TRPP2 and TRPV4 form a polymodal sensory channel complex

Köttgen, Michael; Buchholz, Björn; García-González, Miguel A.; Kotsis, Fruzsina; Fu, Xiaohua; Doerken, Mara; Boehlke, Christopher; Steffl, Daniel; Tauber, Robert; Węgierski, Tomasz; Nitschke, Roland; Suzuki, Makoto; Kramer-Zucker, Albrecht; Germino, Gregory G.; Watnick, Terry; Prenen, Jean; Nilius, Bernd; Kuehn, E. Wolfgang; Walz, Gerd

doi:10.1083/jcb.200805124

Cited by 356 publications

(307 citation statements)

References 45 publications

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“…In isolated thick ascending limbs, ATP secretion is substantially reduced following blockade or siRNA knockdown of TRPV4 [337]. Similar data were obtained in MDCK cells [198], and here TRPV4 colocalises in cilia with polycystin 2. Polycystin 2 is an ion channel devoid of intrinsic mechanosensitive properties but forms with TRPV4 in the cilium base a complex allowing Ca 2+ influx when the cilium is bent.…”

Section: Flow-induced Nucleotide Releasesupporting

confidence: 86%

Purinergic signalling in the kidney in health and disease

Burnstock

Evans

Bailey

2013

Purinergic Signalling

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The involvement of purinergic signalling in kidney physiology and pathophysiology is rapidly gaining recognition and this is a comprehensive review of early and recent publications in the field. Purinergic signalling involvement is described in several important intrarenal regulatory mechanisms, including tuboglomerular feedback, the autoregulatory response of the glomerular and extraglomerular microcirculation and the control of renin release. Furthermore, purinergic signalling influences water and electrolyte transport in all segments of the renal tubule. Reports about purine-and pyrimidine-mediated actions in diseases of the kidney, including polycystic kidney disease, nephritis, diabetes, hypertension and nephrotoxicant injury are covered and possible purinergic therapeutic strategies discussed.

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Section: Flow-induced Nucleotide Releasesupporting

confidence: 86%

Purinergic signalling in the kidney in health and disease

Burnstock

Evans

Bailey

2013

Purinergic Signalling

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“…Hypotonic conditions cause cell swelling and membrane stretch, resulting in an activation of MS channels. 19,20 Thus the current induced by hypotonic stimulations is thought to be due to an activation of MCA1 expression-dependent MS channels. It should be noticed that the inward currents were also increased slightly under hypotonic conditions in water-injected oocytes probably due to the activation of endogenous MS channels (Fig.…”

Section: Resultsmentioning

confidence: 99%

Expression of Arabidopsis MCA1 enhanced mechanosensitive channel activity in theXenopus laevisoocyte plasma membrane

Furuichi

Iida

Sokabe

et al. 2012

Plant Signaling & Behavior

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“…Fluid flow was also reported to induce an increase in intracellular calcium in human MSCs [3]. Furthermore, TRP channels located in the cilia can transduce the mechanical stimulation to calcium signals [28].…”

Section: Pressure Induces Trpm7-dependent Osteogenic Gene Expressionmentioning

confidence: 98%

Brief Reports: TRPM7 Senses Mechanical Stimulation Inducing Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells

et al. 2015

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Mesenchymal stem cells (MSCs) are multipotential stem cells residing in the bone marrow. Several studies have shown that mechanical stimulation modulates MSC differentiation through mobilization of second messengers, but the mechanism of mechanotransduction remains poorly understood. In this study, using fluorescence and laser confocal microcopy as well as patchclamp techniques, we identified the transient receptor potential melastatin type 7 (TRPM7) channel as the key channel involved in mechanotransduction in bone marrow MSCs. TRPM7 knockdown completely abolished the pressure-induced cytosolic Ca 21 increase and pressureinduced osteogenesis. TRPM7 directly sensed membrane tension, independent of the cytoplasm and the integrity of cytoskeleton. Ca 21 influx through TRPM7 further triggered Ca 21 release from the inositol trisphosphate receptor type 2 on the endoplasmic reticulum and promoted NFATc1 nuclear localization and osteogenesis. These results identified a central role of TRPM7 in MSC mechanical stimulation-induced osteogenesis. STEM CELLS 2015;33:615-621

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TRPP2 and TRPV4 form a polymodal sensory channel complex

Abstract: Abbreviations used in this paper: FRET, fl uorescence resonance energy transfer; hpf, hours postfertilization; MO, morpholino oligonucleotide; RR, ruthenium red; TRP, transient receptor potential.The online version of this paper contains supplemental material.

Cited by 356 publications

References 45 publications

Purinergic signalling in the kidney in health and disease

Purinergic signalling in the kidney in health and disease

Expression of Arabidopsis MCA1 enhanced mechanosensitive channel activity in theXenopus laevisoocyte plasma membrane

Brief Reports: TRPM7 Senses Mechanical Stimulation Inducing Osteogenesis in Human Bone Marrow Mesenchymal Stem Cells

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