Tuberculosis and associated risk factors among children and adolescent population in Serbia: 12 year’s retrospective study

Stošić, Maja; Sagić, Lidija; Simić, Danijela; Jovanović, Verica; Rakic, Violeta; Vukicevic, Tatjana Adzić

doi:10.3855/jidc.14451

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…In addition, 40% of all children with EPRTB were diagnosed with a severe condition at the time of hospitalization in an Anti-TB hospital, and in three cases, the specific process was lethal. This indicates the need to focus the attention of health professionals on the clinical peculiarities of TB among children, which will improve the diagnosing and speed up the start of treatment [12].…”

Section: Discussionmentioning

confidence: 99%

“…Although pulmonary TB (PTB) is the most common localization of a specific process, extrapulmonary generalized lesions account for a quarter of the total number of cases [8,9] among which resistant forms are found [10,11]. Diagnosing of TB in children is difficult and time consuming, and the presence of non-specific symptoms which are distinctive to other common diseases lead to late diagnosing [12] and untimely and incorrect treatment.…”

Section: Introductionmentioning

confidence: 99%

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Peculiarities of the detection and course of the pediatric extrapulmonary tuberculosis taking into account drug resistance

Piskur

Pylypiv

Shvets

et al. 2022

Current Issues in Pharmacy and Medical Sciences

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Pediatric tuberculosis is a health problem of special significance because it is a marker for current transmission of tuberculosis in society. The research aimed at analyzing the peculiarities of detection and course of pediatric extrapulmonary tuberculosis (EPTB) taking into account the profile of drug resistance. A retrospective study of medical charts of children with EPTB (n = 47; 1st group) and pulmonary tuberculosis (PTB) (n = 49; 2nd group) aged 0-15 for 2013-2020 has been conducted. 2 subgroups with EPTB were identified separately: resistant (EPRTB) (n = 23) and sensitive (EPSTB) (n = 24). Results and discussion. The frequency of EPTB was 9.8%. Tuberculosis of peripheral LN (40.5%), CNS (27.7%), bones and joints (23.4%) was significantly more often diagnosed, than other lesions. Almost half of children with EPTB had a miliary distribution. In 44.7% of children with EPTB contact with a patient with tuberculosis was not established. EPRTB was significantly more common among children under 1 and up to 3 years of age than EPSTB. The resistance to combination of HR (73.6%) was found more often than to HRES (10.5%), HRS, H and Z (5.3% each; p<0.01). In 73.9% of children with EPRTB was detected when seeking medical care, in 13.0% the time to diagnosing lasted 6 months. Among children with EPRTB, gradual course was more frequent and in 47.8% intoxication syndrome was dominating. 78.3% of children with EPRTB were not vaccinated. Conclusion. The above indicates the need to intensify preventive measures against tuberculosis among children, especially at risk groups, make monitoring of contacts and their treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Peculiarities of the detection and course of the pediatric extrapulmonary tuberculosis taking into account drug resistance

Piskur

Pylypiv

Shvets

et al. 2022

Current Issues in Pharmacy and Medical Sciences

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show abstract

“…([SHUWV HVWLPDWH WKDW WKH LQFUHDVH LQ FKHPRdrug-resistant TB (CDR-TB) will be 300,000 new cases annually [16]. The simulation of the FRQVHTXHQFHV RI WKH &29,' SDQGHPLF IRU Ukraine [2] ,Q WKH \HDU UHWURVSHFWLYH VWXG\ 0% 6WRVLF et al [14]…”

mentioning

confidence: 99%

The profile of drug resistance of Mycobacterium tuberculosis and clinical features of extrapulmonary resistant tuberculosis among children living in Lviv region, Ukraine

