Tryptophan hydroxylase and serotonin receptor 1A expression in the retina of the sea lamprey

Cornide‐Petronio, María Eugenia; Anadón, Ramón; Barreiro‐Iglesias, Antón; Rodicio, Marı́a Celina

doi:10.1016/j.exer.2015.04.017

Cited by 10 publications

(9 citation statements)

References 54 publications

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“…These data support the idea that the 5-HT synthesis is more widely distributed in lower vertebrate retinas than previously supposed. We believe that the serotonin retinal source is not single, which is in agreement with the recent genetic studies on the tryptophan hydroxylase mRNA expression in the retina [8,9].…”

Section: Serotoninergic Systemsupporting

confidence: 91%

“…The same is true for some horizontal and single ganglion cells. It seems that serotonin retinal sources are more abundant than was previously believed which is in agreement with the results from recent genetic studies on the tryptophan hydroxylase mRNA expression in both distal and proximal retinal layers [8,9]. The actions of serotonin are mediated by numerous serotonin receptors subdivided into 7 large families -from 5-HT1 to 5-HT7 [for review see 10].…”

Section: Introductionsupporting

confidence: 82%

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Interactions between the Serotoninergic System and the Ionotropic GABA Receptors in Frog and Turtle Retina: An Immunofluorescent Study

Liliya¹

2018

JAMB

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The aim of the present study was to elucidate the putative interactions between the serotoninergic and the GABAergic systems in the lower vertebrate retinas. Experiments were performed on 12-14 µm frozen frog and turtle retinal sections, processed with more than 10 different antibodies directed against serotonin, GABA and their membrane receptors by means of the indirect immunocytochemical method. The results showed that some of the GABAergic retinal neurons possess the serotonin receptors 5-HT2A and 5-HT3A on their cell membrane, and vice versa: certain serotoninergic neurons possess the ionotropic GABA A and GABA C receptors. A simple neuronal chart is proposed to explain how the activation of serotonin receptors on a subgroup of GABAergic amacrine cells can decrease the GABA C receptor mediated inhibition on the retinal bipolar cells, the main generators of ERG. As the retina is a natural biological model of CNS, the relationships between both neurotransmitter systems described here may elucidate their participation in certain brain functions and to explain the possible mechanisms of action of some antidepressant drugs.

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Section: Serotoninergic Systemsupporting

confidence: 91%

Section: Introductionsupporting

confidence: 82%

Interactions between the Serotoninergic System and the Ionotropic GABA Receptors in Frog and Turtle Retina: An Immunofluorescent Study

Liliya¹

2018

JAMB

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“…Both serotonin and melatonin levels here undergo diurnal rhythmic changes, as has been shown by many authors [7,53,55]. In addition to photoreceptors level, the TrypH1 mRNA is proved to exist in the vitreal portion of the inner nuclear layer as well, and to a lesser extent in the ganglion cells layer [50,52,53]. These facts are in conjunction with our observations about the presence of TrypHimmunoreactive bipolar cells, as well as with the presence of single TrypH-immunoreactive horizontal and ganglion cells (Fig.…”

Section: Serotoninergic Neuronsmentioning

confidence: 57%

“…It was definitely shown by RT-PCR that TrypH 1(TPH1), the "classical" TrypH mRNA is the prevalent form present in the retina [50]. TrypH 1 is demonstrated in the retinas of different species: rat [50], sea lamprey [51,52], chicken [53] and Xenopus [55]. In all types of retinas studied [50 -54], the TrypH1 mRNA is most abundant in the photoreceptors, which is in conjunction with the strong labeling of photoreceptors by the anti-TrypH antibody, observed in our experiments (Fig.…”

Section: Serotoninergic Neuronsmentioning

confidence: 99%

Tryptophan Hydroxylase and Serotonin Receptors 5-HT1A, 5-HT2A, 5-HT3A, 5-HT4, 5-HT5A, 5-HT6 and 5-HT7 in Frog and Turtle Retina: an Immunofluorescence Study

Liliya¹,

Desislava²,

Kupenova³

2017

JAMB

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Abstract. Serotonin (5-HT) is one of the major monoamines in the brain. It is also found in the retina, a part of the brain, where a subgroup of amacrine cells are considered to be the sole retinal source of 5-HT. The data, obtained so far, about the serotonin receptors' function are contradictory. Therefore, our aim was to study the distribution of the 5-HT synthesizing neurons and the serotonin receptors from 5-HT1A to 5-HT7 in frog and turtle retinas, using the indirect immunofluorescent method. We found strong Tryptophan hydroxylase immunoreactivity in many amacrine and bipolar cells. Some horizontal, ganglion and glial cells were also stained, as well as a bundle of parallel axons in the proximal retina. All 5-HT receptors were also very well expressed. Our data show that the serotonin retinal sources are more numerous than was previously thought. The great variety of receptors expressed implies that serotonin may fulfill different functions, serving both as neuro-and glio-transmitter/modulator.

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“…19 The first step is catalyzed by tryptophan hydroxylase (TPH) and synthesizes 5-hydroxytryptophan (5-HT). 20,21 Next, the aromatic amino acid decarboxylase (AAAD) synthesizes serotonin. 22 At this point, the melatonin synthesis pathway divides.…”

Section: Melatonin Synthesis and Metabolismmentioning

confidence: 99%

<p>Role of Melatonin in the Regulation of Pain</p>

Xie

Fan

et al. 2020

JPR

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Melatonin is a pleiotropic hormone synthesized and secreted mainly by the pineal gland in vertebrates. Melatonin is an endogenous regulator of circadian and seasonal rhythms. Melatonin is involved in many physiological and pathophysiological processes demonstrating antioxidant, antineoplastic, anti-inflammatory, and immunomodulatory properties. Accumulating evidence has revealed that melatonin plays an important role in pain modulation through multiple mechanisms. In this review, we examine recent evidence for melatonin on pain regulation in various animal models and patients with pain syndromes, and the potential cellular mechanisms.

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Tryptophan hydroxylase and serotonin receptor 1A expression in the retina of the sea lamprey

Cited by 10 publications

References 54 publications

Interactions between the Serotoninergic System and the Ionotropic GABA Receptors in Frog and Turtle Retina: An Immunofluorescent Study

Interactions between the Serotoninergic System and the Ionotropic GABA Receptors in Frog and Turtle Retina: An Immunofluorescent Study

Tryptophan Hydroxylase and Serotonin Receptors 5-HT1A, 5-HT2A, 5-HT3A, 5-HT4, 5-HT5A, 5-HT6 and 5-HT7 in Frog and Turtle Retina: an Immunofluorescence Study

<p>Role of Melatonin in the Regulation of Pain</p>

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