Tubal factor infertility is associated with antibodies against Chlamydia trachomatis heat shock protein 60 (HSP60) but not human HSP60

Hjelholt, Astrid; Christiansen, Gunna; Johannesson, Thomas Gravesen; Ingerslev, Hans Jakob; Birkelund, Svend

doi:10.1093/humrep/der167

Cited by 45 publications

(39 citation statements)

References 32 publications

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“…Several studies have suggested that autoimmunity to human hsp60 is a result of cross-reactivity after a chlamydial infection (108,109). However, a study conducted by Hjelholt and colleagues did not find a correlation between tubal infertility and antibodies specific for human hsp60 in C. trachomatis infections, even though the patients produced antibodies against MOMP and chlamydial hsp60 (110).…”

Section: B Cells and Antibodiesmentioning

confidence: 97%

Genital Chlamydia trachomatis: Understanding the Roles of Innate and Adaptive Immunity in Vaccine Research

Vasilevsky¹,

Greub

Nardelli-Haefliger

et al. 2014

Clin Microbiol Rev

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SUMMARY Chlamydia trachomatis is the leading cause of bacterial sexually transmitted disease worldwide, and despite significant advances in chlamydial research, a prophylactic vaccine has yet to be developed. This Gram-negative obligate intracellular bacterium, which often causes asymptomatic infection, may cause pelvic inflammatory disease (PID), ectopic pregnancies, scarring of the fallopian tubes, miscarriage, and infertility when left untreated. In the genital tract, Chlamydia trachomatis infects primarily epithelial cells and requires Th1 immunity for optimal clearance. This review first focuses on the immune cells important in a chlamydial infection. Second, we summarize the research and challenges associated with developing a chlamydial vaccine that elicits a protective Th1-mediated immune response without inducing adverse immunopathologies.

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Section: B Cells and Antibodiesmentioning

confidence: 97%

Genital Chlamydia trachomatis: Understanding the Roles of Innate and Adaptive Immunity in Vaccine Research

Vasilevsky¹,

Greub

Nardelli-Haefliger

et al. 2014

Clin Microbiol Rev

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“…This has largely resulted from a body of literature demonstrating high-titer human antibody responses to cHSP60 in patients with tubal pathology and additionally that, in several animal models, tissue pathology developed after repeated inoculations with cHSP60 protein (reviewed in reference 138). However, this mechanism is a subject of considerable controversy because of inconsistencies between the different published findings, i.e., problems with protein preparations that involved a hypersensitive detergent being used in some animal models and cross-reactivity or poor specificity of some of the antibody tests (141)(142)(143)(144)(145)(146)(147). On the other hand, there is no doubt that cHSP60 is a predominant chlamydial antigen that does frequently elicit an immune response.…”

Section: Chsp60-induced Delayed Hypersensitivitymentioning

confidence: 99%

Human and Pathogen Factors Associated with Chlamydia trachomatis-Related Infertility in Women

et al. 2015

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SUMMARY Chlamydia trachomatis is the most common bacterial sexually transmitted pathogen worldwide. Infection can result in serious reproductive pathologies, including pelvic inflammatory disease, ectopic pregnancy, and infertility, in women. However, the processes that result in these reproductive pathologies have not been well defined. Here we review the evidence for the human disease burden of these chlamydial reproductive pathologies. We then review human-based evidence that links Chlamydia with reproductive pathologies in women. We present data supporting the idea that host, immunological, epidemiological, and pathogen factors may all contribute to the development of infertility. Specifically, we review the existing evidence that host and pathogen genotypes, host hormone status, age of sexual debut, sexual behavior, coinfections, and repeat infections are all likely to be contributory factors in development of infertility. Pathogen factors such as infectious burden, treatment failure, and tissue tropisms or ascension capacity are also potential contributory factors. We present four possible processes of pathology development and how these processes are supported by the published data. We highlight the limitations of the evidence and propose future studies that could improve our understanding of how chlamydial infertility in women occurs and possible future interventions to reduce this disease burden.

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“…Infertility attributed to C. trachomatis infection is a significant cause of morbidity, and the development of immune-mediated TFI has been associated with antibody responses to specific antigens, such as heat shock protein 60 (HSP60) and major outer membrane protein (MOMP) (31). In this study, we asked if antigen-specific CD4 ϩ or CD8 ϩ T cell responses might also be associated with TFI.…”

Section: Or 24 For Cd8mentioning

confidence: 99%

Resolution of Chlamydia trachomatis Infection Is Associated with a Distinct T Cell Response Profile

Picard

Bodmer

Gierahn

et al. 2015

Clin Vaccine Immunol

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dChlamydia trachomatis is the causative agent of the most frequently reported bacterial sexually transmitted infection, the total burden of which is underestimated due to the asymptomatic nature of the infection. Untreated C. trachomatis infections can cause significant morbidities, including pelvic inflammatory disease and tubal factor infertility (TFI). The human immune response against C. trachomatis, an obligate intracellular bacterium, is poorly characterized but is thought to rely on cell-mediated immunity, with CD4؉ and CD8 ؉ T cells implicated in protection. In this report, we present immune profiling data of subjects enrolled in a multicenter study of C. trachomatis genital infection. CD4؉ and CD8 ؉ T cells from subjects grouped into diseasespecific cohorts were screened using a C. trachomatis proteomic library to identify the antigen specificities of recall T cell responses after natural exposure by measuring interferon gamma (IFN-␥) levels. We identified specific T cell responses associated with the resolution of infection, including unique antigens identified in subjects who spontaneously cleared infection and different antigens associated with C. trachomatis-related sequelae, such as TFI. These data suggest that novel and unique C. trachomatis T cell antigens identified in individuals with effective immune responses can be considered as targets for vaccine development, and by excluding antigens associated with deleterious sequelae, immune-mediated pathologies may be circumvented.

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Tubal factor infertility is associated with antibodies against Chlamydia trachomatis heat shock protein 60 (HSP60) but not human HSP60

Cited by 45 publications

References 32 publications

Genital Chlamydia trachomatis: Understanding the Roles of Innate and Adaptive Immunity in Vaccine Research

Genital Chlamydia trachomatis: Understanding the Roles of Innate and Adaptive Immunity in Vaccine Research

Human and Pathogen Factors Associated with Chlamydia trachomatis-Related Infertility in Women

Resolution of Chlamydia trachomatis Infection Is Associated with a Distinct T Cell Response Profile

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