TT virus infection in patients with chronic hepatitis B or C: Influence on clinical, histological and virological features

Kao, Jia‐Horng; Chen, Wendy; Chen, Pei‐Jer; Lai, Ming‐Yang; Chen, Ding‐Shinn

doi:10.1002/(sici)1096-9071(200004)60:4<387::aid-jmv4>3.0.co;2-z

Cited by 30 publications

(30 citation statements)

References 28 publications

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“…The prevalence of TTV positivity in uremic patients has been found in different studies to range between 29.5% and 61%, which is much higher than the reported TTV prevalence among the normal population (1-12%) (16,18,20). Recently, Ikeuchi et al (21) investigated the frequency of superinfection with TTV and HCV (which is known to be endemic among hemodialysis patients), and reported no deleterious effect of TTV on HCV-induced chronic liver disease.…”

Section: Discussionmentioning

confidence: 76%

“…In subsequent studies, it was shown that the virus did not have an important pathogenicity in TTV-positive healthy cases and in different subgroups. Concomitant infection with TTV and either hepatitis B virus (HBV) or HCV is common (18). However, the effect of TTV infection in cases of chronic hepatitis B or C infection is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…However, the effect of TTV infection in cases of chronic hepatitis B or C infection is unknown. Kao et al (18) reported that co-infection with TTV did not affect the clinocopathological course of chronic hepatitis B or C or the response to interferon alpha therapy. Gallian et al (19) reported that the prevalence of TTV infection was higher in patients originating from Africa, patients with previous blood transfusion or organ transplantation, patients with antibody to hepatitis core antigen and those with diabetes mellitus.…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Transfusion Transmitted Virus Infection and its Effect on Renal Graft Survival in Renal Transplant Recipients

Usta

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Ersoy

et al. 2002

Scandinavian Journal of Urology and Nephrology

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Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prevalence of Transfusion Transmitted Virus Infection and its Effect on Renal Graft Survival in Renal Transplant Recipients

Usta

Dilek

Ersoy

et al. 2002

Scandinavian Journal of Urology and Nephrology

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“…TTV infection may be acquired during hemodialysis procedure or by nosocomial transmission. [6,19] However, a non-parenteral route of viral transmission, such as fecal-oral exposure [3] or maternal transmission, [4] has been suggested. TTV genome fragments have been detected in both sera and stool.…”

Section: Discussionmentioning

confidence: 99%

TT Virus Infection in Patients on Peritoneal Dialysis in Taiwan

Hsu

Wang

et al. 2007

Renal Failure

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Many studies have reported the prevalence of transfusion-transmitted virus (TTV) infection in hemodialysis patients, but few reports studied the prevalence of TTV infection in peritoneal dialysis patients. In this study, we determined the prevalence of TTV in a peritoneal dialysis population in Taiwan and related its prevalence with history of blood transfusion, serum hepatitis B surface antigen (HBsAg), antibody to hepatitis C virus (anti-HCV), and serum aminotransferases (AST and ALT) levels. Serum samples from 47 peritoneal dialysis patients and a control group of 43 patients at health examination were studied for TTV viremia by using polymerase chain reaction. The rate of blood transfusion exposure (p < 0.0001), female gender (p = 0.001), younger age (p=0.0014), and serum AST level (p=0.012) were significantly higher in peritoneal dialysis patients. The prevalence of TTV viremia was not significantly different between peritoneal dialysis patients and the control group (23.4% vs. 37.2%). TTV infection was not associated with evident liver diseases in peritoneal dialysis patients, and the infection rate was not different between automated peritoneal dialysis (APD) and continuous ambulatory peritoneal dialysis (CAPD) patients. There was no statistically significant association between TTV infection and age, gender, transfusion history, duration of peritoneal dialysis, AST level, ALT level, HBsAg, or anti-HCV seropositivity in peritoneal dialysis patients. Our results suggest that TTV infection is not associated with evident liver diseases, and there is no difference between TTV infection in healthy individuals and peritoneal dialysis patients. TTV transmission probably occurs via routes unrelated to peritoneal dialysis.

