TSA-catalyzed regioselective synthesis of medicinally important 4-aryl-substituted dihydropyrimidine derivatives fused to pyrazole and triazole scaffolds via an efficient and green Domino reaction

Tungstic acid-functionalized Fe3O4@TiO2: preparation, characterization and its application for the synthesis of pyrano[2,3-c]pyrazole derivatives as a reusable magnetic nanocatalyst

“…24 They are also the main building blocks in the synthesis of natural products as well as in heterocyclic compounds. 25 Taking the above facts into consideration and in continuation of our research on the synthesis of heterogeneous catalysts, [26][27][28][29][30][31] in this study, we have immobilized tungstic acid on TiO 2 -coated Fe 3 O 4 magnetic nanoparticles (Fe 3 O 4 @TiO 2 @(-CH 2 ) 3 OWO 3 H) and then investigated its performance as a novel strong, recoverable, and stable acid nanocatalyst for synthesis of pyrano[2,3-c]pyrazole derivatives.…”

Different Synthetic Methods for the Preparation of Triazolopyrimidines and their Biological Profile

“…Farahi et al [78] developed a newly regioselective domino reaction by the use of tungstate sulfuric acid (TSA) as a Brønsted acid recyclable catalyst for the synthesis of a new In other scientific work, Jamasbi et al [79] presented an efficient method for the synthesis of Haghighat et al [80] reported the synthesis of [1,2,4]triazolopyrimidine/quinazolinone derivatives 108 (85-90 %), 109 (89-90 %), and 110 (85-96 %) as important biologically active compounds under solvent-free condition in the presence of γ-Fe 2 O 3 @Ph-PMO-NaHSO 4 as a catalyst (Scheme 70). The major advantages of this protocol are numerous: respect of the environment, high yields, short reaction times, reusability of the catalyst and easy and fast isolation of the products.…”

“…Farahi et al [78] . developed a newly regioselective domino reaction by the use of tungstate sulfuric acid (TSA) as a Brønsted acid recyclable catalyst for the synthesis of a new series of tiazolopyrimidine derivatives 106 (87–91 %) content pyrazole nucleus in solvent‐free (Scheme 68).…”

Synthesis and Evaluation of the Antiproliferative Potency and Induced Biochemical Parameters of Novel Pyrazolones Derivatives Towards Hepatocellular Carcinoma

“…The chemistry of pyrazolones and related compounds is particularly interesting because of their potential application in medicinal chemistry, as they have constituents of several intermediates for medicinal drugs [1]. Compounds with a pyrazoline structure have been found to possess anti-fungal [2], anti-depressant [3], anticonvulsant [4], anti-inflammatory [5],antibacterial [6][7], antipyretic [8] and antitumor [9][10] properties. Cancer is one of the most widespread serious diseases.…”