Trojan nanobacteria hybridized with prodrug nanocapsules for efficient combined tumor therapy

Zang, Mingsong; Ji, Yuancheng; Ding, Xiaoran; Xu, Zhengwei; Hou, Jinxing; Sun, Jianxin; Xu, Jing; Yu, Shuangjiang; Sun, Hongcheng; Wang, Tingting

doi:10.1007/s12274-023-5503-7

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…This work provided an innovational strategy for intelligent living bacteria combined with NPs to improve antitumor radio-sensitization. A recent study [149] put forward hybrid nanobacteria through self-assembly cisplatin prodrug nanocapsules conjugating with E. coli MG1655 via amination reaction. E. coli-loading nanocapsules moved and colonized to the tumor sites and exhibited significant anticancer ability in vitro and in vivo.…”

Section: Chemical Bondsmentioning

confidence: 99%

Bacteria and Bacterial Components as Natural Bio-Nanocarriers for Drug and Gene Delivery Systems in Cancer Therapy

Zong,

Ruan,

Liu

et al. 2023

Pharmaceutics

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Bacteria and bacterial components possess multifunctional properties, making them attractive natural bio-nanocarriers for cancer diagnosis and targeted treatment. The inherent tropic and motile nature of bacteria allows them to grow and colonize in hypoxic tumor microenvironments more readily than conventional therapeutic agents and other nanomedicines. However, concerns over biosafety, limited antitumor efficiency, and unclear tumor-targeting mechanisms have restricted the clinical translation and application of natural bio-nanocarriers based on bacteria and bacterial components. Fortunately, bacterial therapies combined with engineering strategies and nanotechnology may be able to reverse a number of challenges for bacterial/bacterial component-based cancer biotherapies. Meanwhile, the combined strategies tend to enhance the versatility of bionanoplasmic nanoplatforms to improve biosafety and inhibit tumorigenesis and metastasis. This review summarizes the advantages and challenges of bacteria and bacterial components in cancer therapy, outlines combinatorial strategies for nanocarriers and bacterial/bacterial components, and discusses their clinical applications.

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Section: Chemical Bondsmentioning

confidence: 99%

Bacteria and Bacterial Components as Natural Bio-Nanocarriers for Drug and Gene Delivery Systems in Cancer Therapy

Zong,

Ruan,

Liu

et al. 2023

Pharmaceutics

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Nanomedicine hitchhiking on bacteria for treating tumors

Zheng,

Li,

Guo

2024

BMEMat

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Nanomedicine has shown promising therapeutic potential in cancer treatment, with clinically approved formulations such as Doxil® and Abraxane® already providing tangible benefits to patients. However, challenges such as low targeting efficiency and poor tumor penetration limit its application. Bacteria have emerged as promising drug delivery carriers due to their capacity for autonomous navigation and deep penetration into hypoxic tumor parenchyma. Therefore, utilizing bacteria as carriers for nanomedicine can partially overcome the limitations of anti‐tumor nanomedicine. Moreover, some bacteria, like Salmonella typhimurium and Escherichia coli, exhibit immunostimulatory and oncolytic effects and can synergistically enhance the anti‐tumor effects of nanomedicine. This article summarizes common types of bacteria and nanomedicines and their respective advantages and challenges in cancer treatment. It elaborates on various strategies for combining bacteria and nanomedicine under different administration routes, outlining the clinical progress and challenges of bacterial anti‐tumor therapy and outlooking for future applications of utilizing bacteria as carriers for nanomedicine in cancer treatment.

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