Trypsin‐like activity levels of Treponema denticola and Porphyromonas gingivalis in adults with periodontitis

Pederson, E. D.; Miller, Joshua W.; Matheson, S.; Simonson, Lloyd G.; Chadwick, David E.; Covill, P. J.; Turner, Donald W.; Lamberts, B.L.; Morton, H. E.

doi:10.1111/j.1600-051x.1994.tb01167.x

Cited by 22 publications

(13 citation statements)

References 28 publications

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“…Proteolytic activity, in particular ‘trypsin‐like’ proteolytic activity of subgingival plaque has been positively correlated with clinical parameters of periodontitis (198, 268, 304). The four pathogens discussed in this review that have been highly associated with periodontitis all produce extracellular proteolytic activity including ‘trypsin‐like’ protelytic activity.…”

Section: Discussionmentioning

confidence: 99%

“…Proteolytic activity in subgingival plaque, in particular trypsin‐like proteolytic activity, has been highly correlated with clinical measurements of periodontitis (198, 268, 304). Culture supenatants of A. actinomycetemcomitans Y4 (serotype b) have been shown to have high trypsin‐like proteolytic activity (369).…”

Section: Actinobacillus Actinomycetemcomitans Antigensmentioning

confidence: 99%

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Antigens of bacteria associated with periodontitis

O'Brien-Simpson¹,

Veith²,

Dashper³

et al. 2004

Periodontology 2000

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Section: Discussionmentioning

confidence: 99%

Section: Actinobacillus Actinomycetemcomitans Antigensmentioning

confidence: 99%

Antigens of bacteria associated with periodontitis

O'Brien-Simpson¹,

Veith²,

Dashper³

et al. 2004

Periodontology 2000

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“…There was a close relationship between this peptidase activity and attachment loss within a 12-month period (336). The ability of plaque samples to hydrolyze the fluorescent substrate Z-Gly-Gly-Arg-AFC was significantly correlated with the levels of T. denticola and P. gingivalis in plaque samples, as measured by a quantitative monoclonal antibody assay (223).…”

Section: Enzyme Assaysmentioning

confidence: 95%

Periodontal Disease as a Specific, albeit Chronic, Infection: Diagnosis and Treatment

Loesche

Grossman²

2001

Clin Microbiol Rev

413

338

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Periodontal disease is perhaps the most common chronic infection in adults. Evidence has been accumulating for the past 30 years which indicates that almost all forms of periodontal disease are chronic but specific bacterial infections due to the overgrowth in the dental plaque of a finite number of mostly anaerobic species such as Porphyromonas gingivalis, Bacteroides forsythus, and Treponema denticola. The success of traditional debridement procedures and/or antimicrobial agents in improving periodontal health can be associated with the reduction in levels of these anaerobes in the dental plaque. These findings suggest that patients and clinicians have a choice in the treatment of this overgrowth, either a debridement and surgery approach or a debridement and antimicrobial treatment approach. However, the antimicrobial approach, while supported by a wealth of scientific evidence, goes contrary to centuries of dental teaching that states that periodontal disease results from a “dirty mouth.” If periodontal disease is demonstrated to be a risk factor for cardiovascular disease and stroke, it will be a modifiable risk factor since periodontal disease can be prevented and treated. Since the antimicrobial approach may be as effective as a surgical approach in the restoration and maintenance of a periodontally healthy dentition, this would give a cardiac or stroke patient and his or her physician a choice in the implementation of treatment seeking to improve the patient's periodontal condition so as to reduce and/or delay future cardiovascular events

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“…denticola is almost always found in association with other oral micro-organisms, including recognized periodontal pathogens (Faveri et al, 2009;Söder et al, 1993). T. denticola has been shown to coaggregate with a number of these micro-organisms (Grenier, 1992;Onagawa et al, 1994;Yao et al, 1996;Kolenbrander et al, 1995) and, in particular, there seems to be a strong link between P. gingivalis and T. denticola in subgingival plaque samples (Pederson et al, 1994;Simonson et al, 1992). It has been suggested that the occurrence of T. denticola at a site of periodontitis might in fact depend upon the presence of P. gingivalis .…”

Section: Introductionmentioning

confidence: 99%