Piskur¹,

Pylypiv²,

Shvets³

et al. 2022

MPU

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Pediatric tuberculosis (TB) is a serious infectious disease that affects many children worldwide and is more likely to be extrapulmonary than adult TB. The purpose - to analyze the profile of drug resistance of Mycobacterium tuberculosis and clinical features of extrapulmonary resistant (EPR) TB among children from Lviv region, Ukraine. Materials and methods. We analyzed all cases of EPR TB (n=23) and extrapulmonary sensitive (EPS) TB (n=24) among 478 medical charts of children, who were hospitalized in the Lviv Anti-TB hospital during 2013-2020. Results. It was found out that EPR TB was diagnosed significantly more often at the age of 1 year and up to 3 years old than EPS TB and significantly less often - among children aged 4-7 years. The children with EPR TB were significantly more likely to live in rural areas and they were significantly more likely to be from families with less than 2 children, compared to EPS TB. The children with EPR TB were more often diagnosed with meningeal and central nervous system (CNS) TB, less often - with TB of the bones and joints, only they had TB of the intestine, compared to EPS TB. Miliary pulmonary TB and the predominance of bilateral process were more common at EPR TB. Among children with EPR TB, rifampicin-resistant TB was significantly more common found than the risk of multidrug-resistant TB (MDR-TB) and monoresistant TB. The resistance profile of MDR-TB showed that 17.4% are resistant to the combination of HR (H-isoniazid, R-rifampicin), 8.6% - to HRES (E-ethambutol, S-streptomycin), 4.3% - to НRS. Among 43.5% of children with EPR TB the contact with a TB patient was not established. At the same time, only a third of children who had came into contact with bacterial exсretors were under dispensary observation and only about 9% received chemoprophylaxis. Conclusions. In order to prevent the development of EPR TB, it is necessary to improve TB prevention measures among the most vulnerable segments of the population. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.

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Pediatric Tuberculosis Characteristic in West Nusa Tenggara Regional General Hospital During COVID-19 Pandemic 2019-2021

Indrasuari,

Indriyani

2024

AJP

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Tuberculosis (TB) infection is still an important health problem worldwide, especially in children. The Coronavirus Disease (COVID-19) pandemic has affected the priority of healthcare including TB services. Many health services reported a significant decrease in TB detection, notification, treatment and prevention due to COVID-19 policies. Therefore, we conducted a study to determine the characteristics of pediatric TB patients in West Nusa Tenggara Province General Hospital during COVID-19 pandemic. This study was a retrospective study using registry data from the Pediatric Respirology Division, Department of Child Health, West Nusa Tenggara Province General Hospital from March 2019 to December 2021. Of 225 children with TB disease, there were 66.2% outpatient and 33.8% inpatient. Thirty point seven percents (69/225) were in ages group 5 to 11 years old and mostly were males (69.8%). West Lombok Regency was the district with highest number of subjects (37.3%). Majority of subjects were visited in March-December 2019, nearly before pandemic. Polymerase Chain Reaction (PCR) test for TB were performed in 172 (76.5%) subjects and showed positive result in 22/172 (9.8%). Most of them were pulmonary TB (72.9%) and 9.8% bacteriologically confirmed. Only 4 (1.8%) of children were died. Pulmonary TB is the most common TB disease among pediatric TB patients in this study. During study period, the number of hospital visit was decreased due to COVID-19 policies. This findings can guided healthcare providers to improve detection, treatment and prevention of TB disease post COVID-19 pandemic.

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Tuberculosis and associated risk factors among children and adolescent population in Serbia: 12 year’s retrospective study

Cited by 4 publications

References 20 publications

Peculiarities of the detection and course of the pediatric extrapulmonary tuberculosis taking into account drug resistance

Peculiarities of the detection and course of the pediatric extrapulmonary tuberculosis taking into account drug resistance

The profile of drug resistance of Mycobacterium tuberculosis and clinical features of extrapulmonary resistant tuberculosis among children living in Lviv region, Ukraine

Pediatric Tuberculosis Characteristic in West Nusa Tenggara Regional General Hospital During COVID-19 Pandemic 2019-2021

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