Tu1797 The Adoptive Transfer of Anxiety and Gut Dysfunction From IBS Patients to Axenic Mice Through Microbiota Transplantation

Palma, Giada De; Lynch, Michael; Lü, Jun; Deng, Yikang; Jury, Jennifer; Umeh, Genevieve; McLean, Peter D.; Bergonzelli, Gabriela; Verdú, Elena F.; Surette, Michael G.; Neufeld, Josh D.; Collins, Stephen M.; Bercik, Premysl

doi:10.1016/s0016-5085(14)63073-0

Cited by 9 publications

(5 citation statements)

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“…Given the provided evidence, the dysbiosis of microbiota in IBS has been acknowledged by the Rome Foundation Working Team 57 as a plausible contributing factor to the disorder. Experiments with animal models have shown that colonization of germ-free animals with microbiota from patients with IBS can induce visceral hypersensitivity 58 , impair intestinal permeability and alter gastrointestinal transit time 59 — indicating the importance and the possible aetiological role of the microbiota in IBS.…”

Section: Mechanisms/pathophysiologymentioning

confidence: 99%

Irritable bowel syndrome

Enck¹,

Aziz

Barbara

et al. 2016

Nat Rev Dis Primers

784

774

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Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high population prevalence. The disorder can be debilitating in some patients, whereas others may have mild or moderate symptoms. The most important single risk factors are female sex, younger age and preceding gastrointestinal infections. Clinical symptoms of IBS include abdominal pain or discomfort, stool irregularities and bloating, as well as other somatic, visceral and psychiatric comorbidities. Currently, the diagnosis of IBS is based on symptoms and the exclusion of other organic diseases, and therapy includes drug treatment of the predominant symptoms, nutrition and psychotherapy. Although the underlying pathogenesis is far from understood, aetiological factors include increased epithelial hyperpermeability, dysbiosis, inflammation, visceral hypersensitivity, epigenetics and genetics, and altered brain–gut interactions. IBS considerably affects quality of life and imposes a profound burden on patients, physicians and the health-care system. The past decade has seen remarkable progress in our understanding of functional bowel disorders such as IBS that will be summarized in this Primer.

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Section: Mechanisms/pathophysiologymentioning

confidence: 99%

Irritable bowel syndrome

Enck¹,

Aziz

Barbara

et al. 2016

Nat Rev Dis Primers

784

774

View full text Add to dashboard Cite

show abstract

“…However, evidence of a potential causal role for the GI microbiota is supported by a fecal transplantation experiment in which visceral hypersensitivity, presumed to underpin abdominal pain in a subgroup of IBS patients, could be transferred via the microbiota of IBS patients to previously germ-free rats ( 86 ). Furthermore, germ-free mice colonized with the microbiota from IBS-D patients have been shown to exhibit a faster GI transit and impaired intestinal permeability as compared with mice gavaged with the microbiota from healthy humans ( 87 ). The mechanisms through which the microbiota exerts these effects are not fully understood, but the fact that supernatants from colon biopsies of IBS patients, with increased levels of histamine and proteases, excite human submucosal neurons could indicate a brain–gut axis connection ( 88 ).…”

Section: Microbiota Alterations In Ibsmentioning

confidence: 99%

Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?

Rajilić‐Stojanović

Jonkers

Salonen

et al. 2015

American Journal of Gastroenterology

304

230

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Irritable bowel syndrome (IBS) is a heterogeneous functional disorder with a multifactorial etiology that involves the interplay of both host and environmental factors. Among environmental factors relevant for IBS etiology, the diet stands out given that the majority of IBS patients report their symptoms to be triggered by meals or specifi c foods. The diet provides substrates for microbial fermentation, and, as the composition of the intestinal microbiota is disturbed in IBS patients, the link between diet, microbiota composition, and microbial fermentation products might have an essential role in IBS etiology. In this review, we summarize current evidence regarding the impact of diet and the intestinal microbiota on IBS symptoms, as well as the reported interactions between diet and the microbiota composition. On the basis of the existing data, we suggest pathways (mechanisms) by which diet components, via the microbial fermentation, could trigger IBS symptoms. Finally, this review provides recommendations for future studies that would enable elucidation of the role of diet and microbiota and how these factors may be (inter)related in the pathophysiology of IBS.

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“…This is supported by experimental evidence that germ-free (GF) animals given microbiota transplants from IBS patients show visceral hypersensitivity and GI dysmotility. 131,132 On the other hand, although stress events in early life are closely associated with IBS development, the gut microbiota profile may be possibly modified by such events. 133,134 Moreover, antibiotic-induced dysbiosis (especially in childhood) has also been shown to be involved in the development of IBS.…”

mentioning

confidence: 99%

Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders

Fukui

Miwa

2018

J Neurogastroenterol Motil

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Gut microbiota exert a pivotal influence on various functions including gastrointestinal (GI) motility, metabolism, nutrition, immunity, and the neuroendocrine system in the host. These effects are mediated by not only short-chain fatty acids produced by microbiota but also gut hormones and inflammatory signaling by enteroendocrine and immune cells under the influence of the microbiota. GI motility is orchestrated by the enteric nervous system and hormonal networks, and disturbance of GI motility plays an important role in the pathophysiology of functional gastrointestinal disorders (FGIDs). In this context, microbiota-associated mediators are considered to act on specific receptors, thus affecting the enteric nervous system and, subsequently, GI motility. Thus, the pathophysiology of FGIDs is based on alterations of the gut microbiota/gut hormone axis, which have crucial effects on GI motility.

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Tu1797 The Adoptive Transfer of Anxiety and Gut Dysfunction From IBS Patients to Axenic Mice Through Microbiota Transplantation

Cited by 9 publications

References 0 publications

Irritable bowel syndrome

Irritable bowel syndrome

Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?

Role of Gut Microbiota-Gut Hormone Axis in the Pathophysiology of Functional Gastrointestinal Disorders

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