Pathway

Deciphering the tRNA-derived small RNAs: origin, development, and future

tRNA-derived small RNAs: novel regulators of cancer hallmarks and targets of clinical application

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