True Detective: Unraveling Group 1 Innate Lymphocyte Heterogeneity

Riggan, Luke; Freud, Aharon G.; O’Sullivan, Timothy E.

doi:10.1016/j.it.2019.08.005

Cited by 59 publications

(74 citation statements)

References 91 publications

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“…Numbers of adipose ILC1-like cells are further increased in obese subjects with type 2 diabetes and correlate with insulin resistance [107]. A caveat with this hypothesis is that the genetic ablation tools to definitively differentiate between the contribution of each subset of group 1 ILCs to obesity-associated insulin resistance do not currently exist, and current flow cytometry-based strategies to identify human ILC1s are not specific [9]. However, these results collectively suggest that each member of the group 1 ILCs is sufficient to polarize adipose proinflammatory macrophages through HFD-induced IFN-γ production, and therefore represent a functional spectrum of cells able to contribute to insulin resistance during diet-induced obesity.…”

Section: Ilc Activation Disrupts Metabolic Homeostasis During Diet-inmentioning

confidence: 99%

“…NK cells, the original member of group 1 ILCs [4], are cytotoxic innate lymphocytes that constitutively express the transcription factor Eomes and the integrin CD49b (also known as DX5 or α 2 β 1 integrin), and survey peripheral tissues by constant circulation through the vasculature to perform host immunosurveillance against viruses and tumors [5][6][7][8]. In contrast to NK cells, ILC1s lack Eomes and CD49b expression, but express the inhibitory receptor CD200R [9]. ILC1s are long-term tissue resident in peripheral organs, and may be required to protect the host from bacterial infections at barrier sites such as the intestine [5,6,[10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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RETRACTED: Living with Yourself: Innate Lymphoid Cell Immunometabolism

Rolot

O’Sullivan

2020

Cells

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Innate lymphoid cells (ILCs) are tissue-resident sentinels of the immune system that function to protect local tissue microenvironments against pathogens and maintain homeostasis. However, because ILCs are sensitively tuned to perturbations within tissues, they can also contribute to host pathology when critical activating signals become dysregulated. Recent work has demonstrated that the crosstalk between ILCs and their environment has a significant impact on host metabolism in health and disease. In this review, we summarize studies that support evidence for the ability of ILCs to influence tissue and systemic metabolism, as well as how ILCs can be regulated by environmental changes in systemic host metabolism. We also highlight studies demonstrating how ILC- intrinsic metabolism influences their activation, proliferation, and homeostasis. Finally, this review discusses the challenges and open questions in the rapidly expanding field of ILCs and immunometabolism.

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Section: Ilc Activation Disrupts Metabolic Homeostasis During Diet-inmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

RETRACTED: Living with Yourself: Innate Lymphoid Cell Immunometabolism

Rolot

O’Sullivan

2020

Cells

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“…Although this review has focused principally on studies involving tissue-resident NKs and helper ILC1s in mice, it is important to note that similar tissue-associated populations have now been described in diverse human tissues, including the uterus, adipose, tonsils, intestines, liver, kidney, and lung (118,119). Most of these tissue-associated populations are CD56 bright , distinguishing them from highly cytotoxic CD56 dim cNKs in peripheral blood, although accurate discrimination of human trNKs and helper ILC1s is currently limited by the lack of faithful lineage-tracking markers and tools (120). Nevertheless, these tissue-associated CD56 bright populations as a whole share many similarities with mouse trNKs and helper ILC1s, including high expression of tissue residency-associated surface markers (e.g., CD69, CD49a, and CD103) and chemokine receptors (e.g., CXCR6 and CCR5), and low or no expression of CD62L and CCR7 (121).…”

Section: Resultsmentioning

confidence: 99%

Transcriptional Regulation of Mouse Tissue-Resident Natural Killer Cell Development

Valero-Pacheco

Beaulieu

2020

Front. Immunol.

