Trypanocidal Activity of Limonoids and Triterpenes from<i>Cedrela fissilis</i>

Leite, Ana Cristina Lima; Ambrozin, Alessandra Regina Pepe; Fernandes, João B.; Vieira, Paulo C.; Silva, Maria Fátima das Graças Fernandes da; Albuquerque, Sérgio de

doi:10.1055/s-0028-1088323

Cited by 23 publications

(32 citation statements)

References 21 publications

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“…Leaf essential oil [32] Oil from leaves and stem barks [33] 2-Pentylfuran (9) Leaf essential oil [32] Limonene (10) Leaf essential oil [32] Leaf oil [33] Bornil acetate (11) Leaf essential oil [32] α-Thujene (12) Oil from leaves and stem barks [33] Sabinene (13) β-Pinene (14) Myrcene (15) Stem bark oil α-Phellandrene (16) p-Cymene (17) Oil from leaves and stem barks 1,8-Cineole (18) Stem bark oil Acetophenone (19) Leaf oil γ-Terpinene (20) Oil from leaves and stem barks trans-Sabinenehydrate (21) Stem bark oil Terpinolene (22) Oil from leaves and stem barks Linalool (23) Stem bark oil trans-Pinocarveol (24) Stem bark oil trans-Verbenol (25) Stem bark oil Terpinen-4-ol (26) Stem bark oil α-Terpineol (27) Leaf oil Myrtenol (28) Stem bark oil trans-Piperitol (29) Stem bark oil Cuminaldehyde (30) Stem bark oil Thymol (31) Stem bark oil α-Terpinylacetate (32) Leaf oil…”

Section: Compound Plant Species Plant Part Referencesmentioning

confidence: 99%

Chemical Compounds and Biologic Activities: A Review of Cedrela Genus

et al. 2020

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The genus Cedrela P. Browne, which belongs to the Meliaceae family, has eighteen species. Trees of this genus are of economic interest due to wood quality, as well as being the focus of studies because of relevant biologic activities as in other Meliaceae species. These activities are mainly related to limonoids, a characteristic class of compounds in this family. Therefore, the aim of this review is to perform a survey of the citations in the literature on the Cedrela genus species. Articles were found on quantitative and qualitative phytochemical studies of the Cedrela species, revealing the chemical compounds identified, such as aliphatics acid and alcohol, flavonoids, tocopherol, monoterpenes, sesquiterpenes, triterpenes, cycloartanes, steroids, and limonoids. Although some activities were tested, the majority of studies focused on the insecticidal, antifeedant, or insect growth inhibitor activities of this genus. Nonetheless, the most promising activities were related to their antimalarial and antitripanocidal effects, although further investigations are still needed.

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Section: Compound Plant Species Plant Part Referencesmentioning

confidence: 99%

Chemical Compounds and Biologic Activities: A Review of Cedrela Genus

et al. 2020

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“…This species also shows significant antinociceptive and antiinflammatory activities (Guzzo et al, 2008). Rutin, quercetin, isochlorogenic acid, caffeic acid, isovitexin, vitexin, sesquiterpene derivatives (Alcântara et al, 2005;Leite et al, 2008), and the triterpenes lupeol, a mixture of α-and β-amyrin, and friedelin were previously isolated from its aerial parts. Although several studies have lately related triterpenes to treatment of the trypanosomiases (Rosas et al, 2007;Leite et al, 2006;Cunha et al, 2006) and bactericidal activity (Al-Fatimi et al, 2010), no data are available about the trypanocidal and bactericidal activities of triterpenes isolated from Lychnophora species.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the bactericidal and trypanocidal activities of triterpenes isolated from the leaves, stems, and flowers of Lychnophora pinaster