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“…Serum was assayed for HCV RNA by reverse transcription-PCR with primers from the most conserved 5Ј untranslated region of the viral genome, and identification of the HCV genotype was done with type-specific primers as described previously (9). To avoid false-positive results, the methods described by Kwok and Higuchi (11) to prevent cross contamination were applied.…”

Section: Methodsmentioning

confidence: 99%

Occult Hepatitis B Virus Infection and Clinical Outcomes of Patients with Chronic Hepatitis C

et al. 2002

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Although occult hepatitis B virus (HBV) infections in individuals without detectable hepatitis B surfaceantigen (HBsAg) may occur and have been reported to be common in patients with chronic hepatitis C, the clinical relevance remains controversial. We searched for serum HBV DNA in 210 HBsAg-negative patients with hepatitis C virus (HCV)-related liver disease (110 patients with chronic hepatitis, 50 patients with cirrhosis, and 50 patients with hepatocellular carcinoma) by PCR. Most of the patients had detectable antibodies to HBsAg or HBV core antigen. All of the 110 chronic hepatitis C patients were treated with a combination therapy consisting of interferon plus ribavirin. In addition, 100 HBsAg-negative healthy adults served as controls. Thirty-one of the 210 patients (14.8%) had HBV DNA in their sera, as did 15 of the 100 healthy controls (15%). HBV DNA was not detected in the sera of those negative for serological markers of HBV infection. In patients with chronic HCV infection, the prevalence of occult HBV infection did not parallel the severity of liver disease (14.5% in patients with chronic hepatitis, 8% in patients with liver cirrhosis, and 22% in patients with hepatocellular carcinoma). In addition, the sustained response to combination therapy against hepatitis C was comparable between patients with and without occult HBV infection (38 versus 39%). In conclusion, these data suggest that occult HBV infection does not have clinical significance in chronic hepatitis C patients residing in areas where HBV infection is endemic.Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections account for a substantial proportion of cases of chronic liver disease including chronic hepatitis, cirrhosis, and liver cancer. It is estimated that there are 350 million HBV carriers and 170 million HCV carriers worldwide (6). HBV and HCV are transmitted parenterally and share common routes of infection; thus, infection with both viruses may occur, particularly in areas where the two viruses are endemic and among people at high risk for parenteral infections (4, 15). The diagnosis of HBV infection is usually based on the detection of hepatitis B surface antigen (HBsAg), and the disappearance of this antigen indicates the clearance of HBV (6). However, previous studies have shown that HBV DNA can be detected in patients with chronic liver disease who are negative for HBsAg but positive for antibodies to hepatitis B core antigen (anti-HBc) (1, 12, 21). More recently, this so-called occult HBV infection has frequently been identified in patients with chronic HCV infection (5,10,19), and in such patients this occult infection may be associated with more severe liver damage and even the development of hepatocellular carcinoma (HCC) (3,18,20). In addition, several studies have suggested that occult HBV infection may correlate with a lack of response to interferon treatment in patients with chronic hepatitis C (3, 5, 22). Taken together, a low-level HBV infection not only may contribute to the severity of HCV-related liver d...

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TT virus infection in patients with chronic hepatitis B or C: Influence on clinical, histological and virological features

Cited by 30 publications

References 28 publications

Prevalence of Transfusion Transmitted Virus Infection and its Effect on Renal Graft Survival in Renal Transplant Recipients

Prevalence of Transfusion Transmitted Virus Infection and its Effect on Renal Graft Survival in Renal Transplant Recipients

TT Virus Infection in Patients on Peritoneal Dialysis in Taiwan

Occult Hepatitis B Virus Infection and Clinical Outcomes of Patients with Chronic Hepatitis C

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