True color scanning laser ophthalmoscopy and optical coherence tomography handheld probe

Larocca, Francesco; Nankivil, Derek; Farsiu, Sina; Izatt, Joseph A.

doi:10.1364/boe.5.003204

Cited by 28 publications

(29 citation statements)

References 34 publications

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“…For handheld OCT systems, manually focusing tuning mechanisms have been demonstrated [13][14][15][16][17][18]. The manual focusing procedure is slow, and usually, the results are not ideal because the operator has to, subjectively, decide if the image is in focus or not.…”

Section: Golden-section Search Based Automatic Focus Tuningmentioning

confidence: 99%

“…Wide-field en face images (10 × 10 mm 2 ) of the human retina were retrieved from the handheld OCT instrument [15]. Besides, a series of research works on the development of handheld scanning laser ophthalmoscopy (SLO) and OCT probe have demonstrated by researchers at Duke University [16,17]. Most recently, they observed the retinal photoreceptor cells of young children based on their welldeveloped handheld probe and SLO imaging technique [18].…”

Section: Introductionmentioning

confidence: 99%

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Handheld optical coherence tomography angiography

Yang

Liu

Campbell

et al. 2017

Biomed. Opt. Express

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Abstract:We developed a handheld optical coherence tomography angiography (OCTA) system using a 100-kHz swept-source laser. The handheld probe weighs 0.4 kg and measures 20.6 × 12.8 × 4.6 cm 3 . The system has dedicated features for handheld operation. The probe is equipped with a mini iris camera for easy alignment. Real-time display of the en face OCT and cross-sectional OCT images in the system allows accurately locating the imaging target. Fast automatic focusing was achieved by an electrically tunable lens controlled by a goldensection search algorithm. An extended axial imaging range of 6 mm allows easy alignment. A registration algorithm using cross-correlation to register adjacent OCT B-frames with propagation from the central frame was used to effectively minimize motion artifacts in volumetric OCTA images captured in relatively short durations of 1 and 2.1 seconds. 2.5 × 2.5 mm (200 × 200 pixels) and 3.5 × 3.5 mm (300 × 300 pixels) retinal angiograms were demonstrated on two awake adult human subjects without the use of any mydriatic eye drops. Opt. Express 4(10), 1890-1908 (2013). 40. I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G.Fujimoto, "Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with verticalcavity surface emitting lasers," Biomed.

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Section: Golden-section Search Based Automatic Focus Tuningmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Handheld optical coherence tomography angiography

Yang

Liu

Campbell

et al. 2017

Biomed. Opt. Express

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“…The optics were optimized in optical design software, Zemax (Radiant ZEMAX LLC, Redmond, WA), using an eye model with a gradient index lens [13]. The eye model was modified as described in [8] with glass types adjusted to match human ocular dispersion [14]. A gimbal-less two-axis scanning MEMS micromirror (13Z1.1, Mirrorcle Technologies Inc., Richmond, CA) was used to control beam position on the subject eye.…”

Section: Optical Designmentioning

confidence: 99%

“…To mitigate some of these constraints, researchers have developed handheld OCT instruments [1][2][3][4][5][6][7][8]. A few of these instruments are capable of imaging both the anterior and posterior segment [2][3][4]7], but switching between modes requires the operator to remove and/or add an additional lens or lens system.…”

Section: Introductionmentioning

confidence: 99%

Handheld, rapidly switchable, anterior/posterior segment swept source optical coherence tomography probe

Nankivil¹,

Waterman²,

Larocca³

et al. 2015

Biomed. Opt. Express

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Abstract:We describe the first handheld, swept source optical coherence tomography (SSOCT) system capable of imaging both the anterior and posterior segments of the eye in rapid succession. A single 2D microelectromechanical systems (MEMS) scanner was utilized for both imaging modes, and the optical paths for each imaging mode were optimized for their respective application using a combination of commercial and custom optics. The system has a working distance of 26.1 mm and a measured axial resolution of 8 μm (in air). In posterior segment mode, the design has a lateral resolution of 9 μm, 7.4 mm imaging depth range (in air), 4.9 mm 6dB fall-off range (in air), and peak sensitivity of 103 dB over a 22° field of view (FOV). In anterior segment mode, the design has a lateral resolution of 24 μm, imaging depth range of 7.4 mm (in air), 6dB fall-off range of 4.5 mm (in air), depth-of-focus of 3.6 mm, and a peak sensitivity of 99 dB over a 17.5 mm FOV. In addition, the probe includes a wide-field iris imaging system to simplify alignment. A fold mirror assembly actuated by a bi-stable rotary solenoid was used to switch between anterior and posterior segment imaging modes, and a miniature motorized translation stage was used to adjust the objective lens position to correct for patient refraction between 12.6 and + 9.9 D. The entire probe weighs less than 630 g with a form factor of 20.3 x 9.5 x 8.8 cm. Healthy volunteers were imaged to illustrate imaging performance. J. G. Fujimoto, "Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror," Biomed. ©2015 Optical Society of America

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“…Supercontinuum (SC) light is a well-established technology, which finds applications in several domains ranging from chemistry to material science and imaging systems [1][2]. More specifically, its ultra-wide optical bandwidth and high average power make it an ideal tool for Optical Coherence Tomography (OCT).…”

Section: Introductionmentioning

confidence: 99%