Tryptophan hydroxylase-2 polymorphism is associated with white matter integrity in first-episode, medication-naïve major depressive disorder patients

Ping, Liangliang; Xu, Jian; Zhou, Cong; Lü, Jin; Lü, Yi; Shen, Zonglin; Jiang, Linling; Dai, Nan; Xu, Xiufeng; Cheng, Yuqi

doi:10.1016/j.pscychresns.2019.02.002

Cited by 9 publications

(6 citation statements)

References 46 publications

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“…A study of untreated patients with MDD showed damage to the brain white matter fiber bundles in the emotional control circuit. And it was associated with the TPH2-rs4570625 GG polymorphism ( 32 ). Furthermore, the serotonin transporter is involved in neuronal serotonin reuptake, which is the primary target of selective serotonin reuptake inhibitors.…”

Section: Possible Pathogenesis Of White Matter Changes Caused By Mddmentioning

confidence: 99%

“…Working memory and attention persistence are associated with the anterior cingulate cortex ( 50 ). The superior longitudinal fasciculus, inferior longitudinal fasciculus, fronto-occipital fasciculus, and posterior thalamic radiation have all been reported to have decreased FA of white matter ( 32 , 51 ). As mentioned previously, the findings of several studies are inconsistent.…”

Section: White Matter Alterations In Mddmentioning

confidence: 99%

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White Matter Alterations in Depressive Disorder

Liu

Gong

et al. 2022

Front. Immunol.

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Depressive disorder is the most prevalent affective disorder today. Depressive disorder has been linked to changes in the white matter. White matter changes in depressive disorder could be a result of impaired cerebral blood flow (CBF) and CBF self-regulation, impaired blood-brain barrier function, inflammatory factors, genes and environmental factors. Additionally, white matter changes in patients with depression are associated with clinical variables such as differential diagnosis, severity, treatment effect, and efficacy assessment. This review discusses the characteristics, possible mechanisms, clinical relevance, and potential treatment of white matter alterations caused by depressive disorders.

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Section: Possible Pathogenesis Of White Matter Changes Caused By Mddmentioning

confidence: 99%

Section: White Matter Alterations In Mddmentioning

confidence: 99%

White Matter Alterations in Depressive Disorder

Liu

Gong

et al. 2022

Front. Immunol.

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“…The −703 G/ T polymorphism of the TPH2 gene (rs4570625) has been associated with amygdalar responsiveness (Brown et al, 2005;Canli et al, 2005), risk of affective disorder (Gao et al, 2012), and with behavioural inhibition (Latsko et al, 2016). This genotype is associated with functional connectivity (Tao et al, 2018) and white matter integrity (Ping et al, 2019) in the brain. A recent systematic review and meta-analysis concluded that the TPH2 rs4570625 polymorphism is significantly associated with psychiatric disorders such as unipolar depression, bipolar disorder, schizophrenia, and suicide (Ottenhof et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Reward sensitivity, affective neuroscience personality, symptoms of attention-deficit/hyperactivity disorder, andTPH2-703G/T (rs4570625) genotype

Pulver

Kiive

Harro

2020

Acta Neuropsychiatr.

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Objective: Reward sensitivity is an increasingly used construct in psychiatry, yet its possible inner structure and relationship with other affective variables are not well known. Methods: A reward sensitivity measurement scale was constructed on the basis of large item pool collected from birth cohort representative samples (the Estonian Children Personality Behaviour and Health Study; original n = 1238). Affective Neuroscience Personality Scale (ANPS) and the Adult Attention deficit hyperactivity disorder (ADHD) Self-Report Scale (ASRS) were administered in young adulthood. A variant (rs4570625) of the gene encoding tryptophan hydroxylase 2 (TPH2) that is responsible for the synthesis of central serotonin was genotyped. Results: Reward sensitivity consisted of two orthogonal components, operationally defined as Openness to Rewards and Insatiability by Reward, that respectively characterise the striving towards multiple rewards and the strong pursuit and fixation to a particular reward. While SEEKING and PLAY (and to lower extent CARE) of the ANPS co-varied with Openness to Rewards, FEAR, SADNESS, and ANGER were related to Insatiability by Reward. The total score of ASRS was moderately correlated with Insatiability by Reward, while the association with Openness to Rewards was negligible. However, ASRS Inattention had some negative relationship with the Social Experience facet of Openness to Rewards. The T/T homozygotes for the TPH2 promoter polymorphism had lower Insatiability by Reward but not Openness to Rewards. Conclusions: Behaviours sensitive to rewards are separable to the components of variability and fixation, and these components are differentially related to affective aspects of personality, attention, and hyperactivity as well as to TPH2 genotype.

