Tubal ligation in relation to menopausal symptoms and breast cancer risk

Nichols, Hazel B.; Baird, Donna D.; DeRoo, Lisa A.; Kissling, Grace E.; Sandler, Dale P.

doi:10.1038/bjc.2013.433

Cited by 16 publications

(13 citation statements)

References 17 publications

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“…Reports of the relationship between tubal ligation and breast cancer risk have been varied, including suggestions of either a reduced ( Kreiger et al , 1999 ; Calle et al , 2001 ) or increased risk ( Irwin et al , 1988 ), although the majority of studies reported no significant association ( Brinton et al , 2000 ; Eliassen et al , 2006 ; Iversen et al , 2007 ; Dorjgochoo et al , 2009 ; Press et al , 2011 ; Gaudet et al , 2013 ; Nichols et al , 2013 ), consistent with our findings.…”

Section: Discussionsupporting

confidence: 86%

Tubal ligation and incidence of 26 site-specific cancers in the Million Women Study

et al. 2016

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Background:Tubal ligation is known to be associated with a reduction in ovarian cancer risk. Associations with breast, endometrial and cervical cancers have been suggested. We investigated associations for 26 site-specific cancers in a large UK cohort.Methods:Study participants completed a questionnaire on reproductive and lifestyle factors in 1996–2001, and were followed for cancer and death via national registries. Using Cox regression models, we estimated adjusted relative risks (RRs) for 26 site-specific cancers among women with vs without tubal ligation.Results:In 1 278 783 women without previous cancer, 167 430 incident cancers accrued during 13.8 years' follow-up. Significantly reduced risks were found in women with tubal ligation for cancers of the ovary (RR=0.80, 95% CI: 0.76–0.85; P<0.001; n=8035), peritoneum (RR=0.81, 0.66–0.98; P=0.03; n=730), and fallopian tube (RR=0.60, 0.37–0.96; P=0.04; n=168). No significant associations were found for endometrial, breast, or cervical cancers.Conclusions:The reduced risks of ovarian, peritoneal and fallopian tube cancers are consistent with hypotheses of a common origin for many tumours at these sites, and with the suggestion that tubal ligation blocks cells, carcinogens or other agents from reaching the ovary, fallopian tubes and peritoneal cavity.

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Section: Discussionsupporting

confidence: 86%

Tubal ligation and incidence of 26 site-specific cancers in the Million Women Study

et al. 2016

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“…13 Cevrioglu AS et al 14 also found no difference in uterine or ovarian artery blood flow rates or ovarian hormone secretion in comparison with baseline values. 14 Finally when comparing age of menopause, Nichols HB et al 15 found no significant association between tubal ligation and menopausal age, 15 which is compatible with our findings. In our results, there is a lack of data regarding smoking status and presence of endometrioma knowing that these two factors are important for the occurring age of menopause.…”

Section: Discussionsupporting

confidence: 89%

Tubal ligation and early menopause: a case-control study

Tayeh¹,

Naba²,

Habib³

et al. 2018

OGIJ

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Submit Manuscript | http://medcraveonline.com Abbreviations: BMI, body mass index; FSH, follicle stimulating hormone; HDF, hôtel-dieu de france BackgroundThe effect of the use of tubal sterilization as a birth control method on ovarian function, ovarian reserve and menopausal age is questionable. In fact, bilateral salpingectomy or tubal ligation 1 and conservative abdominal hysterectomy 2 were sometimes related to decrease ovarian function and premature menopause. The decrease of hormonal secretion will cause endocrine disorders manifested by decreased libido, vaginal dryness, mood swings and vasomotor symptoms. The alteration of the ovarian function by sterilization has been hypothesized to be responsible for menstrual abnormalities and hormonal disturbances that characterize the so-called posttubal ligation syndrome.3,4 The logic behind this theory is that the vascularization of the ovaries by either ovarian artery or the uteroovarian anastomoses as well as the fallopian tube destruction reduce the utero-ovarian arterial blood flow in the mesosalpinx, which leads to ovarian tissue damage. 4 In 1987, Riedel HH et al. 5 found that the levels of estrogen and progesterone decrease after fallopian tube sterilization and hysterectomy.5 Nonetheless, Kusche M et al. 6 in 1994 contradicted this finding by stating that no endocrinological parameters in the perimenopause were found, neither did cycle anomalies and ovarian deficiency symptoms in terms of climacteric complaints occur earlier, nor did early onset of menopause occur more often in the operated group. In this context, the objective of the present study was to compare age at menopause between the women having already undergone tubal ligation and the control group having intact fallopian tubes. Also, we review literature about the long-term safety of tubal ligation. Methods Study settings and populationFor the purpose of this case-control study, we retrospectively reviewed the medical records of all women (cases) who had previously undergone bilateral tubal ligation between 1970 and 2010 at the department of Obstetrics and Gynecology, Hôtel-Dieu de France (HDF) University Hospital, Beirut, Lebanon.More than 200 patients were contacted of whom many were found to have changed their phone numbers. Eligible cases had to be menopaused; menopause was defined as having amenorrhea for more than 12 months with or without symptoms related to hormonal depletion. Exclusion criteria were patients who were operated for bilateral ovariectomy or salpingectomy or hysterectomy before their physiological menopause, and patients who got chemotherapy, radiation therapy or any hormonal therapy that could influence their reproductive function and alter their normal evolution towards menopause.The 50 cases were then compared to 50 randomly chosen menopaused women (controls) from the department of Obstetrics and Gynecology at HDF, who did not get any tubal ligation or gynecological surgeries (intact tubes, ovaries and uterus) but meeting the same eligibility criteria as the cases....

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“…Reports of the relationship between tubal ligation and breast cancer risk have been varied, including suggestions of either a reduced Calle et al, 2001) or increased risk (Irwin et al, 1988), although the majority of studies reported no significant association Eliassen et al, 2006;Iversen et al, 2007;Dorjgochoo et al, 2009;Press et al, 2011;Gaudet et al, 2013;Nichols et al, 2013), consistent with our findings.…”

Section: Discussionsupporting

confidence: 88%