Tubal ligation and salpingectomy and the risk of epithelial ovarian cancer and borderline ovarian tumors: a nationwide case–control study

Abstract

We confirmed that tubal ligation reduces the risk of epithelial ovarian cancer and particularly endometrioid cancer. To our knowledge, this is the first observational publication to report on salpingectomy and ovarian cancer risk and our promising findings warrant further investigation.

The role of reproductive hormones in epithelial ovarian carcinogenesis

“…In the event of retrograde menstrual flow, those molecular alterations may facilitate endometrial tissue implantation on the surfaces of ovaries and/or peritoneum, thereby enabling tissue invasion and ultimately the manifestation of cancer (Jarboe et al 2008, Bulun 2009). This correlates well with clinical observations and molecular studies that endometrioid and clear cell cancers develop from endometriotic implants in the ovaries and/or pelvis (Veras et al 2009), as well as epidemiologic data that ligation, as opposed to surgical resection, of the FTs is protective primarily against these two subtypes of ovarian cancer (Rosenblatt & Thomas 1996, Madsen et al 2015.…”

Letter to the Editor regarding the paper by Sang-Hee Yoon et al., Bilateral salpingectomy can reduce the risk of ovarian cancer in the general population: A meta-analysis

“…Furthermore, the Begg and Mazumbar rank correlation test, the Egger's test and the failsafe N test have low statistical power to detect asymmetry for the same reason [6]. Fourth, the results of this meta-analysis were based mainly on the Madsen et al study [7] owing to its huge number of ovarian cancer cases.…”

Why have ovarian cancer mortality rates declined? Part III. Prospects for the future

“…Recently, two studies have been published which evaluate ovarian cancer risk after salpingectomy in the general population. In a population-based case-control study from Denmark, bilateral salpingectomy reduced the risk of ovarian cancer by 42%, and tubal ligation reduced the risk of ovarian cancer by 12% (the risk of endometrioid carcinomas was reduced by 34% and the risk of serous carcinomas was reduced by 8%) [25]. In a population-based cohort study from Sweden, bilateral salpingectomy reduced the risk of ovarian cancer by 65%, whereas bilateral salpingo-oophorectomy reduced the risk of ovarian cancer by 94% [26].…”