Abreu¹,

Takahashi²,

Duarte³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The phytochemical investigation on the aereal parts of Lychnophora pinaster Mart., Asteraceae, was carried to isolation of triterpenes. 3-O-Acetyllupeol (1), 3-O-acetyl-pseudotaraxasterol (2), and 3-O-acetyl-α-amyrin (3) were isolated from hexanic extract and 4,4-dimethyl-cholesta-22,24-dien-5-ol (4), α-amyrin (5), and lupeol (6) were isolated from hexanic/dichlorometanic extract of the leaves. Compounds Δ 7 -bauerenyl acetate (7), friedelin (8), stigmasterol (9), and sitosterol (10) were isolated from the hexanic/dichlorometanic extract of the stems. The steroids 9 and 10 were also isolated from the hexanic/dichlorometanic extract of the flowers. Triterpenes 1, 3, 4, and 7 are described for the first time in the genus Lychnophora. The apolar fractions of the leaf and stem extracts and some isolated triterpenes showed low trypanocidal activity. Moreover, apolar fractions of the leaf and stem extracts and 5 showed antibacterial action against Staphylococcus aureus.

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“…Para esta espécie, ainda, Seccon et al (2010) descreveram o potencial antioxidante. Leite et al (2008) citaram C. fissilis como fonte promissora de compostos ativos para o controle da doença de Chagas, por ter demonstrado efeito tripanocida. Rattmann et al (2009) realizaram estudos em ratos com extrato hidroalcoólico a partir de folhas de D. sellowiana, sugerindo que este induz a relaxamento completo vascular em anéis da aorta, bem como, produz efeito hipotensor em ratos anestesiados, podendo contribuir na gestão de diversas condições patológicas, como hipertensão e aterosclerose.…”

Section: Resultsunclassified

Potencial Terapêutico de Espécies Arbóreas em Fragmentos de Floresta Ombrófila Mista

et al. 2016

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RESUMOObjetivou-se levantar o potencial terapêutico de espécies arbóreas presentes em remanescentes de Floresta Ombrófila Mista (FOM) localizados no Planalto Sul Catarinense, destacando as que possuem ações terapêuticas atestadas em ensaios científicos, assim como, aquelas com potencial medicinal segundo registros etnobotânicos. Para amostrar a composição florística arbórea foi empregado o método de quadrantes, registrando-se os indivíduos mais próximos do ponto central, que apresentassem DAP ≥ 5 cm. A amostragem foi realizada em Áreas de Preservação Permanente (APP's) e/ou Reserva Legal, com o auxílio de 20 transecções contendo 20 pontos quadrantes cada, totalizando 2,61 hectares. Dentre as 97 espécies registradas e identificadas no levantamento, 16 possuem ação medicinal descrita e atestada em literatura e 12 espécies são descritas como potenciais de acordo com conceitos etnobotânicos. O presente estudo mostrou que pequenos remanescentes florestais podem contribuir para a manutenção de espécies da FOM e basear futuros estudos sobre plantas medicinais ou com outros potenciais bioativos.Palavras-chave: floresta com araucária, conservação florestal, etnobotânica. Therapeutic Potential of Tree Species in Araucaria Forest Fragments ABSTRACTThis study aimed to evaluate the medicinal potential of tree species in Araucaria Forest (FOM) remnants in Santa Catarina Plateau, highlighting those with therapeutic actions attested in scientific trials, as well as those with medicinal potential according to ethnobotanical records. The floristic composition was sampled through the point-centered quarter method, registering the individuals with DBH ≥ 5 cm closest to the center point. Sampling was conducted in Permanent Preservation Areas (APP's) and/or Legal Reserve, with the help of 20 transects with 20 points quadrants each, totaling 2.61 hectares. Among the species recorded and identified, 16 of them, classified into 13 plant families, have medicinal potential described and attested in literature and 12 species within 10 families, are suggested as potential, according to ethnobotanical concepts. The present study showed that these sites may contribute to the maintenance of species of FOM and to base future studies on medicinal plants and/or other bioactive potential.

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Trypanocidal Activity of Limonoids and Triterpenes fromCedrela fissilis

Cited by 23 publications

References 21 publications

Chemical Compounds and Biologic Activities: A Review of Cedrela Genus

Chemical Compounds and Biologic Activities: A Review of Cedrela Genus

Evaluation of the bactericidal and trypanocidal activities of triterpenes isolated from the leaves, stems, and flowers of Lychnophora pinaster

Potencial Terapêutico de Espécies Arbóreas em Fragmentos de Floresta Ombrófila Mista

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