Trypanosoma lewisi: Enhanced resistance in naive lactating rats and their suckling pups

Mellow, George H.; Clarkson, Allen B.

doi:10.1016/0014-4894(82)90063-7

Cited by 5 publications

(2 citation statements)

References 12 publications

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“…Although evidence suggests that natural RF may be involved in the clearance of IC, 9 , 10 the precise function of RF and the mechanism(s) regulating its production in vivo is unclear. Kinetic studies have shown that IgM–RF or IgG–RF each interact with aggregated IgG or IC with much greater affinity (˜100‐fold) than with monomeric IgG, indicating that RF binds specifically to IC containing IgG.…”

Section: Introductionmentioning

confidence: 99%

“…4±6 On the other hand, sustained levels of pathological RF are observed in immune complex (IC)-associated autoimmune diseases such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and vasculitis. 4,6±8 Although evidence suggests that natural RF may be involved in the clearance of IC, 9,10 the precise function of RF and the mechanism(s) regulating its production in vivo is unclear. Kinetic studies have shown that IgM±RF or IgG±RF each interact with aggregated IgG or IC with much greater af®nity (y100-fold) than with monomeric IgG, indicating that RF binds speci®cally to IC containing IgG.…”

Section: Introductionmentioning

confidence: 99%

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Histidine‐rich glycoprotein prevents the formation of insoluble immune complexes by rheumatoid factor

1999

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SUMMARYIn previous studies we have shown that histidine-rich glycoprotein (HRG), a relatively abundant plasma protein, can bind to immunoglobulin G (IgG) and inhibit the insolubilization of IgGcontaining immune complexes (IC). It was of interest, therefore, to determine whether HRG can inhibit the formation of insoluble IC (IIC) resulting from the interaction of rheumatoid factor (RF) with human IgG-containing IC. Light scattering techniques were used to examine the effect of HRG on the formation of IIC between RF and IC containing human IgG according to three different models. In all three models physiological concentrations of HRG could block the formation of IIC induced by RF. Optical biosensor studies of the RF±IgG interaction also revealed that HRG can mask the epitopes on IgG recognized by RF. Additional studies examined whether HRG can solubilize already formed IIC and demonstrated that HRG can, in fact, partially solubilized IIC. These data indicate that HRG can regulate the formation of IIC induced by RF at three levels: namely by inhibiting the initial recognition of IgG containing IC by RF, by inhibiting the subsequent insolubilization of IgG containing IC by RF and by solubilizing already formed IIC. Collectively, these ®ndings suggest that HRG may be an important inhibitor of the formation of pathogenic IC in diseases such as systemic lupus erythematosus and rheumatoid arthritis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Histidine‐rich glycoprotein prevents the formation of insoluble immune complexes by rheumatoid factor

1999

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Immune Reactions to Trypanosomes and How They Are Evaded. Ablastin. Antigenic Variation

Trager

1986

Living Together

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Response : Rheumatoid Factors and Chagas' Disease

Clarkson

Mellow

1983

Science

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branch D. limbata biosynthesizes polygodial (1), which constitutes its chemical defense and is stored in the mantle. Thus the ability of a nudibranch to elaborate its chemical defense has been demonstrated. Dendrodoris limbata also synthesizes the mixture of sesquiterpenoid esters (2) found in the digestive glands. We believe that these esters should be regarded as products of further metabolism of polygodial as a result of a detoxication process. Polygodial is a reactive molecule that readily interacts with NH2 groups (16) and therefore could be toxic for D. limbata itself if stored for a long time. When the animal is molested, the compound is secreted through the skin. The esters (2), which are found into the hepatopancreas only, could represent the normal excretory metabolites of polygodial.

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Trypanosoma lewisi: Enhanced resistance in naive lactating rats and their suckling pups

Cited by 5 publications

References 12 publications

Histidine‐rich glycoprotein prevents the formation of insoluble immune complexes by rheumatoid factor

Histidine‐rich glycoprotein prevents the formation of insoluble immune complexes by rheumatoid factor

Immune Reactions to Trypanosomes and How They Are Evaded. Ablastin. Antigenic Variation

Response : Rheumatoid Factors and Chagas' Disease

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