Tryptophan glycoconjugate as a novel marker of renal function

Takahira, Reiko; Yonemura, Katsuhiko; Yonekawa, Osamu; Iwahara, Kunihiro; Kanno, Takashi; Fujise, Yutaka; Hishida, Akira

doi:10.1016/s0002-9343(00)00693-8

Cited by 53 publications

(33 citation statements)

References 26 publications

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“…22 It has been postulated as a marker of kidney function in individuals with kidney disease. 23 The association between C-mannosyltryptophan and annual eGFR decline even after adjusting for baseline eGFRcr and clinical CKD risk factors may point toward an etiologic role in CKD progression. Alternatively, it may be a more sensitive kidney function marker compared with serum creatinine in early phases of CKD, when GFR is only mildly impaired and serum creatinine is still unchanged.…”

Section: In Light Of the Current Metabolomics Literaturementioning

confidence: 99%

A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population

Sekula

Goek

Quaye

et al. 2016

Journal of the American Society of Nephrology

172

152

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Small molecules are extensively metabolized and cleared by the kidney. Changes in serum metabolite concentrations may result from impaired kidney function and can be used to estimate filtration (e.g., the established marker creatinine) or may precede and potentially contribute to CKD development. Here, we applied a nontargeted metabolomics approach using gas and liquid chromatography coupled to mass spectrometry to quantify 493 small molecules in human serum. The associations of these molecules with GFR estimated on the basis of creatinine (eGFRcr) and cystatin C levels were assessed in #1735 participants in the KORA F4 study, followed by replication in 1164 individuals in the TwinsUK registry. After correction for multiple testing, 54 replicated metabolites significantly associated with eGFRcr, and six of these showed pairwise correlation (r$0.50) with established kidney function measures: C-mannosyltryptophan, pseudouridine, N-acetylalanine, erythronate, myo-inositol, and N-acetylcarnosine. Higher C-mannosyltryptophan, pseudouridine, and O-sulfo-L-tyrosine concentrations associated with incident CKD (eGFRcr ,60 ml/min per 1.73 m 2 ) in the KORA F4 study. In contrast with serum creatinine, C-mannosyltryptophan and pseudouridine concentrations showed little dependence on sex. Furthermore, correlation with measured GFR in 200 participants in the AASK study was 0.78 for both C-mannosyltryptophan and pseudouridine concentration, and highly significant associations of both metabolites with incident ESRD disappeared upon adjustment for measured GFR. Thus, these molecules may be alternative or complementary markers of kidney function. In conclusion, our study provides a comprehensive list of kidney function-associated metabolites and highlights potential novel filtration markers that may help to improve the estimation of GFR. 27: 117527: -118827: , 201627: . doi: 10.1681 Metabolites are small organic molecules involved in both systemic and organ-specific metabolic processes. The kidney receives about 20% of the cardiac output and is one of the most important excretory organs for a wide variety of metabolites, many of which are freely filtered as solutes of small molecular size. In addition, many metabolites are actively secreted into or reabsorbed from the tubular lumen. The kidney also has a role in the generation and metabolism of some metabolites such as amino acids. Changes in blood metabolite J Am Soc Nephrol

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Section: In Light Of the Current Metabolomics Literaturementioning

confidence: 99%

A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population

Sekula

Goek

Quaye

et al. 2016

Journal of the American Society of Nephrology

172

152

View full text Add to dashboard Cite

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“…A novel serum marker of glomerular filtration is 2-(!-mannopyranosyl)-L-tryptophan, which is unlike creatinine, independent of muscle mass and tubular secretion (81). Renal handling resembles that of inulin (81).…”

Section: Tryptophan Glycoconjugatementioning

confidence: 99%

“…Renal handling resembles that of inulin (81). Measurement involves laborious high-performance liquid chromatography.…”

