Tropane Alkaloids fromErythroxylumGenus: Distribution and Compilation of¹³C‐NMR Spectral Data

Abstract

Erythroxylum, the most representative genus of the Erythroxylaceae family, presents tropane alkaloids as main constituents. This class of compounds greatly contributes to the chemotaxonomic characterization of plants of this genus, and it has important medical uses and shows toxic effects. This review describes 186 tropane alkaloids in the 35 species of Erythroxylum distributed worldwide. In addition, a compilation of their (13)C-NMR spectral data is presented.

Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010

“…In the course of our continuing search for bioactive natural plant products, we have published reviews on crude plant extracts and plant-derived compounds with potential uses [ 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. Moreover, our group has also reviewed the medicinal and poisonous plants of Northeast Brazil [ 38 , 39 ], among others [ 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. Recently we published a review on the anti-inflammatory activity of alkaloids reported in the twentieth century, more precisely covering the period from 1907 to 2000 [ 53 ].…”

Cytotoxic Evaluation of Pungencine: A New Tropane Alkaloid from the Roots of Erythroxylum pungens O. E. Schulz

“…Recently, our research group has published a review on 13 C-NMR data of tropane alkaloids from the Erythroxylum genus and of ecdysteroids in Vitex (Verbenaceae) species [4] [5]. This type of investigation permits an efficient way to identify a specific type of compounds present in plants.…”

Tropane Alkaloids from Erythroxylum caatingaePlowman

“…The 13 C-NMR spectrum of 1 showed signals at d(C) 60.1 (C(1)), 65.7 (C(5)), and 40.1 (MeN), characteristics of a tropane skeleton. In addition, the signals at d(C) 67.3 and 79.7 are compatible with the tropane skeleton substituted at C(3) and C(6) [7]. The HSQC spectrum showed direct correlations between d(C) 60.1 (C(1)) and d(H) 3.45 (HÀC(1)), and 65.7 (C(5)), and 3.43 (HÀC (5)).…”

“…), 1.82 and 2.03 (H eq ÀC(2) and H eq ÀC(4), resp. ), and 2.33 and 2.82 (H a ÀC (7) and H b ÀC(7), resp. ), and a MeN group at d(H) 2.46.…”