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“…It is known that there are biological factors (such as tryptophan-a building block of serotonin-depletion) which strongly influence the appearance of depressive disorders [45]. Tryptophan hydroxylase-2 (TPH-2) gene may play an important role in maintaining the normal level of serotonin in the central nervous system [46,47], and, as suggested by Ping et al (2019) [17], neurotransmission by serotonin in the brain may be associated with changes in white matter integrity in patients with major depressive disorder. On the other hand, we know that tryptophan intake is inversely associated with the level of self-reported depression [41] and also affects the inflammatory system [42].…”

Section: Discussionmentioning

confidence: 99%

“…Hormonal and neurotransmission responses in FM patients showed that low serotonin levels are involved in FM. Regarding biochemical mediators, the proper intake of tryptophan (TRY), an essential amino acid precursor of serotonin [1] and one of the major contributors to the catabolic process [12], through food in a suitable diet, could improve and remit most FM symptoms (depressive disorders, mood state, pain, fatigue, and sleep disorders) [9,10,[14][15][16][17][18]. Although it has not been demonstrated in humans yet, TRY supplementation also diminished hyperalgesia and reduced serum cortisol concentrations in rats [19].…”

Section: Introductionmentioning

confidence: 99%

Psychological and Sleep Effects of Tryptophan and Magnesium-Enriched Mediterranean Diet in Women with Fibromyalgia

Martínez-Rodríguez

Rubio-Arias

Ramos-Campo

et al. 2020

IJERPH

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Anxiety, mood disturbance, eating and sleep disorders, and dissatisfaction with body image are prevalent disorders in women with fibromyalgia. The authors of this study aimed to determine the effects of tryptophan (TRY) and magnesium-enriched (MG) Mediterranean diet on psychological variables (trait anxiety, mood state, eating disorders, self-image perception) and sleep quality in women with fibromyalgia (n = 22; 49 ± 5 years old). In this randomized, controlled trial, the participants were randomly assigned to the experimental group and the placebo group. The intervention group received a Mediterranean diet enriched with high doses of TRY and MG (60 mg of TRY and 60 mg of MG), whereas the control group received the standard Mediterranean diet. Pittsburgh Sleep Quality Questionnaire, Body Shape Questionnaire, State–Trait Anxiety Inventory (STAI), Profile of Mood States (POMS-29) Questionnaire, Eating Attitudes Test-26, and Trait Anxiety Inventory were completed before and 16 weeks after the intervention. Significant differences were observed between groups after the intervention for the mean scores of trait anxiety (p = 0.001), self-image perception (p = 0.029), mood disturbance (p = 0.001), and eating disorders (p = 0.006). This study concludes that tryptophan and magnesium-enriched Mediterranean diet reduced anxiety symptoms, mood disturbance, eating disorders, and dissatisfaction with body image but did not improve sleep quality in women with fibromyalgia.

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Tryptophan hydroxylase-2 polymorphism is associated with white matter integrity in first-episode, medication-naïve major depressive disorder patients

Cited by 9 publications

References 46 publications

White Matter Alterations in Depressive Disorder

White Matter Alterations in Depressive Disorder

Reward sensitivity, affective neuroscience personality, symptoms of attention-deficit/hyperactivity disorder, andTPH2-703G/T (rs4570625) genotype

Psychological and Sleep Effects of Tryptophan and Magnesium-Enriched Mediterranean Diet in Women with Fibromyalgia

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