Tualang Honey Hydrogel in the Treatment of Split-Skin Graft Donor Sites

Imran, Farrah‐Hani; Dorai, Aravazhi Ananda; Halim, Ahmad Sukari; Sulaiman, Wan Azman Wan

doi:10.3896/ibra.4.03.1.06

Cited by 12 publications

(9 citation statements)

References 15 publications

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“…The honey hydrogel group showed better healing rates at days 10 and 15. [67] In chronic wounds, a total of five clinical trials have been conducted using honey. Two trials were conducted for chronic leg ulcers.…”

Section: Non-burn Acute Woundsmentioning

confidence: 99%

Wound care with traditional, complementary and alternative medicine

Dorai

2012

Indian J Plast Surg

123

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Wound care is constantly evolving with the advances in medicine. Search for the ideal dressing material still continues as wound care professionals are faced with several challenges. Due to the emergence of multi-resistant organisms and a decrease in newer antibiotics, wound care professionals have revisited the ancient healing methods by using traditional and alternative medicine in wound management. People's perception towards traditional medicine has also changed and is very encouraging. The concept of moist wound healing has been well accepted and traditional medicine has also incorporated this method to fasten the healing process. Several studies using herbal and traditional medicine from different continents have been documented in wound care management. Honey has been used extensively in wound care practice with excellent results. Recent scientific evidences and clinical trials conducted using traditional and alternative medicine in wound therapy holds good promise in the future.

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Section: Non-burn Acute Woundsmentioning

confidence: 99%

Wound care with traditional, complementary and alternative medicine

Dorai

2012

Indian J Plast Surg

123

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“…Multiple studies across a variety of disciplines have reported on the uses of tualang honey [21,26-27], and more particularly on its use as a treatment for a variety of eye diseases [26,28]. Tan et al observed its antibacterial effects against Pseudomonas aeruginosa isolates at concentrations of ≥25% [19], while Cernak et al found that its antimicrobial properties could be used to prevent corneal scarring caused by infections [28].…”

Section: Discussionmentioning

confidence: 99%

“…It also has anti-inflammatory and antioxidant properties that can facilitate wound healing [15, 19-20]. Patients have also reported that they prefer the tualang honey hydrogel dressings to conventional dressings because the treatment has a soothing effect, reduces discomfort during dressing changes, and provides a long-lasting pleasant odor [21].…”

Section: Introductionmentioning

confidence: 99%

Clinical and Antibacterial Effects of Tualang Honey on Pseudomonas-induced Keratitis in Rabbit Eyes

Punitan

Sulaiman

Hasan

et al. 2019

Cureus

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Introduction Pseudomonas aeruginosa is a common cause of microbial keratitis that can cause a significant loss of visual acuity. Antibiotics, including fluoroquinolones and aminoglycosides, are clinically effective against Pseudomonas-induced keratitis, but their effectiveness has been conspicuously reduced as resistant pathogens have become more potent. This study sought to evaluate the clinical and antibacterial effects of tualang honey as an alternative therapeutic agent against Pseudomonas-induced keratitis. Methods We conducted a randomized control trial in which 30 rabbits were injected intrastromally with 1,000 colony-forming units (CFU) of Pseudomonas aeruginosa in the right eye of each rabbit (n = 30). The rabbits were then randomized into three groups of 10 rabbits each. Group A was treated with topical gentamicin 0.3%, group B was treated with topical tualang honey 30%, and group C received both treatments. The specified treatments were administered every two hours from 24 to 48 hours post injection, and subsequently every four hours for six days. Clinical examinations were performed on days one, two, three, five, and seven, and the mean results of slit lamp examinations (SLEs) were documented. On day seven after pseudomonas induction, the rabbits were euthanized and their corneas were harvested to determine the median CFU per cornea. Results There were no statistically significant differences (p > 0.05) in mean SLE scores (p = 0.209) or median CFU values (p = 0.820) between the three groups. Conclusion Topical gentamicin, topical tualang honey, and the combination of the two all showed similar clinical and antimicrobial effects in treating Pseudomonas-induced keratitis in rabbits. These findings should be verified in further studies with larger sample sizes and the addition of a control group.

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“…Tualang honey has been shown to possess anti-inflammatory effects. It improves wound healing by abating the oedema, inflammation, and exudation that commonly occur in all types of wounds by stimulating growth of epithelial cells and fibroblasts [ 72 , 73 , 74 ]. Tualang honey also decreases the wound size of burns and provides enhanced control and containment of burn infections, especially by bacteria such as Pseudomonas aeruginosa [ 75 ].…”

Section: Possible Mechanisms Of Tualang Honey In Learning and Memomentioning

confidence: 99%

Potential Role of Honey in Learning and Memory

et al. 2015

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The composition and physicochemical properties of honey are variable depending on its floral source and often named according to the geographical location. The potential medicinal benefits of Tualang honey, a multifloral jungle honey found in Malaysia, have recently been attracting attention because of its reported beneficial effects in various diseases. This paper reviews the effects of honey, particularly Tualang honey, on learning and memory. Information regarding the effects of Tualang honey on learning and memory in human as well as animal models is gleaned to hypothesize its underlying mechanisms. These studies show that Tualang honey improves morphology of memory-related brain areas, reduces brain oxidative stress, increases brain-derived neurotrophic factor (BDNF) and acetylcholine (ACh) concentrations, and reduces acetylcholinesterase (AChE) in the brain homogenates. Its anti-inflammatory roles in reducing inflammatory trigger and microglial activation have yet to be investigated. It is hypothesized that the improvement in learning and memory following Tualang honey supplementation is due to the significant improvement in brain morphology and enhancement of brain cholinergic system secondary to reduction in brain oxidative damage and/or upregulation of BDNF concentration. Further studies are imperative to elucidate the molecular mechanism of actions.

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Tualang Honey Hydrogel in the Treatment of Split-Skin Graft Donor Sites

Cited by 12 publications

References 15 publications

Wound care with traditional, complementary and alternative medicine

Wound care with traditional, complementary and alternative medicine

Clinical and Antibacterial Effects of Tualang Honey on Pseudomonas-induced Keratitis in Rabbit Eyes

Potential Role of Honey in Learning and Memory

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