TSPAN1, a novel tetraspanin member highly involved in carcinogenesis and chemoresistance

García-Mayea, Yoelsis; Mir, Cristina; Carballo, Laia; Sánchez-García, Almudena; Bataller, Marina; Lleonart, Matilde E.

doi:10.1016/j.bbcan.2021.188674

Cited by 13 publications

(20 citation statements)

References 131 publications

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“…Survival analysis revealed a worse outcome in the high TSPAN1 expression group in PAAD ( Figure 2 A). And TSPAN1 was positively correlated with the sensitivity of AZD-9291 (p < 0.001) The role of TSPAN1 in tumors has been mainly summarized as related to proliferation, metastasis, apoptosis, and autophagy ( Garcia-Mayea et al., 2021 ). Also, TSPAN1 has been reported to increase treatment resistance and act as a prognostic factor in tumors ( Garcia-Mayea et al., 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…And TSPAN1 was positively correlated with the sensitivity of AZD-9291 (p < 0.001) The role of TSPAN1 in tumors has been mainly summarized as related to proliferation, metastasis, apoptosis, and autophagy ( Garcia-Mayea et al., 2021 ). Also, TSPAN1 has been reported to increase treatment resistance and act as a prognostic factor in tumors ( Garcia-Mayea et al., 2021 ). Among the pan-cancer studies, there are more studies related to pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

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The role of tetraspanins pan-cancer

Huang

Sun²,

Lin³

et al. 2022

iScience

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The role of tetraspanins pan-cancer

Huang

Sun²,

Lin³

et al. 2022

iScience

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“…TSPAN1 encodes tetraspanin1, a member of the tetraspanin family, and its upregulation has been viewed to promote carcinogenesis and chemoresistance [ 22 ]. A constant increase of TSPAN1 abundance was regarded as an early event in high-risk endometriosis progression to OC [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

lncRNA DARS-AS1 Modulates TSPAN1-Mediated ITGA2 Hypomethylation by Interaction with miR-194-5p Thus Promoting Ovarian Cancer Progression

Jun

Gao

Chen

et al. 2022

Stem Cells International

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Objective. Ovarian cancer (OC) is usually called the “silent killer” due to its asymptomatic characteristics until advanced stages, thus being a significant threat to female health worldwide. In this work, we characterized an oncogenic DARS-AS1 role in OC. Methods. The aggressiveness behaviors of the OC cell model were examined by CCK-8 assay, transwell invasion assay, flow cytometry, and immunoblotting analysis of apoptosis-related proteins. Interactions of miR-194-5p with lncRNA DARS-AS1 or TSPAN1 and of TSPAN1 with ITGA2 were validated by using a luciferase activity assay and chromatin immunoprecipitation (ChIP) assay. Results. The OC cell model exhibited overexpressed lncRNA DARS-AS1 compared to normal cells. lncRNA DARS-AS1 knockdown led to reduced OC cell growth and metastasis while inducing the apoptosis in the OC cell model. lncRNA DARS-AS1 positively regulated TSPAN1 expression by binding with miR-194-5p and TSPAN1-mediated ITGA2 hypomethylation in OC cells. Further rescue function studies demonstrated that lncRNA DARS-AS1 affected OC cell viability, migration, invasion, and apoptosis ability by modulating miR-194-5p and TSPAN1 expressions. Conclusion. Our work demonstrates that lncRNA DARS-AS1 promotes OC progression by modulating TSPAN1 and ITGA2 hypomethylation by binding with miR-194-5p.

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“…The authors concluded that this gene is related to osteoarthritis, which is a risk factor in dairy cattle. TSPAN1 is involved in cell proliferation, invasion, and survival [ 75 ]. The AJM1 gene is predicted to be involved in cell/cell junction organization [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

Differentially CTCF-Binding Sites in Cattle Rumen Tissue during Weaning

Boschiero

Gao

Baldwin

et al. 2022

IJMS

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The weaning transition in calves is characterized by major structural changes such as an increase in the rumen capacity and surface area due to diet changes. Studies evaluating rumen development in calves are vital to identify genetic mechanisms affected by weaning. This study aimed to provide a genome-wide characterization of CTCF-binding sites and differentially CTCF-binding sites (DCBS) in rumen tissue during the weaning transition of four Holstein calves to uncover regulatory elements in rumen epithelial tissue using ChIP-seq. Our study generated 67,280 CTCF peaks for the before weaning (BW) and 39,891 for after weaning (AW). Then, 7401 DCBS were identified for the AW vs. BW comparison representing 0.15% of the cattle genome, comprising ~54% of induced DCBS and ~46% of repressed DCBS. Most of the induced and repressed DCBS were in distal intergenic regions, showing a potential role as insulators. Gene ontology enrichment revealed many shared GO terms for the induced and the repressed DCBS, mainly related to cellular migration, proliferation, growth, differentiation, cellular adhesion, digestive tract morphogenesis, and response to TGFβ. In addition, shared KEGG pathways were obtained for adherens junction and focal adhesion. Interestingly, other relevant KEGG pathways were observed for the induced DCBS like gastric acid secretion, salivary secretion, bacterial invasion of epithelial cells, apelin signaling, and mucin-type O-glycan biosynthesis. IPA analysis further revealed pathways with potential roles in rumen development during weaning, including TGFβ, Integrin-linked kinase, and Integrin signaling. When DCBS were further integrated with RNA-seq data, 36 putative target genes were identified for the repressed DCBS, including KRT84, COL9A2, MATN3, TSPAN1, and AJM1. This study successfully identified DCBS in cattle rumen tissue after weaning on a genome-wide scale and revealed several candidate target genes that may have a role in rumen development, such as TGFβ, integrins, keratins, and SMADs. The information generated in this preliminary study provides new insights into bovine genome regulation and chromatin landscape.

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TSPAN1, a novel tetraspanin member highly involved in carcinogenesis and chemoresistance

Cited by 13 publications

References 131 publications

The role of tetraspanins pan-cancer

The role of tetraspanins pan-cancer

lncRNA DARS-AS1 Modulates TSPAN1-Mediated ITGA2 Hypomethylation by Interaction with miR-194-5p Thus Promoting Ovarian Cancer Progression

Differentially CTCF-Binding Sites in Cattle Rumen Tissue during Weaning

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