Trypanocidal activity of ethanolic extracts of Commiphora swynnertonii Burtt on Trypanosoma congolense

Abstract

BackgroundAfrican trypanosomosis is the disease caused by extracellular protozoan parasites of the genus Trypanosoma transmitted by tsetse flies. The current study has evaluated the trypanocidal activity of Commiphora swynnertonii extracts on Trypanosoma congolense.MethodsThe effect of ethanolic stem bark and resinous extracts on motility of T. congolense was evaluated by in vitro study at concentrations of 2 mg/ml and 4 mg/ml. Then, trypanocidal activity was evaluated by drug incubation infectivity test using mice at concentrations of 0.4 mg/ml and 2 mg/ml. In both studies negative (without drug) and positive (diminazene diaceturate) controls were used.ResultsThe in vitro study showed that, ethanolic stem bark extract of C. swynnertonii at concentration of 4 mg/ml caused complete cessation of motility for T. congolense in 30 min. However, resinous ethanolic extract had delayed effect on cessation of motility of T. congolense observed at 90 and 100 min post-incubation at concentrations of 4 mg/ml and 2 mg/ml respectively. The drug incubation infectivity test study depicted that ethanolic stem bark extract at concentration of 2 mg/ml significantly (p = 0.000) reduced the infectivity of T. congolense in mice. However, it did not vary significantly (P =0.897) with group treated with diminazene diaceturate incubated mixture.ConclusionThe current study has provided evidence that, ethanolic stem bark extract of C. swynnertonii possess trypanocidal activity against T. congolense. Based on these findings, further studies are recommended to determine its potential as a lead to trypanocidal drug discovery.

Ethnobotanical survey, anthelmintic effects and cytotoxicity of plants used for treatment of helminthiasis in the Central and Kara regions of Togo

“…For examples Ceratonia siliqua extract was shown to ameliorate Schistosoma mansoni-induced liver fibrosis, while Verbascum sinaiticum and Commiphora swynnertonii exerted trypanocidal activity [23,24]. Anthelmintic effects of A. melegueta on helminth parasites, were observed by Akinsanya et al [25]. The ethanolic extract of A. melegueta also known as "grain of paradise" has antiinflammatory properties by inhibiting the activity of cyclooxygenase-2 (COX-2) enzyme [26].…”

Bio-active principles in Commiphora africana resin dichloromethane extract and their insecticidal activity against bed bugs

“…Commiphora swynnertonii Burtt. extract has been shown to possess anti-ectoparasitic and repellency activities against lice, mosquito, ticks, eas, trypanosome and mites [22,23]. Its stem bark exudate extract has high acaricidal activity against the brown ear tick (Rhipicephalus appendiculatus Neumann) and can be used in tick control [22].…”

Bio-active principles in Commiphora africana resin dichloromethane extract and their insecticidal activity against bedbugs

“…Commiphora swynnertonii Burtt. extract has been shown to possess anti-ectoparasitic and repellency activities against lice, mosquito, ticks, eas, trypanosome and mites (Edwin et al, 2017;Nagagi et al 2016). Its stem bark exudate extract has high acaricidal activity against the brown ear tick (Rhipicephalus appendiculatus Neumann) and can be used in tick control (Edwin et al 2017).…”