Troglitazone inhibits the migration and invasion of PC‑3 human prostate cancer cells by upregulating E‑cadherin and glutathione peroxidase 3

Chang, Seo Il; Lee, Ji Min; Oh, Hanseul; Kim, Ukjin; Ryu, Bokyeong; Park, Jae‐Hak

doi:10.3892/ol.2018.9278

Cited by 16 publications

(14 citation statements)

References 47 publications

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“…Glutathione peroxidase 3 (GPX3) belongs to GPX family, its main function as an antioxidant is to get rid of harmful free radicals (FR) and detoxify toxins from cells. It is implicated in cellular proliferation, division, and differentiation (Bansal and Simon, 2018 (Chang et al, 2018). Different studies suggested that GPX3 expression may have an impact on the pathogenesis of various tumors and that it serves as a tumor suppressor gene and its deficiency interferes with tumorogenesis.…”

Section: Discussionmentioning

confidence: 99%

Implications of Glutathione Peroxidase 3 Expression in a Cohort of Egyptian Patients with Acute Myeloid Leukemia

Shaaban

Aref

Taalab

et al. 2020

Asian Pac J Cancer Prev

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Background: The impact of low expression of Glutathione peroxidase 3 (GPX3) on the clinical course of acute myeloid leukemia (AML) is poorly investigated. Aims: To explore the status of GPX3 expression and analyze its clinical characteristics and prognosis in a cohort of Egyptian patients with AML. Methods: GPX3 mRNA level was assessed by RT-q PCR in 40 newly diagnosed AML patients and 10 healthy controls. Results: The gene expression level was significantly lower in AML patients than the control group (P < 0.001). A cut off value (0.1223) for the discrimination between AML and controls was obtained by ROC curve. According to this cutoff value; the patients were reassigned into 2 groups; 28 patients with lower GPX3 expression and 12 patients with high GPX3 expression. GPX3 low expression was significantly associated with higher incidence of induction death (P= 0.037) and lower CR rate (P=0.048). Moreover, GPX3 low expression was significantly associated with shorter cumulative 1-year overall survival (OS) (P = 0.001) and disease-free survival (DFS) (P=0.028). Conclusion: GPX3 low expression status is considered a poor prognostic factor in AML predicting shorter OS and DFS. The study highlights the importance of targeting glutathione metabolism as a central component of the anti-leukemia therapy.

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Section: Discussionmentioning

confidence: 99%

Implications of Glutathione Peroxidase 3 Expression in a Cohort of Egyptian Patients with Acute Myeloid Leukemia

Shaaban

Aref

Taalab

et al. 2020

Asian Pac J Cancer Prev

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“…Vimentin is also an important mesenchymal cell marker of EMT, which serves an important role in maintaining interstitial cell characteristics. Studies have confirmed that the increased expression of Vimentin is also associated with tumor invasion and metastasis (10).…”

Section: Introductionmentioning

confidence: 93%

“…Following the onset of EMT, E-cadherin is translated into N-cadherin, which is expressed in interstitial cells. Consequently the deletion and downregulation of E-cadherin is considered to be an important marker of EMT (10). Vimentin is also an important mesenchymal cell marker of EMT, which serves an important role in maintaining interstitial cell characteristics.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑124 regulates TRAF6 expression and functions as an independent prognostic factor in colorectal cancer

et al. 2019

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An increasing number of studies have confirmed that miR-124 exhibits a suppressive role in glioblastoma, cervical cancer and breast cancer; however, the function of miR-124 in colorectal cancer (CRC) has not been completely elucidated. In the present study, miR-124 expression was confirmed by reverse transcription-quantitative PCR in 80 colorectal tissues and para-cancerous tissues. The influence of altered miR-124 expression was analyzed by statistical approaches including Cox multivariate regression analysis and the Kaplan-Meier method, and the target genes of miR-124 were confirmed by luciferase reporter assays. Immunohistochemical techniques were also performed in order to measure the expression levels of target proteins. miR-124 expression was observed to be decreased in colorectal tissue samples, and this phenomenon was correlated with adverse clinical indicators and poor patient survival time. Luciferase reporter assays indicated that miR-124 directly regulated TNF receptor associated factor 6 (TRAF6) 3′-untranslated region (UTR). Hence, it was proposed that miR-124 dysregulation may negatively influence the expression of TRAF6 and therefore serve as a biomarker of epithelial-mesenchymal transition in CRC tissues. In summary, the present study demonstrated that miR-124 regulates the expression of TRAF6, and may potentially function as an independent prognostic factor and therapeutic target in patients with CRC.

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“…For example, in prostate cancer cells, TGZ inhibited both of these processes via upregulation of the canonical epithelial marker E‐cadherin, and glutathione peroxidase 3. [ 54 ] Likewise, in glioma, treatment with TGZ impaired TGF‐β ‐induced migration and invasion while reducing the overall proliferative capacity of the tumor cells. [ 55 ] Also, in breast cancer, TGZ impaired tumor cell invasion by inhibiting matrix metalloproteinase‐9 (MMP‐9).…”

Section: Signaling Pathways As Potent Targets For Differentiation Therapymentioning

confidence: 99%

Critical regulatory levels in tumor differentiation: Signaling pathways, epigenetics and non‐coding transcripts

et al. 2021

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Approaches to induce tumor differentiation often result in manageable and therapynaïve cellular states in cancer cells. This transformation is achieved by activating pathways that drive tumor cells away from plasticity, a state that commonly correlates with enhanced aggression, metastasis and resistance to therapy. Here, we discuss signaling pathways, epigenetics and non-coding RNAs as three main regulatory levels with the potential to drive tumor differentiation and hence as potential targets in differentiation therapy approaches. The success of an effective therapeutic regimen in one cancer, however, does not necessarily sustain across cancer types; a phenomenon largely resulting from heterogeneity in the genetic and physiological landscapes of tumor types necessitating an approach designed for each cancer's unique genetic and phenotypic build-up.

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Troglitazone inhibits the migration and invasion of PC‑3 human prostate cancer cells by upregulating E‑cadherin and glutathione peroxidase 3

Cited by 16 publications

References 47 publications

Implications of Glutathione Peroxidase 3 Expression in a Cohort of Egyptian Patients with Acute Myeloid Leukemia

Implications of Glutathione Peroxidase 3 Expression in a Cohort of Egyptian Patients with Acute Myeloid Leukemia

MicroRNA‑124 regulates TRAF6 expression and functions as an independent prognostic factor in colorectal cancer

Critical regulatory levels in tumor differentiation: Signaling pathways, epigenetics and non‐coding transcripts

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