Tuberculosis: A Global Health Problem

Zaman, Khalequ

doi:10.3329/jhpn.v28i2.4879

Cited by 224 publications

(184 citation statements)

References 17 publications

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“…Tuberculosis is one of main diseases causing mortality in developing countries 22 . The multi drug resistance of M. tuberculosis strains are the most important cause for tuberculosis, there is an urgent need for discovery of new drug to fight against it with low cost availability and minimal side effects 23 .…”

Section: Resultsmentioning

confidence: 99%

Anti-Tubercular Activity of Oxystelma Esculantum

Srikanth¹,

Prasadarao²,

Badrinath³

et al. 2017

Int. Res. J. Pharm.

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Oxystelma esculentum is one of the traditional medicinal plant which have been using in treatment of different diseases with less scientific evidence belongs to the family Ascelepiadaceae. In this point of view, the present work carried out to evaluate its anti-tuberculosis, which is the most mortality causing diseases around the world. The qualitative phytochemical analysis was carried out by standard protocols and anti-tuberculosis activity was carried out using Microplate Alamar Blue Assay method on Mycobacterium tuberculosis reference strain H37Rv. The ethanolic extract of O. esculentum flowers showed the positive results for the sterols, phenols, alkaloids, flavonoids, glycosides, tannins and carbohydrates and gave negative result for terpenoids, saponins and oils. The MIC of the extracts which showed inhibitory effect on M. tuberculosis H37Rv was determined at various concentrations of 1, 6.125, 12.5, 25, 50, 100 mg/ml. Accordingly, the MIC of Ethanolic and Aqueous extract O. esculentum in ethanol and water of were 1 mg/ml and 1 mg/ml respectively. So, the present study supports its medicinal u se and further studies on isolation of particular bioactive compounds from O. esculentum are useful.

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Section: Resultsmentioning

confidence: 99%

Anti-Tubercular Activity of Oxystelma Esculantum

Srikanth¹,

Prasadarao²,

Badrinath³

et al. 2017

Int. Res. J. Pharm.

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“…2,3 Overall one third of world's population is infected with the tuberculosis bacilli. 4 Extrapulmonary pulmonary tuberculosis can affect any organ of body.…”

Section: Discussionmentioning

confidence: 99%

Primary rectal tuberculosis mimicking malignancy

2017

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Primary rectal involvement by tuberculosis infection is rare. We present a relatively uncommon case of primary rectal tuberculosis. A 35-year-old male patient presented with history of long duration of anorexia, altered bowel habits, painful defecation, fever, and rectal bleeding. On clinical and radiological finding case was suspected of rectal malignancy. The proctoscopic biopsy was performed. On histopathology, it was diagnosed as rectal tuberculosis. We are presenting this case for its rarity, mimicking malignancy and difficulty in diagnosis.

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“…PTB patients in Bangladesh had already been reported to have high recurrence and death rates, which reinforced need for early survey, diagnosis, treatment and outcome assessment. Though, the study had given a scenario on the PTB prevalence in Bangladesh, regional and geographical impact could be assessed by long term countrywide investigation 23 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Multi-Drug Resistant (MDR) pulmonary tuberculosis in a tertiary care hospital of Narshingdi, Bangladesh

Afroz

Ali²,

Fakruddin

et al. 2013

Int J of Biomed & Adv Res

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Tuberculosis is a chronic, communicable, granulomatous disease. Most infections in humans result in an asymptomatic, latent infection and about one in ten latent infections eventually progresses to active disease, which, if left untreated, kills more than 50% of those infected. In 2011, an anti-tuberculosis (TB) drug resistance survey in Narshingdi, Bangladesh, enrolled new and retreatment patients. In the study, a number of villages were randomly selected and 264 pulmonary tuberculosis (PTB) patients were identified. All the patients received treatment with standardized first-line drug (FLD) regimens and were investigated to document treatment efficiency. Among the patients, 130 were reported in lower income, 117 in medium income and only 17 in higher income group. Farmers (95%) in low income group, and female housewives (68%) in medium income group were mostly infected. Silicosis and malnutrition were assumed responsible for high PTB cases in farmers and housewives respectively. Males were more prone to PTB and the ratios of male to female patients were found to increase with increasing age. The working youth group (25-34) and older people (above 64) were found most vulnerable. Multi-drug resistant (MDR) TB was detected in both new and retreatment patients. Patients with MDR-TB who had been declared cured with first-line anti-TB treatment had a high rate of TB recurrence and death. The rate of TB recurrence and death was high four years after MDR-TB patients were judged to have been cured. PTB patients in Bangladesh had high recurrence and death rates even after treatment with standardized FLD regimens, reinforcing the need for early survey, diagnosis and treatment, including assessment of treatment outcomes.

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Tuberculosis: A Global Health Problem

Cited by 224 publications

References 17 publications

Anti-Tubercular Activity of Oxystelma Esculantum

Anti-Tubercular Activity of Oxystelma Esculantum

Primary rectal tuberculosis mimicking malignancy

Prevalence of Multi-Drug Resistant (MDR) pulmonary tuberculosis in a tertiary care hospital of Narshingdi, Bangladesh

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