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Natural killer (NK) cells are cytotoxic innate lymphocytes that are well-known for their ability to kill infected or malignant cells. Beyond their roles in tumor surveillance and anti-pathogen defense, more recent studies have highlighted key roles for NK cells in a broad range of biological processes, including metabolic homeostasis, immunomodulation of T cells, contact hypersensitivity, and pregnancy. Consistent with the breadth and diversity of these functions, it is now appreciated that NK cells are a heterogeneous population, comprised of specialized and sometimes tissue-specific subsets with distinct phenotypes and effector functions. Indeed, in addition to the conventional NK cells (cNKs) that are abundant and have been well-studied in the blood and spleen, distinct subsets of tissue-resident NK cells (trNKs) and "helper" Group 1 innate lymphoid cells (ILC1s) have now been described in multiple organs and tissues, including the liver, uterus, thymus, adipose tissue, and skin, among others. The cNK, trNK, and/or helper ILC1 populations that co-exist in these various tissues exhibit both common and distinct developmental requirements, suggesting that a combination of lineage-, subset-, and tissue-specific differentiation processes may contribute to the unique functional properties of these various populations. Here, we provide an overview of the transcriptional regulatory pathways known to instruct the development and differentiation of cNK, trNK, and helper ILC1 populations in specific tissues in mice.

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“…IFN-γ is a type II IFN and the sole member of this family. A broad range of cells produce IFN-γ, and significant contributing populations include CD4 + T helper type I lymphocytes, CD8 + cytotoxic lymphocytes, group 1 innate lymphoid cells (ILC1s) and NK cells, as well as antigen-presenting cells, B lymphocytes, neutrophils, and NK T lymphocytes (Fenimore, 2016;Riggan, Freud, & O'Sullivan, 2019;Varma, Lin, Toliver-Kinsky, & Sherwood, 2002). IFN-γ production by neutrophils occurs during Streptococcus pneumoniae pneumonia (Gomez et al, 2015).…”

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confidence: 99%

Effects of IFN‐γ on immune cell kinetics during the resolution of acute lung injury

et al. 2020

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The immunologic responses that occur early in the acute respiratory distress syndrome (ARDS) elicit immune‐mediated damage. The mechanisms underlying the resolution of ARDS, particularly the role of signaling molecules in regulating immune cell kinetics, remain important questions. Th1‐mediated responses can contribute to the pathogenesis of acute lung injury (ALI). Interferon‐gamma (IFN‐γ) orchestrates early inflammatory events, enhancing immune‐mediated damage. The current study investigated IFN‐γ during resolution in several experimental models of ALI. The absence of IFN‐γ resulted in altered kinetics of lymphocyte and macrophage responses, suggesting that IFN‐γ present in this microenvironment is influential in ALI resolution. Genetic deficiency of IFN‐γ or administering neutralizing IFN‐γ antibodies accelerated the pace of resolution. Neutralizing IFN‐γ decreased the numbers of interstitial and inflammatory macrophages and increased alveolar macrophage numbers during resolution. Our results underline the complexity of lung injury resolution and provide insight into the effects through which altered IFN‐γ concentrations affect immune cell kinetics and the rate of resolution. These findings suggest that therapies that spatially or temporally control IFN‐γ signaling may promote ALI resolution. Identifying and elucidating the mechanisms critical to ALI resolution will allow the development of therapeutic approaches to minimize collateral tissue damage without adversely altering the response to injury.

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True Detective: Unraveling Group 1 Innate Lymphocyte Heterogeneity

Cited by 59 publications

References 91 publications

RETRACTED: Living with Yourself: Innate Lymphoid Cell Immunometabolism

RETRACTED: Living with Yourself: Innate Lymphoid Cell Immunometabolism

Transcriptional Regulation of Mouse Tissue-Resident Natural Killer Cell Development

Effects of IFN‐γ on immune cell kinetics during the resolution of acute lung injury

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