Section: Tryptophan Glycoconjugatementioning

confidence: 99%

Biomarkers of Acute Renal Injury and Renal Failure

Trof

Maggio

Leemreis

et al. 2006

Shock

179

101

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Acute renal failure (ARF) is a frequent problem in the intensive care unit and is associated with a high mortality. Early recognition could help clinical management, but current indices lack sufficient predictive value for ARF. Therefore, there might be a need for biomarkers in detecting renal tubular injury and/or dysfunction at an early stage before a decline in glomerular filtration rate is noted by an increased serum creatinine. A MEDLINE/PubMed search was performed, including all articles about biomarkers for ARF. All publication types, human and animal studies, or subsets were searched in English language. An extraction of relevant articles was made for the purpose of this narrative review. These biomarkers include tubular enzymes (alpha- and pi-glutathione S-transferase, N-acetyl-glucosaminidase, alkaline phosphatase, gamma-glutamyl transpeptidase, Ala-(Leu-Gly)-aminopeptidase, and fructose-1,6-biphosphatase), low-molecular weight urinary proteins (alpha1- and beta2-microglobulin, retinol-binding protein, adenosine deaminase-binding protein, and cystatin C), Na+/H+ exchanger, neutrophil gelatinase-associated lipocalin, cysteine-rich protein 61, kidney injury molecule 1, urinary interleukins/adhesion molecules, and markers of glomerular filtration such as proatrial natriuretic peptide (1-98) and cystatin C. These biomarkers, detected in urine or serum shortly after tubular injury, have been suggested to contribute to prediction of ARF and need for renal replacement therapy. However, excretion of these biomarkers may also increase after reversible and mild dysfunction and may not necessarily be associated with persistent or irreversible damage. Large prospective studies in human are needed to demonstrate an improved outcome of biomarker-driven management of the patient at risk for ARF.

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“…The inulin is neither secreted nor reabsorbed by the kidneys, consisting, thus, a freely filtered substance. It is considered the 'gold standard' for measuring the glomerular filtration (Feher, 2012;Takahira et al, 2001;Padrini & Palatini, 2003).…”

Section: Resultsmentioning

confidence: 99%

<b>The role of pneumoperitoneum in the glomerular filtration in an experimental model with 2/3 reduction of the renal mass

Valadão¹,

Fagundes²,

Cavazana³

et al. 2017

Acta Sci. Health Sci.

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ABSTRACT. Objective: To evaluate the influence of the CO 2 pneumoperitoneum in the glomerular filtration in a rat model with a 2/3 reduction of renal parenchyma. Methods: Adult Wistar male rats (n = 50) were subjected to right nephrectomy and a 2/3 ligature of the renal left vascular branch. Animals were randomly distributed as follows: GI (n = 10) -simulated, GII (n = 20) -8 mm Hg pneumoperitoneum, and GIII (n = 20) -15 mm Hg pneumoperitoneum. After two (GIIA and GIIIA) and three (GIIB and GIIIB) hours of insufflation, and one hour of disinsufflation, they were evaluated for the following aspects: mean blood pressure (MBP), microhematocrit, urinary volume and inulin clearance. Results: The microscopic aspects showed signs of glomerulosclerosis that caused proteinuria. Renal function with 8 mm Hg pneumoperitoneum after two hours of disinsufflation (Δ% = 202.68) was better than after three hours (Δ% = 10.89). With 15 mm Hg pneumoperitoneum, the renal function was damaged by both procedures, that is, two (Δ% = -3.57) and three hours (Δ% = -3.25). Conclusion: Inulin clearance evidenced renal insufficiency in the model with a 2/3 reduction of renal mass, and depending on both the increase of the exposure time and the pressure intensity, it can be more intensified.Keywords: inulin, kidney failure, pneumoperitoneum, video-assisted surgery.O papel do pneumoperitônio na função renal em um modelo experimental de redução de 2/3 do parênquima renal RESUMO. Este estudo tem como objetivo avaliar a influência do pneumoperitônio induzido CO 2 sobre a função renal em um modelo em ratos com redução de 2/3 de sua massa renal. Em relação à metodologia, ratos Wistar (n=50), machos, adultos, foram submetidos à nefrectomia direita e ligadura de 2/3 do pedículo vascular renal esquerdo. A seguir, foram aleatoriamente distribuídos em GI (n=10)-Simulado, GII (n=20) com pneumoperitônio de 8 mmHg e GIII (n=20) compneumoperitônio de 15 mmHg, por uma hora. Após duas (GIIA e GIIIA) e três (GIIB e GIIIB) horas da desinsuflação, foram avaliadas a pressão arterial média (PAM), micro-hematócrito, volume urinário e clearance da inulina. Os resultados da microscopia mostraram que o rim remanescente apresentou sinais de glomeruloesclerose, caracterizada pela proteinúria. A função renal com pneumoperitônio de 8 mmHg após duas horas da insuflação (Δ%=202,68) foi melhor do que com três horas (Δ%= 10,89). Com o pneumoperitônio de 15 mmHg tanto com duas (Δ%=-3,57) quanto três horas (Δ%=-3,25), a função renal esteve prejudicada. Concluiu-se que oclearance da inulina mostrou haver um comprometimento da função renal no modelo de redução de 2/3 do parênquima e que, dependendo do volume e do tempo de pneumoperitônio, pode ser agravada.Palavras-chave: inulina, insuficiência renal, pneumoperitônio, cirurgia vídeo-assistida.

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Tryptophan glycoconjugate as a novel marker of renal function

Cited by 53 publications

References 26 publications

A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population

A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population

Biomarkers of Acute Renal Injury and Renal Failure

<b>The role of pneumoperitoneum in the glomerular filtration in an experimental model with 2/3 reduction of the renal mass

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