TRPM8 channels: A review of distribution and clinical role

Liu, Yuqian; Mikrani, Reyaj; He, Yanjun; Baig, Mirza Muhammad Faran Ashraf; Abbas, Muhammad; Naveed, Muhammad; Tang, Meirong; Zhang, Qin; Li, Cuican; Zhou, Xiaohui

doi:10.1016/j.ejphar.2020.173312

Cited by 79 publications

(64 citation statements)

References 159 publications

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“…In this study, we focused on a mutation in TRPM8, a gene of which is known to be expressed in the trigeminal and dorsal root ganglia. [7][8][9] TRPM8 is an outwardly rectifying nonselective Ca 2+ channel, first characterized as a neuronal detector of cold. 32,33 It is activated by cold temperatures (<26°C) and compounds that produce a cooling sensation such as menthol, icilin, and eucalyptol.…”

Section: Discussionmentioning

confidence: 99%

“…6 Notably, the patient was heterozygous for a variant, c.89 G > A (p.Arg30Gln; 9/ 282,688 on gnomAD v2), in TRPM8. Given the expression of TRPM8 within trigeminal ganglia [7][8][9] and reported association of TRPM8 with pain, [10][11][12] we asked whether this variant might produce any functional changes in the TRPM8 channel or within cells expressing it.…”

Section: Patientmentioning

confidence: 99%

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Trigeminal Neuralgia TRPM8 Mutation

et al. 2021

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ObjectiveTo assess the functional effects of a variant, c.89 G > A (p.Arg30Gln), in the transient receptor potential melastatin 8 (TRPM8) cold-sensing, nonselective cation channel, which we have previously identified in a patient with familial trigeminal neuralgia.MethodsWe carried out Ca2+ imaging and whole-cell patch-clamp recording.ResultsThe TRPM8 mutation enhances channel activation, increases basal current amplitude and intracellular [Ca2+] in cells carrying the mutant channel, and enhances the response to menthol.ConclusionsWe propose that Arg30Gln confers gain-of-function attributes on TRPM8, which contribute to pathogenesis of trigeminal neuralgia in patients carrying this mutation.

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Section: Discussionmentioning

confidence: 99%

Section: Patientmentioning

confidence: 99%

Trigeminal Neuralgia TRPM8 Mutation

et al. 2021

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“…Therefore, an appropriate amount of physical activity for increasing muscle strength might be needed to prevent sensitivity to cold. Transient receptor potential melastatin 8 (TRPM8) is widely distributed in the human body [20]. In skeletal muscle, detection of 10 different TRP channels has been reported [21].…”

Section: Discussionmentioning

confidence: 99%

Associations between Sensitivity to Cold, Menstruation-Related Symptoms and Handgrip Strength in Female University Students in Japan

Matsuura¹,

Akamine²,

Murakami³

et al. 2021

Health

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Sensitivity to cold, which is a popular symptom in Japanese women, is associated with various symptoms such as shoulder stiffness and general fatigue. However, an association of sensitivity to cold with muscle strength has not been reported. The aim of the study was to clarify the associations of sensitivity to cold with handgrip strength and with menstruation-related symptoms in female university students in Japan. We recruited 278 female university students in Japan. Sensitivity to cold and menstruation-related symptoms including physical and psychological symptoms were assessed by using a self-administered questionnaire that we designed. Handgrip strength was measured by using a handgrip strength dynamometer. We received responses from 269 students. The prevalence rate of sensitivity to cold in the subjects was 54.3%. The students who had sensitivity to cold had a lower handgrip strength level (25.5 ± 3.8 kg) than did the students who did not have sensitivity to cold (26.7 ± 3.9 kg) (p = 0.017). Sensitivity to cold was associated with low body mass index. In addition, the students who had sensitivity to cold tended to have low back pain and constipation during menstruation. In conclusion, sensitivity to cold is an important symptom associated with muscle strength as well as menstruation-related symptoms for young women.

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“…Activation of TRPM8 relieves itching in various ways [ 64 ]. First, it activates the kappa opioid antipruritic receptor [ 65 ]. The influx of TRPM8-related calcium into neurons increases the threshold for itching [ 66 ].…”

Section: Treatment Of Itch In Elderlymentioning

confidence: 99%

Pathophysiology and Treatment of Pruritus in Elderly

Chung

Kim

et al. 2020

IJMS

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Pruritus is a relatively common symptom that anyone can experience at any point in their life and is more common in the elderly. Pruritus in elderly can be defined as chronic pruritus in a person over 65 years old. The pathophysiology of pruritus in elderly is still unclear, and the quality of life is reduced. Generally, itch can be clinically classified into six types: Itch caused by systemic diseases, itch caused by skin diseases, neuropathic pruritus, psychogenic pruritus, pruritus with multiple factors, and from unknown causes. Senile pruritus can be defined as a chronic pruritus of unknown origin in elderly people. Various neuronal mediators, signaling mechanisms at neuronal terminals, central and peripheral neurotransmission pathways, and neuronal sensitizations are included in the processes causing itch. A variety of therapies are used and several novel drugs are being developed to relieve itch, including systemic and topical treatments.

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TRPM8 channels: A review of distribution and clinical role

Cited by 79 publications

References 159 publications

Trigeminal Neuralgia TRPM8 Mutation

Trigeminal Neuralgia TRPM8 Mutation

Associations between Sensitivity to Cold, Menstruation-Related Symptoms and Handgrip Strength in Female University Students in Japan

Pathophysiology and Treatment of Pruritus in Elderly

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