This paper presents an effort to address urgent issues associated with semitruck platooning. The weigh-in-motion data was first examined to determine the characteristics of naturally formed semitruck platoons. A safety-based two-vehicle platoon model was then utilized to determine the critical headways for assessing the safety of semitruck platooning in various driving scenarios. The possibilities for passenger vehicles to cut into semitruck platoons were assessed using actual vehicle headway data. Finally, the potential impacts of semitruck platooning on typical interstate highway pavements were assessed using finite element analysis. Most semitruck platoons consist of 2 to 3 vehicles. An optimal platoon gap of 0.94 s was identified for connected and automated semitruck platooning. The potential impacts of truck platooning on concrete pavement were negligible for a platoon gap greater than 0.2 s. The maximum possible impact was less than 4% in terms of the service life reduction for interstate asphalt pavement.