Tryptophan capped gold–silver bimetallic nanoclusters-based turn-off fluorescence sensor for the determination of histamine

Metal Nanoclusters in Point-of-Care Sensing and Biosensing Applications

“…The quenching degree of the PL was linked to the concentration of the histamine to use for the analysis of real samples. The method presented a good linearity in the ranges between 85 and 4 μM with a LOD of 0.9 μM …”

“…The method presented a good linearity in the ranges between 85 and 4 μM with a LOD of 0.9 μM. 535 AgNCs have also been explored for doping and alloying with other atoms to tune and improve their signaling, stability, strength, and performance in the point-of-care surfaces. The doping atoms inserted into AgNCs are generally noble metals such as Au, Pt, and Pd, which have comparable atomic diameters to Ag.…”

The roles of templates consisting of amino acids in the synthesis and application of gold nanoclusters

“…65 Trp-AgAuNCs capped by tryptophan allowed determination of histamine based on turn-off fluorescence, which was attributed to the histamine-induced aggregation of Trp-AgAuNCs via electrostatic attraction. 99 Using 3-mercaptopropionic acid (MPA), two AuNCs were synthesized by introducing P1 (CCIHK(Ac)) and P2 (CCLRRASLG), respectively. The histone deacetylase 1 (HDAC 1) and PKA can exert chemical modifications of P1 and P2 on AuNCs, leading to the fluorescence quenching of AuNCs for detection of HDAC 1 and PKA.…”

“…174 For antibacterial AuAgNCs, using 6-mercaptohexanoic acid (MHA) as the ligand, the formed Au x Ag 25−x (MHA) 18 NCs with x from 0 to 25 showed decreased antimicrobial ability, because their enhanced stability led to the decline of ROS. 175 Although AuAgNCs stabilized by the template consisting of amino acids have been synthesized, 47,65,99 there is little research on their antibacterial activity. More antibacterial AuAgNCs stabilized by proteins and peptides need to be developed and investigated.…”

Approaching Tryptophan-Derived Polynorbornene Fluorescent Chemosensors: Synthesis, Characterization, and Sensing Ability for Biomedical Applications as Biomarkers for Detecting Fe2+ Ions

“…Tryptophan (Trp), an amino acid, is known for its intrinsic fluorescence, which is quenched through resonance energy transfer or electron mechanisms upon interaction with ligands, such as metal ions. , This characteristic has driven extensive exploration of Trp in the research field for the design of fluorescent-based chemosensors. − Significant progress has been achieved in synthesizing fluorescent molecular probes and polymer-based fluorescent probes incorporating Trp. For instance, a Trp-based turn-off molecular chemosensor demonstrated selective detection of Fe 2+ , effectively discriminating the ion from tap and drinking water .…”