The bone tuberculosis is triggered by the spread of Mycobacterium tuberculosis by hematogenous, the local development of the disease is the cancellous bone of the vertebral bodies, the infection spreads to neighboring levels through the anterior and posterior longitudinal ligaments postural changes consist of modifications alignment body, producing an excessive muscular tension, which often appear by compensation, to prevent or treat such changes, the use of techniques such as isostretching and McKenzie that prepares and protects the muscles of the column and limbs in order to avoid adaptation to compensate for a painful picture may influence the functional independence, quality of life and pain. Objectives: to present the clinical case of a patient affected by tuberculosis in the lumbar spine treated in physiotherapy by Isostretching and McKenzie methods in order to improve motor function, pain and health profile. Case Description: a female patient, 44 years referred to the Department of Physical Therapy at the Hospital of the Federal University of Sergipe, with clinical diagnosis of lumbar tuberculosis by means of MRI shows bone destruction of L4-L5 vertebral plateaus and purified protein derivative (PPD) 25 mm, suggestive of tuberculosis, weight loss, daily fever for 2 months, pain in the hip area and ilium character constant, paraparesis with preservation of sensitivity and functional changes. Ten physical therapy visits were carried out using the isostretching and McKenzie methods, once a week as measured by the Functional Independence Measure (FIM), Visual Analogue Scale (VAS), Nottingham Health Profile (NHP). The FIM ranged from 18 to 105, VAS 10 to 3 and NHP 100 to 34. Results: after conservative treatment the patient had decreased pain symptoms, greater functional dependence and improved quality of life.