Tru-cut biopsy as the initial method of tissue diagnosis in bone tumors with soft tissue extension

Abstract

Background:Tru-cut biopsy in suspected bone tumors can be performed even in less specialized centers. Tru-cut biopsy has been proved as safe with more than 90% accuracy. However, its usefulness was not widely studied in general hospitals where Tru-cut biopsy is performed by orthopedic surgeons. This study was conducted to find out the accuracy and adequacy of Tru-cut biopsy performed by an orthopedic surgeon not trained in musculoskeletal oncology, in a general hospital.Materials and Methods:A study was conducted through a prospectively collected database using a uniform protocol. All patients who had a malignant appearing bone lesion with a palpable soft tissue mass were included in the current study. Fifty such consecutive cases underwent Tru-Cut biopsy by orthopedic residents or registrars who were aware of the principles of Tru-cut biopsy and the recommendations of Musculoskeletal Tumor Society. When an open biopsy or a resection of the tumor was subsequently performed, the histological diagnosis was compared for accuracy with the diagnosis of needle biopsy. We evaluated adequacy of sample obtained and accuracy of diagnosis in terms of sensitivity, specificity, positive predictive value, and negative predictive value.Results:Seventy seven cases were initially enrolled. Out of which 18 were excluded and 59 patients were biopsied. Out of which 50 were analysed. Only 4 out of 50 biopsied specimens were inadequate resulting in an adequacy rate of 92%. Among 46 cases, which were analyzed for diagnostic accuracy, 84.78% had true-positive result, 8.69% had true negative, and 6.52% had false-negative report. The sensitivity and specificity of Tru-cut biopsy in our series was 92.85% and 100%, respectively, with positive predictive value of 100% and negative predictive value of 57.14%.Conclusions:Tru-cut biopsy can be recommended as an initial method of tissue diagnosis in musculoskeletal tumors with soft tissue extension.

Kemik ve yumuşak doku tümörlerinde biyopsi

“…Palpe edilen yumuşak doku komponenti olan lezyonlarda yardımcı görüntüleme yöntemleri kullanılmadan başarılı bir şekilde yapılabilir. [2] Ulaşılması zor olan bölgelere (pelvis, vertebra) BT, MR ve US eşliğinde ulaşma olanağı sağlar (Şekil 4). [10][11][12] Metastatik lezyon, enfeksiyon ve lokal nüks olan tümörlerde doğruluğu en yüksek iken, deneyimsiz bir cerrah tarafından yapılması teknik olarak zordur ve tümör hücrelerinin sağlıklı dokulara bulaşmasına neden olabilir.…”

“…Uygun olmayan biyopsi tedaviye yarardan daha çok zarar vereceğinden temel eğitimin alınmış olması veya asıl tedaviyi üstlenecek merkezlerde yapılması şarttır. [1,2] Multidisipliner yaklaşım olmadan verilmiş biyopsi kararı bazen gereksiz yere bazen de yanlış yerden örnek alınmasına neden olabilir. Asıl tedavide kullanılacak insizyonun dışında bir insizyon kullanılması ya da alınmış örneği değerlendiren patoloji uzmanına doğru klinik bilgi verilmemesi, dönüşü olmayan hatalara yol açabilir.…”

Combined CT guided tru-cut biopsy and imprint cytology in the diagnosis of bone tumors and tumor like lesions

“…Joshi A et al found the sensitivity and specificity of Tru-cut biopsy of palpable bone lesions with soft tissue extension in their series was 92.85% and 100%, respectively, with positive predictive value of 100% and negative predictive value of 57.14%. 1 However guided biopsies are becoming popular as they can hit the lesion more accurately in many cases. Ultrasound guided tru-cut biopsies were done by Saifiddin et al in lesions with relatively large extraosseous component.…”

To study the effectiveness of core needle biopsy in diagnosing bone lesions in patients attending tertiary care centre, Telangana State, South India

“…It is very important to differentiate between benign and malignant conditions before treating it. Diagnosis and treatment involves team of specialists involving pathologists, radiologists, surgeons in managing the bone tumours [1][2][3][4] . Preoperative histopathological diagnosis is corner stone, which are most definitive methods of preoperative diagnosis [4][5][6].…”