PLASMA INSULIN IN DIABETES MELLITUS BRmSH MEDICAL JOURNALThe first is severe and is chairacterized by weight loss and ketosis as well as hyperglycaemia; it occurs at any age, but mainly in the young, and their plasma contains no available insulin but renders the rats insensitive to subsequent insulin injections. They require insulin treatment to live.The second type consists mainly of middle-aged obese diabetics, females being more numerous, and is distinguished by the absence of ketosis and loss of weight. Their plasma contains available insulin, roughly 70% of normal controls, but does not make rats insensitive to insulin. Their diabetic state is easily controlled by diet alone, especially when obesity is thereby reduced.