Trombosed solitary angiokeratoma of Mibelli simulating malignant melanoma: the importance of dermoscopy in differential diagnosis

Şahin, Murat; Türel‐Ermertcan, A; Öztürkcan, Serap; Türkdoğan, Peyker

doi:10.1111/j.1468-3083.2005.01299.x

Cited by 19 publications

(16 citation statements)

References 4 publications

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“…Recently, dermoscopy has become a very useful method for the preoperative diagnosis of vascular lesions including AKs1. Zaballos et al2 categorized three dermoscopic patterns of AKs, consisting of dark or red lacunae, a whitish veil, and peripheral erythema with a hemorrhagic crust2,3. In this study we present two cases of AKs diagnosed usefully as dermoscopic patterns.…”

Section: Introductionmentioning

confidence: 85%

Dermoscopy: A Useful Tool for the Diagnosis of Angiokeratoma

Kim

Lee

et al. 2012

Ann Dermatol

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Angiokeratoma is a rare vascular malformation of the upper dermis that presents clinically as deep red to blue-black in color and tends to take a diverse configuration without self-limiting. Here, we reported dermoscopic findings by two cases of angiokeratoma; solitary angiokeratoma and angiokeratoma circumscriptum. A 24-year-old male presented with a 2-months history of 5 mm sized black colored papule on the right buttock. A dermoscopic pattern characterized by red and dark lacunae, whitish veil covered with scale. A 26-year-old woman presented with multiple, 2~10 mm, dark colored papules on the anterior neck with zosteriform fashion since childhood. A dermoscopic pattern presented by red lacunae intermingled with whitish veil. As a previous report, our two cases was the most common dermoscopic pattern of angiokeratoma; red lacunae and whitish veil. Angiokeratoma is often diagnosed as melanocytic nevi, Spitz nevi, malignant melanomas, pigmented basal cell carcinomas, seborrheic keratoses, dermatofibromas and other vascular lesions including hemangiomas and pyogenic granulomas. However, in the dermoscopic view, these above lesions hardly show red lacunae with whitish veils. Therefore, the dermscopic view is a useful differential method of angiokeratoma.

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Section: Introductionmentioning

confidence: 85%

Dermoscopy: A Useful Tool for the Diagnosis of Angiokeratoma

Kim

Lee

et al. 2012

Ann Dermatol

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“…Angiokeratoma of Mibelli usually presents as grouped asymptomatic blue‐black papules on the dorsum of hands and feet in females, manifesting typically between 10 and 15 years of age. There may be a familial predisposition and an association with chilblains, acrocyanosis or trauma 52 …”

Section: Angiokeratoma In Other Rare Lysosomal Storage Disordersmentioning

confidence: 99%

Angiokeratoma: decision-making aid for the diagnosis of Fabry disease

Zampetti

Orteu

Antuzzi

et al. 2012

British Journal of Dermatology

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Isolated angiokeratomas are common benign cutaneous lesions, generally deemed unworthy of further investigation. In contrast, diffuse angiokeratomas should alert the physician to a possible diagnosis of Fabry disease, a rare X-linked lysosomal storage disorder, characterized by α-galactosidase deficiency. Glycosphingolipids accumulate in cells throughout the body resulting in progressive multi-organ failure. Difficulties are encountered when trying to interpret the significance of angiokeratomas because they may also occur in other lysosomal storage disorders and rarely in an isolated manner in Fabry disease. We present an algorithm for the classification of angiokeratomas which might prove useful for the diagnosis and management of Fabry disease. Assessment of the clinical features and location of the lesions, personal and family history, skin biopsy, dermoscopy and electron microscopy imaging are sequential steps in the diagnostic process. Assessing the deficiency of α-galactosidase enzyme activity is essential to confirm the diagnosis in males, while mutation analysis is always needed in females. Potentially this algorithm can change the current approach to patients when Fabry disease is suspected, thus improving the diagnostic strategy and management of this disorder. It remains to be decided whether the use of an algorithm might reduce the number of genetic consultations. As evidence has shown the efficacy of enzyme replacement therapy in halting progression of the disease before the onset of irreversible organ damage, it is advisable to aim at an early diagnosis in order to achieve timely initiation of effective treatment with benefits for patients and appropriate use of medical resources.

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“…Angiokeratoma of Mibelli, reported by Bazin in 1862 and defined by Mibelli in 1889, characterized by papules or verrucoid nodules, more commonly in men and involving bony prominences[2]Angiokeratoma of Fordyce, described by Fordyce in 1896, common in elderly males, located in scrotum, thighs, abdomen and groins and vulva in women, usually related to conditions with elevated venous pressure[3]Angiokeratoma circumscriptum, first reported by Fabry in 1915, usually presenting as papules with a tendency to confluence into plaques[4]Solitary or multiple (papular) types, usually involving lower extremitiesAngiokeratoma corporis diffusum, consisting of multiple papules in clusters, usually associated with Anderson Fabry's disease. …”

mentioning

confidence: 99%

“…Angiokeratoma of Mibelli, reported by Bazin in 1862 and defined by Mibelli in 1889, characterized by papules or verrucoid nodules, more commonly in men and involving bony prominences[2]…”

mentioning

confidence: 99%